Participation After Multidisciplinary Rehabilitation for Moderate to Severe Traumatic Brain Injury in Adults: A Systematic Review

Brasure, Michelle; Lamberty, Greg J.; Sayer, Nina A.; Nelson, Nathaniel W.; MacDonald, Roderick; Ouellette, Jeannine; Wilt, Timothy J

doi:10.1016/j.apmr.2012.12.019

Cited by 77 publications

(68 citation statements)

References 32 publications

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“…Despite the potential value of longer-term and multidisciplinary rehabilitation in helping to maximize physical, cognitive and psychological outcomes following ABI, evidence relating to treatment outcome and efficacy is limited in quantity [6][7][8][9][10]. This is partly due to the complexity of conducting research with a heterogeneous population encompassing different neurological conditions (i.e.…”

Section: Introductionmentioning

confidence: 95%

Functional outcomes of community-based brain injury rehabilitation clients

et al. 2014

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Section: Introductionmentioning

confidence: 95%

Functional outcomes of community-based brain injury rehabilitation clients

et al. 2014

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“…Severe TBI patients are mostly subjected to surgery (acute treatment) to remove or repair ruptured blood vessels and bruised brain tissue, as well as other complications due to brain trauma, or prescribed with medications to mitigate symptoms such as headaches, chronic pain, behavioral problems, depression, and seizures (13,120,121). A majority of TBI patients are relegated to rehabilitation therapy (14,33,59,117), although obviously this type of intervention does not prevent or reverse much of the brain damage resulting from the injury. Indeed, there is a substantial need for clinically efficacious therapies for TBI, especially those that prevent and/or reduce secondary injury and facilitate long-term functional recovery after TBI.…”

Section: Traumatic Brain Injury (Tbi)mentioning

confidence: 99%

G-CSF as an Adjunctive Therapy with Umbilical Cord Blood Cell Transplantation for Traumatic Brain Injury

et al. 2015

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Traumatic brain injury (TBI), a major contributor to deaths and permanent disability worldwide, has been recently described as a progressive cell death process rather than an acute event. TBI pathophysiology is complicated and can be distinguished by the initial primary injury and the subsequent secondary injury that ensues days after the trauma. Therapeutic opportunities for TBI remain very limited with patients subjected to surgery or rehabilitation therapy. The efficacy of stem cell-based interventions, as well as neuroprotective agents in other neurological disorders of which pathologies overlap with TBI, indicates their potential as alternative TBI treatments. Furthermore, their therapeutic limitations may be augmented when combination therapy is pursued instead of using a single agent. Indeed, we demonstrated remarkable combined efficacy of human umbilical cord blood (hUCB) cell therapy and granulocyte-colony-stimulating factor (G-CSF) treatment in TBI models, providing essential evidence for the translation of this approach to treat TBI. Further studies are warranted to determine the mechanisms underlying therapeutic benefits exerted by hUCB + G-CSF in order to enhance its safety and efficacy in the clinic.

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“…For example, a recent review by Krasny-Pacini, Chevignard, and Evans (2014) found that the effectiveness of goal management training in people with ABI was greater when it was combined with other interventions such as personal homework and daily life training activities rather than with paper-and-pencil, office-type tasks. Furthermore, the EvidenceBased Review of Moderate to Severe Acquired Brain Injury project (Brasure et al, 2012) concluded that transitional living settings during the last weeks of inpatient rehabilitation are associated with greater independence than inpatient rehabilitation alone. In another review, which discussed the effectiveness of remediation of language and communication deficits in people with TBI and stroke, Cicerone et al (2005) suggest that interventions provided in the home or community by trained volunteers or caretakers may be valuable adjuncts to traditional treatments, particularly for chronic aphasia.…”

Section: Discussionmentioning

confidence: 99%

“…For an overview of these studies see the reviews of Turner-Stokes, Pick, Nair, Disler, andWade, 2015, andBrasure et al, 2012. However, to our knowledge, there are no studies that have focused on the possible additional gains of a combined programme that treats people with ABI alternately in a clinical and in a home setting.…”

Section: Introductionmentioning

confidence: 99%

Outcomes of a community-based treatment programme for people with acquired brain injury in the chronic phase: a pilot study

Spanje¹,

Smeets

Haastregt

et al. 2017

Neuropsychological Rehabilitation

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The objective of the study was to evaluate the outcomes of Brainz, a low intensity community-based treatment programme for people with acquired brain injury (ABI). Participants were 62 people with sustained ABI (5.2 years post-injury, SD = 4.5) and 35 family caregivers. Participants attended two to five cognitive and physical group modules and received two hours of individual home treatment every two weeks. Primary outcomes for people with ABI were participation, perceived difficulties in daily life and need of care, level of goal attainment, and self-esteem. Primary family caregiver outcome was perceived burden of care. Attrition rate of people with ABI was 24% (n = 15), and of family caregivers was 31% (n = 11). People with ABI were more satisfied with the level of their participation after completing Brainz (p < .01), but showed no change in participation frequency or in restrictions (both ps > .01). They perceived fewer difficulties in daily life and less need of care (both ps < .01). Also, in two cognitive modules people improved on their goal achievement (p < .01). However, their self-esteem was reduced (p < .01). Caregiver burden was reduced (p < .01). This study has provided preliminary evidence of the effectiveness of a combined group-based clinical and individual home-based treatment programme, but more research is needed, preferably in larger controlled studies.

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Participation After Multidisciplinary Rehabilitation for Moderate to Severe Traumatic Brain Injury in Adults: A Systematic Review

Cited by 77 publications

References 32 publications

Functional outcomes of community-based brain injury rehabilitation clients

Functional outcomes of community-based brain injury rehabilitation clients

G-CSF as an Adjunctive Therapy with Umbilical Cord Blood Cell Transplantation for Traumatic Brain Injury

Outcomes of a community-based treatment programme for people with acquired brain injury in the chronic phase: a pilot study

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