Partially Reversible Osteopenia After Surgery for Primary Hyperparathyroidism

Martin, Philippe; Bergmann, Pierre; Gillet, C.; Fuss, Michel; Kinnaert, Paul; Corvilain, Jacques; Geertruyden, Jean Van

doi:10.1001/archinte.1986.00360160103014

Cited by 74 publications

(25 citation statements)

References 10 publications

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“…6,[20][21][22][23] Further documentation of cortical bone loss was obtained by analysis of biopsy specimens of iliac crest bone in which several studies, including our own, have shown that cortices are thinner (Figures 29.2 and 29.3) 50,53-55 or excessively porous in PHPT. 52,55 A catabolic effect of excessive PTH secretion on cortical bone was also suggested by van Doorn et al 52 who observed a positive correlation between circulating intact PTH and cortical porosity.…”

Section: Cortical Bonementioning

confidence: 99%

“…[13][14][15][16][17][18] The introduction of bone densitometry helped to focus attention on the extent and sites of bone loss in mild, asymptomatic PHPT, especially with regard to the involvement of the two major skeletal compartments, cortical and cancellous bone. [19][20][21][22][23][24] Application of the technique of bone histomorphometry to the percutaneous bone biopsy has also provided much new insight into the effects of mild PHPT on the skeleton. Furthermore, the biopsy sample can be used to investigate the material properties of both the mineral and organic components of the bone matrix.…”

Section: Introductionmentioning

confidence: 99%

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Bone Histomorphometry and Bone Quality in Primary Hyperparathyroidism

et al. 2015

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Section: Cortical Bonementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bone Histomorphometry and Bone Quality in Primary Hyperparathyroidism

et al. 2015

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“…Regardless of the type of parathyroidectomy done, almost all patients return to normal biochemical values after surgery [37]. In addition, parathyroidectomy has been shown to halt the end-organ effect of hyperparathyroidism (HPT), resulting in bone mineral density (BMD) increases and cessation of progressive renal dysfunction [37][38][39][40][41][42].…”

Section: Metabolic Changesmentioning

confidence: 99%

Asymptomatic primary hyperparathyroidism: a surgical perspective

Mack¹,

Pasieka²

2004

Surgical Clinics of North America

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“…Controversy stems from disparate results, in particular those regarding the site and degree of bone loss [3][4][5][6][7][8][9]. However, most densitometric and histomorphometric results seem to favor the hypothesis that in the mild form of PHPT there is a preservation of cancellous bone mass [8][9][10][11] as well as architecture [12][13][14][15][16][17][18][19], due to the anabolic effect at the axial skeleton.…”

Section: Introductionmentioning

confidence: 99%

Uneven Deficits in Vertebral Bone Density in Postmenopausal Patients with Primary Hyperparathyroidism as Evaluated by Posterior–Anterior and Lateral Dual-Energy Absorptiometry

Minisola

Rosso²,

Romagnoli

et al. 2002

Osteoporos Int

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This investigation was undertaken to determine whether the preservation of bone mass in patients with mild primary hyperparathyroidism (PHPT) could be detected when measuring spine density in the lateral projection. We compared the bone mineral density (BMD) of L2-L4 utilizing the posterior-anterior (PA) and lateral projections in postmenopausal patients with PHPT and in a group of 27 postmenopausal normal women. Thirty-three consecutive postmenopausal patients with PHPT were studied; 25 were asymptomatic whereas the remaining 8 suffered complications related to the disease. Based upon the criteria established by the Consensus Conference on the Management of Asymptomatic PHPT, only 10 of the 25 asymptomatic patients could be considered affected by mild disease; the remaining patients were classified as having moderate disease. Patients with mild disease had mean lateral total BMD values (0.682 +/- 0.113 g/cm(2)) significantly higher than normal women (0.588 +/- 0.076, p<0.02) and patients with moderate disease (0.599 +/- 0.077, p<0.05). There were significant differences among the three groups in both PA L2-L4 and L1-L4 levels: patients with mild disease had significantly higher mean BMD values than patients with moderate disease and normal women, when either three or four vertebrae were considered. Interestingly, at this latter site, patients with moderate disease had significantly ( p<0.05) lower values than normal women. Our results indicate that patients with mild PHPT have a preservation of vertebral mass when compared with the other hyperparathyroid patients and normal women, when taking into account both the mainly trabecular portion and the whole vertebra. The finding that when the PA projection was assessed, BMD values of patients with moderate disease were significantly lower than those of normal women, might be attributed to the detrimental effect of raised parathyroid hormone levels on the cortical component of the vertebral body.

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Partially Reversible Osteopenia After Surgery for Primary Hyperparathyroidism

Cited by 74 publications

References 10 publications

Bone Histomorphometry and Bone Quality in Primary Hyperparathyroidism

Bone Histomorphometry and Bone Quality in Primary Hyperparathyroidism

Asymptomatic primary hyperparathyroidism: a surgical perspective

Uneven Deficits in Vertebral Bone Density in Postmenopausal Patients with Primary Hyperparathyroidism as Evaluated by Posterior–Anterior and Lateral Dual-Energy Absorptiometry

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