Partially photodegradable hybrid hydrogels with elasticity tunable by light irradiation

Yanagawa, Fumiki; Mizutani, Takeomi; Sugiura, Shinji; Takagi, Toshiyuki; Sumaru, Kimio; Kanamori, Toshiyuki

doi:10.1016/j.colsurfb.2014.11.020

Cited by 11 publications

(12 citation statements)

References 32 publications

(40 reference statements)

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“…Dynamic hydrogels exhibit either a softening (Caliari et al, 2016b;Frey and Wang, 2009;Kloxin et al, 2010;Yanagawa et al, 2015) or stiffening (Caliari et al, 2016a;Guvendiren and Burdick, 2012;Liu et al, 2017) behavior, whereby the elasticity of the hydrogel either decreases or increases upon triggering. Photoresponsive hydrogels are of special interest due to the possibility of combining them with spatial patterning methods (e.g.…”

Section: Dynamic Substrates and Mechanical Memorymentioning

confidence: 99%

“…Stiffness differences can be readily accomplished using photolithographic techniques and photodegradable hydrogels, or photo initiator-mediated crosslinking. Here, the hydrogel is irradiated with UV light through a mask presenting a pattern of opacity, thereby achieving differential exposure of the hydrogel (Kidoaki and Matsuda, 2008;Nemir et al, 2010;Yanagawa et al, 2015). This approach can achieve stiffness patterns with micrometre precision.…”

Section: Introductionmentioning

confidence: 99%

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Engineering the cellular mechanical microenvironment – from bulk mechanics to the nanoscale

Matellan

Hernández

2019

Journal of Cell Science

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The field of mechanobiology studies how mechanical properties of the extracellular matrix (ECM), such as stiffness, and other mechanical stimuli regulate cell behaviour. Recent advancements in the field and the development of novel biomaterials and nanofabrication techniques have enabled researchers to recapitulate the mechanical properties of the microenvironment with an increasing degree of complexity on more biologically relevant dimensions and time scales. In this Review, we discuss different strategies to engineer substrates that mimic the mechanical properties of the ECM and outline how these substrates have been applied to gain further insight into the biomechanical interaction between the cell and its microenvironment.

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Section: Dynamic Substrates and Mechanical Memorymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Engineering the cellular mechanical microenvironment – from bulk mechanics to the nanoscale

Matellan

Hernández

2019

Journal of Cell Science

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“…Hydrogels are synthesized from hydrophilic polymers with a three‐dimensional network connected by functional crosslinkers that are capable of preserving large amounts of water without dissolving . One of the recent trends in hydrogel research has been a focus on stimuli‐responsive hydrogels, which have the capacity to change their shape and volumes reversibly in response to triggers such as temperature, pH, ion concentrations, and light, thereby displaying great potential for various biomedical and pharmaceutical applications. Among these, pH‐sensitive hydrogels have been intensely investigated for drug delivery applications, because pH is a pivotal environmental parameter in biomedical systems and is simple to control both in vitro and in vivo …”

Section: Introductionmentioning

confidence: 99%

Preparation of a Salecan/poly(2‐acrylamido‐2‐methylpropanosulfonic acid‐co‐[2‐(methacryloxy)ethyl]trimethylammonium chloride) Semi‐IPN Hydrogel for Drug Delivery

Wei

et al. 2017

ChemMedChem

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Salecan is a water-soluble bacterial polysaccharide consisting of glucopyranosyl units linked by α-1,3 and β-1,3 glycosidic bonds. salecan is suitable for the development of hydrogels for biomedical applications, given its outstanding physicochemical and biological profiles. In this study we designed a new semi-interpenetrating polymer network hydrogel that introduces the salecan polysaccharide into a stimuli-responsive poly(2-acrylamido-2-methylpropanosulfonic acid-co-[2-(methacryloxy)ethyl]trimethylammonium chloride) (PAM) hydrogel matrix for controlled insulin release. We found that salecan not only tunes the structure and pore size of the PAM hydrogels, but also endows them with adjustable water release rates. More importantly, in vitro drug loading/release assays demonstrated that insulin is efficiently loaded into the resulting hydrogels and can be released in an on-demand manner by controlling the pH and salecan dose. Furthermore, cell viability and cell adhesion experiments verified the cell compatibility of these hydrogel carriers. Together, these results make salecan-incorporated PAM hydrogels promising materials for drug delivery.

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“…Sakai et al developed a high‐strength poly(ethylene glycol) (PEG) hydrogel with homogeneous network structures by utilizing the NHS‐amino reaction. Yanagawa et al prepared photodegradable hybrid hydrogels with tunable elasticity via mixing NHS‐PC‐4‐arm‐PEG, and NHS‐4‐arm‐PEG with amino‐4‐arm‐PEG. The NHS‐amino reaction was the crosslinking mode in the formation of hydrogels and the photocleavage behavior of o ‐nitrobenzyl moiety was utilized to cause photodegradability in hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Injectable dual redox responsive diselenide‐containing poly(ethylene glycol) hydrogel

Gong

Meng

et al. 2017

J Biomedical Materials Res

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An injectable dual redox responsive diselenide-containing poly(ethylene glycol) (PEG) hydrogel was successfully developed by combining the conceptions of injectable hydrogels and dual redox responsive diselenides. In the first step, four-armed PEG was modified with N-hydroxysuccinimide (NHS)-activated esters and thereafter, crosslinked by selenocystamine crosslinkers to form injectable hydrogels via the rapid reaction between NHS-activated esters and amino groups. The cross-sectional morphology, mechanical properties, and crosslinking modes of hydrogels were well characterized via scanning electron microscope (SEM), rheological measurements, and Fourier transform infrared spectra, respectively. In addition, the oxidation- and reduction-responsive degradation behaviors of hydrogels were observed and analyzed. The model drug, rhodamine B, was encapsulated in the hydrogel. The drug-loaded hydrogel exhibited a dual redox responsive release profile, which was consistent with the degradation experiments. The results of all experiments indicated that the formulated injectable dual redox responsive diselenide-containing PEG hydrogel can have potential applications in various biomedical fields such as drug delivery and stimuli-responsive drug release. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2451-2460, 2017.

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Partially photodegradable hybrid hydrogels with elasticity tunable by light irradiation

Cited by 11 publications

References 32 publications

Engineering the cellular mechanical microenvironment – from bulk mechanics to the nanoscale

Engineering the cellular mechanical microenvironment – from bulk mechanics to the nanoscale

Preparation of a Salecan/poly(2‐acrylamido‐2‐methylpropanosulfonic acid‐co‐[2‐(methacryloxy)ethyl]trimethylammonium chloride) Semi‐IPN Hydrogel for Drug Delivery

Injectable dual redox responsive diselenide‐containing poly(ethylene glycol) hydrogel

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