Partial solubility parameters of piroxicam and niflumic acid

Solubility Prediction of Drugs in Mixed Solvents Using Partial Solubility Parameters

“…On the basis of the preliminary analysis, niflumic acid solubility data sets in ethanol + water mixtures31 at various temperatures behave as outliers. To confirm this, the solubilities data of niflumic acid in water (0.0000012 expressed as mole fraction solubility)57 and ethanol (0.0145)58 at 25°C were collected and the values were used to predict the solubility of niflumic acid in ethanol + water mixtures at 25°C. The obtained MPD was 76.7%, whereas the MPD using originally reported values in ethanol and water was 215%.…”

Screening of Binary Solvent Mixtures and Solvate Formation of Indomethacin

“…The solubility parameter is divided into three terms describing the dispersive (d d ), polar (d p ), and hydrogen bonding (d h ) interactions. The partial solubility parameters for drug compounds can be determined experimentally or calculated using group contribution methods [17]. Estimation of the solubility of component 1 in solvent 2 is typically based on the solubility parameter distance R a , which can be calculated using Eq.…”

IUPAC-NIST Solubility Data Series. 102. Solubility of Nonsteroidal Anti-inflammatory Drugs (NSAIDs) in Neat Organic Solvents and Organic Solvent Mixtures

“…181,182 There have been several publications 64,171,[183][184][185] involving the solubility of piroxicam in organic solvents. Most notably, Bustamante et al 171 measured the mole fraction solubility of piroxicam in 22 different organic solvents, including two saturated hydrocarbons (heptane and cyclohexane), one aromatic hydrocarbon (benzene), one alkyl alkanoate (ethyl ethanoate), one dialkyl ether (1,1′-oxybisethane) and one cyclic ether (1,4-dioxane), two chloroalkanes (trichloromethane and 1,2-dichloroethane) and one chlorinated aromatic hydrocarbon (chlorobenzene), seven alcohols (methanol, ethanol, 1-pentanol, 1-octanol, 1,2-ethanediol, 1,2-propanediol, and 1,2,3-propanetriol), one alkanone (propanone) and one aromatic ketone (acetophenone), and four miscellaneous organic solvents (ethanoic acid, propanoic acid, formamide, and N,Ndimethylformamide) at 298 K and atmospheric pressure. Wyttenbach et al 185 investigated the solubility of piroxicam in ethanol, polyethylene glycol 400, and olive oil at ambient room temperature using a residual solid screening assay method performed in 96-well multiscreen solubility filter plates.…”