Solubility Prediction of Drugs in Mixed Solvents Using Partial Solubility Parameters

Jouyban, Abolghasem; Shayanfar, Ali; Panahi‐Azar, Vahid; Soleymani, Jafar; Yousefi, Behrooz H.; Acree, William E.; York, Peter

doi:10.1002/jps.22589

Cited by 53 publications

(37 citation statements)

References 48 publications

(22 reference statements)

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“…16,17,23 Experimental solubility and density data were fitted to the Jouyban−Acree model, and the constants were computed. The results showed that the overall MPD value of back-calculated solubility of binary mixtures was 4.1 %.…”

Section: Discussionmentioning

confidence: 99%

Lamotrigine Solubility in Some Nonaqueous Solvent Mixtures at 298.2 K

Farjami

Jouyban

2015

J. Chem. Eng. Data

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Experimental solubility of lamotrigine in binary mixtures of methanol + acetone, ethanol + acetone, 1-propanol + acetone, ethyl acetate + acetone, ethyl acetate + methanol, ethyl acetate + ethanol, ethyl acetate + 1-propanol at 298.2 K are reported. The measured data were fitted to the Jouyban−Acree model and the overall mean percentage deviation (MPD) of back-calculated solubilities was 4.0 %. Also, densities of the saturated solutions were measured and fitted to the Jouyban−Acree model. The overall MPD value for this analysis was 6.0 %.

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Section: Discussionmentioning

confidence: 99%

Lamotrigine Solubility in Some Nonaqueous Solvent Mixtures at 298.2 K

Farjami

Jouyban

2015

J. Chem. Eng. Data

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“…(2) is applicable to the solubility prediction of drugs in other PEGs + water mixtures at various temperatures [10]. Recently, a general model which is a combination of the Jouyban-Acree model and partial solubility parameters was proposed for prediction solubility of drugs in cosolvent + water mixture as [11]:…”

Section: Methodsmentioning

confidence: 99%

“…(3) were computed using a commercial software package [18]. The partial solubility parameters of PEG 200 are ı d1 = 13.67 MPa 1/2 , ı p1 = 11.66 MPa 1/2 , and ı h1 = 16.77 MPa 1/2 and those of water are ı d2 = 13.56 MPa 1/2 , ı p2 = 18.41 MPa 1/2 , and ı h2 = 20.45 MPa 1/2 [11]. In the density analysis, the experimental densities of the solute free PEG 200 + water mixtures at various temperatures were fitted to the adopted version of the Jouyban-Acree model [19].…”

Section: Methodsmentioning

confidence: 99%

Thermodynamic studies of fluphenazine decanoate solubility in PEG 200+water mixtures

Panahi‐Azar

Ahmadian

Martínez

et al. 2012

Fluid Phase Equilibria

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“…Because both temperature and ethanol concentration might vary with time, knowledge of the solubility curves of both polyphenols as a function of those two variables is essential. Using experimental data already available in the literature, the Jouyban–Acree model was used in order to have an explicit solubility function:

\begin{matrix} T \cdot \ln (x_{i}) & = A_{0} + A_{1} T + A_{2} T x_{italicEtOH} + A_{3} x_{italicEtOH} + A_{4} x_{italicEtOH}^{2} \\ + A_{5} x_{italicEtOH}^{3} + A_{6} x_{italicEtOH}^{4} \end{matrix}

…”

Section: Methodsmentioning

confidence: 99%

Preferential crystallization for the purification of similar hydrophobic polyphenols

Silva

Vieira

Ottens

2018

J of Chemical Tech & Biotech

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BACKGROUNDPreferential crystallization is a common technique used in the purification of enantiomers, proving that crystallization may also be applied to the purification of very similar molecules by seeding the solution with the desired compound. Nonetheless, its application to other organic molecules is less widely documented in the literature. Knowing that chemically related polyphenols are generally co‐produced by fermentation and their purification can be too expensive for their market value, this technique may contribute to developing a downstream process with less expensive steps. The goal of this work is to show the applicability of the preferential crystallization concept to the purification of similar polyphenols – naringenin and trans‐resveratrol – with either single or coupled crystallizers.RESULTSAfter developing the required crystallization kinetic models, an experiment using two coupled vessels was devised, where a 63% yield of naringenin and 44% yield of trans‐resveratrol was obtained, with ≥98% purity in both cases. When the vessels were working independently, 81% of pure trans‐resveratrol (started 60% pure) and 70% of pure naringenin (started 68% pure) were recovered.CONCLUSIONThe experiments performed show the possibility of separately purifying two similar molecules (from 60% to roughly 100%) with promising yields, despite their similar solubility. This method, which can be significantly improved, might provide an economically attractive way for the production of low added value products. © 2017 The Authors. Journal of Chemical Technology & Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

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Solubility Prediction of Drugs in Mixed Solvents Using Partial Solubility Parameters

Cited by 53 publications

References 48 publications

Lamotrigine Solubility in Some Nonaqueous Solvent Mixtures at 298.2 K

Lamotrigine Solubility in Some Nonaqueous Solvent Mixtures at 298.2 K

Thermodynamic studies of fluphenazine decanoate solubility in PEG 200+water mixtures

Preferential crystallization for the purification of similar hydrophobic polyphenols

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