Partial Prostatectomy Using Nd:YAG Laser for Management of Canine Prostate Carcinoma

L’Eplattenier, Henry; Nimwegen, S.A. van; Sluijs, F.J. van; Kirpensteijn, Jolle

doi:10.1111/j.1532-950x.2006.00165.x

Cited by 47 publications

(46 citation statements)

References 23 publications

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“…All animals underwent a surgical procedure as described previously [32]. The technique involved a subcapsular partial prostatectomy, sparing the urethra and the dorsal aspect of the prostate capsule including the neurovascular structures essential to the normal function of the urethral sphincter.…”

Section: Surgical Techniquementioning

confidence: 99%

RETRACTED ARTICLE: Diagnostic investigations of canine prostatitis incidence together with benign prostate hyperplasia, prostate malignancies, and biochemical recurrence in high-risk prostate cancer as a model for human study

et al. 2014

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The aim of this study was to evaluate the prevalence of acute and chronic inflammation, benign prostatic hyperplasia (BPH), and cancer of the prostate glands in the canine as a human model in prostate disorders. The study was carried out on 12 cases of different male dogs of terrier (50%), German shepherd (25%) breeds, and Greden (25%), and the age of the dogs ranged from 6 to 13 years (average age 7.8 ± 3.6). The bodyweight ranged from 3.6 to 7.9 kg. Signalment, clinical signs, and diagnostic tools such as ultrasonography, urinary cytology, and histopathology are presented. Dysuria was the most common clinical sign in this study and occurred in 10/12 canine (83.3%) included. Other clinical signs included lameness (5/12 canine, 41.6%) and constipation (3/12 canine, 25%). The range of duration of clinical signs was 5 days to 7 months. Moreover, in the present study, the urinary biochemical markers of different prostate lesions include blood, protein, and glucose and were detected in 11/12 cases (91.6%), 5/12 cases (41.6%), and 2/12 cases (16.6%), respectively. Taken together, sonographic data were classified into four groups based on histological diagnosis. In 7/12 cases (58.4%), the prostate appeared to have BPH lesions, and the remaining lesions included inflammation (3/12 cases, 25%), abscess (1 case, 8.3%), and adenocarcinoma (1 case, 8/3%) on ultrasound. In all cases, prostate tissue had an irregular echotexture. None of the dogs had sonographic evidence of sublumbar lymph node enlargement. Histopathologically, we looked at the prevalence of inflammation (33.3% chronic and 8.3% acute) and BPH (58.4%) in dogs of different ages and breeds, and also, we observed chronic inflammation in >20% of dogs, which was about 25% in 3 cases of the 12 cases referred. More chronic inflammation was associated with more BPH. The majority of the asymptomatic inflammation that is detected in the prostate is classified as chronic inflammation (i.e., as evidenced by the presence of monocytic and/or lymphoplasmacytic inflammatory cell infiltrates); however, acute inflammation is also observed to a lesser degree. Acute inflammation, as is typically evidenced by the infiltration of neutrophils, is classically an indicator of an infectious process. Finally, the patients included seven castrated, four castrated together with antibiotic therapy, and one castrated together with chemotherapy intact male dogs, which were treated with the mentioned cases. In conclusion, chronic prostatic inflammation could be a central mechanism in BPH progression, but the pathological features of tissue inflammation were different between BPH and prostate cancer (PCa). Nevertheless, the histological examination of prostate biopsies remains the only way to diagnose prostatic disorders.

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Section: Surgical Techniquementioning

confidence: 99%

RETRACTED ARTICLE: Diagnostic investigations of canine prostatitis incidence together with benign prostate hyperplasia, prostate malignancies, and biochemical recurrence in high-risk prostate cancer as a model for human study

et al. 2014

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“…Survival of dogs with urogenital carcinoma has been improved by NSAIDs alone and combined with chemotherapeutic agents such as mitoxantrone and carboplatin . Survival times in dogs with prostatic malignancies vary widely, from 17 to 654 days, depending on the stage at diagnosis and treatment pursued . Furthermore, current therapeutic strategies have been associated with poor response and high complication rates.…”

Section: Introductionmentioning

confidence: 99%

“…Case selection for this procedure has been based on criteria, such as small, intracapsular primary lesions, without evidence of metastatic disease . Few reports describe the outcomes of total prostatectomy, most concluding that complication rates are too high and survival times too short to recommend this technique as routine treatment of dogs with prostatic neoplasia . The most common complication consists of urinary incontinence, diagnosed in 33%‐100% of cases …”

Section: Introductionmentioning

confidence: 99%

Total prostatectomy as a treatment for prostatic carcinoma in 25 dogs

Bennett¹,

Matz

Henderson

et al. 2018

Veterinary Surgery

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“…Other techniques of total cystectomy and urinary diversion have been suggested, but are all associated with significant postoperative complications (e.g., urinary tract infection, pyelonephritis, metabolic complications). [11][12][13][14][15] Palliative techniques such as placement of a permanent cystostomy catheter, 16 self-expanding urethral stent, 17 or surgical laser debulking via cystoscopy [18][19][20][21] to relieve urine outflow obstruction, although associated with significant morbidity, may be acceptable solutions in case of urethral obstruction. However, the presence of both urethral and ureteral obstructions precludes the use of these procedures as a sole treatment.…”

Section: Introductionmentioning

confidence: 99%

A Technique for Resection of Invasive Tumors Involving the Trigone Area of the Bladder in Dogs: Preliminary Results in Two Dogs

2008

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Objective-To describe a surgical technique for resection of the entire bladder neck, including the trigone and proximal urethra in dogs with invasive tumors causing life-threatening urinary tract obstruction. Study Design-Clinical case reports. Animals-Dogs (n ¼ 2) with bladder tumors. Methods-Circumferential excision of the bladder neck and proximal urethra with preservation of the neurovascular pedicles was performed to remove a rhabdomyosarcoma (dog 1) and a transitional cell carcinoma (dog 2) involving the trigone and bladder neck that were causing urinary tract obstruction. Reconstruction of the bladder and proximal urethra included bilateral ureteroneocystostomy. Adjuvant chemotherapy was administered postoperatively to both dogs. Results-Postoperatively, dogs 1 and 2 were continent after 7 and 17 days, respectively, and regained normal urinary function after resolution of a transient pollakiuria. Dog 1 had no evidence of local or regional recurrence; however, a large solitary pulmonary metastatic lesion was diagnosed 8 months later. The dog was euthanatized despite a lack of clinical signs. Dog 2 had at least 1 metastatic lesion in the abdominal wall 6 months later and was euthanatized at 580 days because of renal failure. Conclusion-En-bloc removal of the bladder neck and proximal urethra with preservation of the dorsal vascular and nervous pedicles, although a technically challenging procedure, can be performed without associated urinary incontinence or bladder wall necrosis. Clinical Relevance-In dogs with invasive bladder tumors causing life-threatening urinary tract obstruction, resection of the bladder neck and proximal urethra should be considered as a promising surgical alternative to urinary diversion. r

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Partial Prostatectomy Using Nd:YAG Laser for Management of Canine Prostate Carcinoma

Abstract: Subcapsular partial prostatectomy is a potential palliative treatment for PCA in dogs and may lead to the resolution of clinical signs for several months.

Cited by 47 publications

References 23 publications

RETRACTED ARTICLE: Diagnostic investigations of canine prostatitis incidence together with benign prostate hyperplasia, prostate malignancies, and biochemical recurrence in high-risk prostate cancer as a model for human study

RETRACTED ARTICLE: Diagnostic investigations of canine prostatitis incidence together with benign prostate hyperplasia, prostate malignancies, and biochemical recurrence in high-risk prostate cancer as a model for human study

Total prostatectomy as a treatment for prostatic carcinoma in 25 dogs

A Technique for Resection of Invasive Tumors Involving the Trigone Area of the Bladder in Dogs: Preliminary Results in Two Dogs

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