Partial Nephrectomy Using Renal Artery Perfusion for Cold Ischemia: Functional and Oncologic Outcomes

Beri, Avi; Lattouf, Jean‐Baptiste; Deambros, Oswald; Grüll, Martin; Gschwendtner, Manfred; Ziegerhofer, Josef; Leeb, Karl; Janetschek, Günter

doi:10.1089/end.2008.0152

Cited by 27 publications

(11 citation statements)

References 18 publications

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“…The impact of ischemia and subsequent reperfusion injury has been studied by some groups. Beri et al used a combination of creatinine clearance time, peak concentration time, and MAG 3 isotope clearance to accurately evaluate postoperative parenchymal function [17]. Another group used the duration of renal parenchymal retention of MAG 3 as a tool to assess ischemic renal damage [18].…”

Section: Discussionmentioning

confidence: 99%

Renal Function and Oncologic Outcomes after Cryoablation or Partial Nephrectomy for Tumors in Solitary Kidneys

et al. 2011

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PurposePreservation of renal function is of paramount importance in patients with tumors in solitary kidneys. We compared the renal function and oncologic outcomes of patients treated by partial nephrectomy with those of patients treated by cryoablation for solitary kidney tumors.Materials and MethodsAll patients with solitary kidneys who were treated for renal tumors at our institution between 1997 and 2007 were included in the screen. We retrospectively identified 23 patients who underwent cryoablation and 15 patients who underwent partial nephrectomy.ResultsThe two groups were similar with regard to age, gender, and tumor laterality. Patients in the partial nephrectomy group had a larger tumor size (3.4 cm vs. 2.5 cm, p=0.01), higher mean estimated blood loss (316 cc vs. 87 cc, p<0.001), longer duration of hospital stay (5.8 vs. 1.8 days, p<0.001), and a higher rate of perioperative complications (53.3% vs. 8.7% patients, p=0.03). Percentage changes in the glomerular filtration rate postoperatively and on follow-up were found to be similar in the two groups. Both the cryoablation and the partial nephrectomy groups with mean follow-ups of 31.2 months and 30.8 months, respectively, had evidence of local or distant recurrence in 3 patients each (13% and 20% respectively, p=0.7). Both groups had a similar mean overall survival (88.9 and 86.9 months in the cryoablation and partial nephrectomy groups, respectively, p=0.8).ConclusionsFor tumors in solitary kidneys, renal functional and clinical outcomes for cryoablation were not significantly different from those for partial nephrectomy. However, cryoablation has the distinct advantage of a lower morbidity rate and can be preferentially offered to selected cases.

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Section: Discussionmentioning

confidence: 99%

Renal Function and Oncologic Outcomes after Cryoablation or Partial Nephrectomy for Tumors in Solitary Kidneys

et al. 2011

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“…Included characteristics were the name of the first author, year of publication, country of study origin, source of control group, sample size, and HardyWeinberg equilibrium (Table 1). [4][5][6][7][8][9] Statistical analyses All statistical analyses were performed with software (Stata 11.0, StataCorp, College Station, TX, USA) using 2-sided tests. The chi-square test was used to compare genotype (likelihood ratio P value) and allele frequencies (continuity correction P value) between the kidney recipient and healthy control groups.…”

Section: Data Extractionmentioning

confidence: 99%

“…Hardy-Weinberg equilibrium was tested using the chi-square test for the distribution of frequencies of 14-bp polymorphism. 4 A Begg funnel plot was constructed and the degree of asymmetry of the plot was evaluated using Egger test to evaluate publication bias. Statistically significant publication bias was defined by P ≤ .05.…”

Section: Data Extractionmentioning

confidence: 99%

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2014

Exp Clin Transplant

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Objectives: The human leukocyte antigen-G may have a positive role in graft acceptance in human organ transplant. Several studies have reported an association between the human leukocyte antigen-G-14-base-pair-insertion/deletion polymorphism and risk of developing kidney graft rejection, but the results are inconclusive. We performed a metaanalysis to evaluate this association. Conclusions: There may be no association between 14-base-pair polymorphisms and risk of developing kidney allograft rejection. Additional studies with larger sample size and better study design are justified.

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“…[49]. Alternativ ist es möglich, die Niere mittels eisgekühlter Perfusionslösung zu kühlen, welche durch Kanülierung der geklemmten Arterie eingebracht wird [50]. Mancherorts wird die Nierenteilresektion standardisiert in kalter Ischämie durchgeführt.…”

Section: Laparoskopische Tumornephrektomieunclassified

Aktuelle chirurgische Aspekte des Nierenzellkarzinoms

Zigeuner

Pummer

2009

Wien Med Wochenschr

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Surgery of renal cell carcinoma (RCC) has undergone substantial changes during the past years. Until the 1990s, radical nephrectomy together with ipsilateral adrenalectomy was considered the golden standard. Meanwhile it was demonstrated that tumours up to 4 cm in diameter and a normal contralateral kidney can be treated by partial nephrectomy (elective indication) without compromising oncological safety. Development of laparoscopy influenced renal surgery significantly. Currently, laparoscopic nephrectomy is considered a golden standard for renal masses larger than 4 cm (T1b-T2), whereas open radical nephrectomy is reserved for large, locally advanced tumours, caval extension or enlarged lymph nodes. Adrenalectomy can be omitted if the adrenal appears normal. Tumours less than 4 cm should undergo partial nephrectomy. The better renal functional reserve after elective partial compared with radical nephrectomy seems to be associated with better overall survival. For partial nephrectomy the open approach currently remains the golden standard, whereas laparoscopy is reserved for specialized centres.

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Partial Nephrectomy Using Renal Artery Perfusion for Cold Ischemia: Functional and Oncologic Outcomes

Cited by 27 publications

References 18 publications

Renal Function and Oncologic Outcomes after Cryoablation or Partial Nephrectomy for Tumors in Solitary Kidneys

Renal Function and Oncologic Outcomes after Cryoablation or Partial Nephrectomy for Tumors in Solitary Kidneys

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Aktuelle chirurgische Aspekte des Nierenzellkarzinoms

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