1991
DOI: 10.1001/archderm.127.12.1846
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Partial lipodystrophy and dermatomyositis

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Cited by 20 publications
(20 citation statements)
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“…17 The clinical appearance in our patients, with loss of subcutaneous fat from the face and progressing to the trunk and upper limbs, is consistent with acquired partial lipodystrophy, but fever, skin lesions as described herein, and the other inflammatory manifestations we observed are not found in these types of lipodystrophy. We speculate that lipodystrophy may be the end result of chronic inflammation involving the fat directly, as in the extensive panniculitis seen in dermatomyositis or other 'connective tissue' panniculitides of children 18,19 ; alternatively, it may be due to increased expression of proinflammatory cytokines in adipose tissue, particularly interleukin 6 and tumor necrosis factor a, coupled with reduced secretion of adiponectin and leptin, as in HIV-associated lipodystrophy, 20,21 which shows a pattern of lipodystrophy similar to our patients.…”
Section: Discussionmentioning
confidence: 98%
“…17 The clinical appearance in our patients, with loss of subcutaneous fat from the face and progressing to the trunk and upper limbs, is consistent with acquired partial lipodystrophy, but fever, skin lesions as described herein, and the other inflammatory manifestations we observed are not found in these types of lipodystrophy. We speculate that lipodystrophy may be the end result of chronic inflammation involving the fat directly, as in the extensive panniculitis seen in dermatomyositis or other 'connective tissue' panniculitides of children 18,19 ; alternatively, it may be due to increased expression of proinflammatory cytokines in adipose tissue, particularly interleukin 6 and tumor necrosis factor a, coupled with reduced secretion of adiponectin and leptin, as in HIV-associated lipodystrophy, 20,21 which shows a pattern of lipodystrophy similar to our patients.…”
Section: Discussionmentioning
confidence: 98%
“…Twenty-seven cases of APL have been associated with autoimmune diseases 8,17,19,31,34,42,55,88,109,116,120,124,130,137,149,171,177,180 , including 7 patients from our case series (Patients 3, 4, 12, 19, 22, 25, 32) (see Tables 1 and 2). The most common associated autoimmune disease was systemic lupus erythematosus (SLE) reported in 7 patients 42,55,88,177 .…”
Section: Association With Autoimmune Diseasesmentioning
confidence: 99%
“…Several investigators have performed subcutaneous fat biopsy from the lipodystrophic areas 11,16,20,121,165,171,173,190 . In 1 report, relative adipocyte volume was 65% in the lipodystrophic areas vs nonlipodystrophic areas 16 .…”
Section: Adipose Tissue Histopathologymentioning
confidence: 99%
“…The amyloidoses represent a group of clinical disorders of diverse etiologies that have as a common pathophysiologic denominator the deposition of misfolded protein-based amyloid fibrils in the interstitial space of various organs (10). Although the features in our patient are not typical of cardiac amyloidosis, the (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). The images are captured in series, 12 min after a bolus dose of gadolinium.…”
Section: Discussionmentioning
confidence: 95%