Partial kindling and emotional bias in the cat: lasting aftereffects of partial kindling of the ventral hippocampus

Adamec, Robert E.; Stark-Adamec, Cannie

doi:10.1016/s0163-1047(83)90212-1

Cited by 51 publications

(14 citation statements)

References 15 publications

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“…This finding fits well previous studies, which have reported increased hippocampal activation in highly aggressive mice (Haller et al, 2006) and have linked aberrant hippocampal activity with heightened aggression (Adamec and Stark-Adamec, 1983; Adamec, 1991; Ibi et al, 2008; Mellanby et al, 1981). Alternatively, the strong c-fos expression in the hippocampus may not have been dependent on aggression per se, and instead may have been more related to other aspects of behavioral arousal that accompany homecage intrusion, such as investigation of novel odor of the intruder male.…”

Section: Discussionsupporting

confidence: 93%

Pattern of forebrain activation in high novelty-seeking rats following aggressive encounter

Clinton¹,

Kerman²,

Orr³

et al. 2011

Brain Research

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We have previously demonstrated that selectively-bred High (bHR) and Low (bLR) novelty-seeking rats exhibit agonistic differences, with bHRs acting in a highly aggressive manner when facing homecage intrusion. In order to discover the specific neuronal pathways responsible for bHRs’ high levels of aggression, the present study compared c-fos mRNA expression in several forebrain regions of bHR/bLR males following this experience. bHR/bLR males were housed with female rats for two weeks, and then the females were replaced with a male intruder for 10 min. bHR/bLR residents were subsequently sacrificed by rapid decapitation, and their brains were removed and processed for c-fos in situ hybridization. Intrusion elicited robust c-fos mRNA expression in both phenotypes throughout the forebrain, including the septum, amygdala, hippocampus, cingulate cortex, and the hypothalamus. However, bHRs and bLRs exhibited distinct activation patterns in select areas. Compared to bHR rats, bLRs expressed greater c-fos in the lateral septum and within multiple hypothalamic nuclei, while bHRs showed greater activation in the arcuate hypothalamic nucleus and in the hippocampus. No bHR/bLR differences in c-fos expression were detected in the amygdala, cortical regions, and striatum. We also found divergent 5-HT1A receptor mRNA expression within some of these same areas, with bLRs having greater 5-HT1A, but not 5-HT1B, receptor mRNA levels in the septum, hippocampus and cingulate cortex. These findings, together with our earlier work, suggest that bHRs exhibit altered serotonergic functioning within select circuits during an aggressive encounter.

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Section: Discussionsupporting

confidence: 93%

Pattern of forebrain activation in high novelty-seeking rats following aggressive encounter

Clinton¹,

Kerman²,

Orr³

et al. 2011

Brain Research

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“…Rosen and colleagues [36] found that FPS was exaggerated in amygdala-kindled, but not in hippocampus-kindled, rats compared to sham-kindled controls. Partial amygdala kindling also renders aggressive cats less aggressive but more defensively fearful [37]. Full kindling is anxiogenic as measured with the elevated plus maze [38,39].…”

Section: Discussionmentioning

confidence: 99%

Phenytoin normalizes exaggerated fear behavior in p-chlorophenylalanine (PCPA)-treated rats

Hughes

Keele

2006

Epilepsy & Behavior

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Temporal lobe epilepsy may be associated with emotional difficulties such as depression or anxiety. Since the amygdala is involved in both epilepsy and emotion, common neural mechanisms in this temporal lobe structure may underlie the emotional disturbances observed in people with epilepsy. The neurotransmitter serotonin (5-hydroxytryptamine, or 5-HT) is implicated in many psychopathologies, and 5-HT also modulates amygdala excitability. Therefore, the present study used the fear potentiated startle (FPS) paradigm to investigate the effect of neuronal excitability on fear behavior in rats treated with p-chlorophenylalanine (PCPA) to chronically inhibit 5-HT synthesis. PCPA treatment selectively enhanced FPS in individually-housed rats. The exaggerated FPS response was reduced to control level by the anticonvulsant phenytoin (10mg/kg) and phenytoin (30 mg/kg) further decreased FPS behavior. These data suggest that a sub-seizure state of neuronal excitability mediated by low 5-HT in brain fear circuits may be associated with pathological fear behavior.

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“…Moreover, these behaviors have been found to be unaffected by implantation of electrodes in over 40 cats (Adamec, 1978;Adamec and Stark-Adamec, 1983a). Nevertheless, in this study six cats with withdrawal from rat scores within the range of the withdrawal scores of cats given FG-7142 were tested to replicate re-test stability of behavior.…”

Section: Analyses Of Covariancementioning

confidence: 86%

Acute and lasting effects of FG-7142 on defensive and approach-attack behavior in cats—implications for models of anxiety which use response suppression

Adamec

1991

J Psychopharmacol

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The effect of the anxiogenic β-carboline, FG-7142, on defense and approach-attack behavior in the cat was investigated. FG-7142 (10 mg/kg) enhanced defensive responses to rats and mice when tested 10 and 20 min after injection. At the same time, FG-7142 suppressed approach and attack responses to prey. Behavioral effects of FG-7142 were blocked by the specific benzodiazepine receptor blocker RO-15-1788 (10 mg/kg). One or two administrations of FG-7142 were sufficient to produce a lasting (up to 105 days) enhancement of defensive response to rats but not to mice. Defensive response to conspecific threat vocalizations was also lastingly increased. Two injections of FG-7142 produced a lasting suppression of approach-attack on rats only, whereas one injection of FG-7142 did not. The lasting suppression of some measures of approach-attack was found to be independent of the fear-enhancing properties of FG-7142. Tests of the effects of RO-15-1788 on the lasting after-effects of FG-7142 revealed at least two mechanisms which mediate the lasting changes in behavior, one which is dependent upon the benzodiazepine receptor and one which is not. The implications of these findings for rodent models of anxiety which use response suppression to assess fearful 'anxiogenic' effects of drugs are discussed.

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Partial kindling and emotional bias in the cat: lasting aftereffects of partial kindling of the ventral hippocampus

Cited by 51 publications

References 15 publications

Pattern of forebrain activation in high novelty-seeking rats following aggressive encounter

Pattern of forebrain activation in high novelty-seeking rats following aggressive encounter

Phenytoin normalizes exaggerated fear behavior in p-chlorophenylalanine (PCPA)-treated rats

Acute and lasting effects of FG-7142 on defensive and approach-attack behavior in cats—implications for models of anxiety which use response suppression

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