“…We believe that the bLR rat represents a useful new rodent model of co-morbid anxiety- and depression given their naturally high levels of anxiety- and depressive-like behavior (Kabbaj et al, 2000, White et al, 2007, Flagel et al, 2010, Clinton et al, 2011a, Perez et al, 2009, Clinton et al, 2008, Stedenfeld et al, 2011, Garcia-Fuster et al, 2012), diminished aggression (Kerman et al, 2011) and sexual motivation (McCullumsmith et al, 2007), and reduced responsivity to reward (Kabbaj, 2004, Piazza et al, 1989, Flagel et al, 2011, Davis et al, 2008, Garcia-Fuster et al, 2010, Cummings et al, 2011). The present study together with our earlier work (Clinton et al, 2008, Stedenfeld et al, 2011) also demonstrates bLRs’ high vulnerability to chronic stress whereas bHRs are fairly resilient.…”