Partial duplication of the PRLR and SPEF2 genes at the late feathering locus in chicken

Elferink, Martin; Vallée, Amélie; Jungerius, Annemieke P; Crooijmans, R.P.M.A.; Groenen, Martien A. M.

doi:10.1186/1471-2164-9-391

Cited by 115 publications

(128 citation statements)

References 27 publications

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“…Strikingly, in addition to a PRLR gene localized on chromosome Z, a partially duplicated PRLR gene (designated as dPRLR gene herein) has also been identified recently (Elferink et al 2008). The dPRLR gene was found within the sex-linked late-feathering (LF) K locus on chromosome Z, within which a partial duplication of sperm flagellar 2 gene (named dSPEF2) was identified simultaneously (Elferink et al 2008).…”

Section: Introductionmentioning

confidence: 99%

“…The dPRLR gene was found within the sex-linked late-feathering (LF) K locus on chromosome Z, within which a partial duplication of sperm flagellar 2 gene (named dSPEF2) was identified simultaneously (Elferink et al 2008). It has been reported that this dominant sex-linked K allele is associated with the LF phenotype of newly hatched chicks with the retarded emergence of flight feathers, while the recessive kC allele determines the early-feathering (EF) phenotype of chicks (Serebrovsky 1922, Elferink et al 2008. The identification of the dPRLR gene within the K locus (but not within the kC locus) suggests that dPRLR is probably a candidate gene associated with LF development in chicks (Elferink et al 2008, Wang et al 2010a, Luo et al 2012.…”

Section: Introductionmentioning

confidence: 99%

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Characterization of the novel duplicated PRLR gene at the late-feathering K locus in Lohmann chickens

Huang

et al. 2013

Journal of Molecular Endocrinology

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A partial duplication of the prolactin (PRL) receptor gene (designated as dPRLR) has been identified at the late-feathering (LF) K locus on chromosome Z of some chicken strains recently, implying that dPRLR is probably a candidate gene associated with LF development in chickens. However, little is known about the structure, functionality, and spatiotemporal expression of the dPRLR gene in chickens. In this study, using 3 0 -RACE and RT-PCR, the full-length cDNA of the dPRLR obtained from the kidneys of male Lohmann layer chickens carrying a K allele was cloned. The cloned dPRLR is predicted to encode a membranespanning receptor of 683 amino acids, which is nearly identical to the original PRLR, except for its lack of a 149-amino acid C-terminal tail. Using a 5! STAT5-Luciferase reporter system and western blot analysis, we demonstrated that dPRLR expressed in HepG2 cells could be potently activated by chicken PRL and functionally coupled to the intracellular STAT5 signaling pathway, suggesting that dPRLR may function as a novel receptor for PRL. RT-PCR assays revealed that similar to the original PRLR gene, dPRLR mRNA is widely expressed in all embryonic and adult tissues examined including the skin of male Lohmann chickens with a K allele. These findings, together with the expression of PRL mRNA detected in the skin of embryos at embryonic day 20 and 1-week-old chicks, suggest that skin-expressed dPRLR and PRLR, together with plasma and skin-derived PRL, may be involved in the control of the LF development of chicks at hatching. Moreover, the wide tissue expression of dPRLR implies that dPRLR may regulate other physiological processes of chickens carrying the K allele.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Characterization of the novel duplicated PRLR gene at the late-feathering K locus in Lohmann chickens

Huang

et al. 2013

Journal of Molecular Endocrinology

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“…이들 중 우모 발생 속도에 관여하는 만우성 유 전자를 이용한 깃털 감별법(feather-sexing)이 산업적으로 가 장 널리 이용되고 있다 (Mueller and Moultrie, 1952;Plumart and Mueller, 1954;Siegel et al, 1957;Somes, 1969;Warren, 1976;McGibbon, 1977;SAFRS, 2011, Sohn et al, 2012. 깃 털 감별법은 우모 발생 속도에 관여하는 조우성(early-fea- et al, 1988;Iraqi and Smith, 1995;Bitgood, 1999;Elferink et al, 2008) (Plumart and Mueller, 1954;Somes, 1970;Dunnington and Siegel, 1986a), 일부 연구자들은 성장율과 이들 형 질간에 거의 관련이 없다고 하였다 (Hays, 1951;Godfrey and Farnsworth, 1952;Lowe et al, 1965). 또한 조우성 개체들의 산란능력 및 난중이 만우성 개체에 비해 우수하고, 초산 일 령도 빠르다고 하였으나 (Lowe et al, 1965;Harris et al, 1984), 조만성이 산란능력에 큰 영향이 없음도 보고하고 있 다 (Lowe and Garwood, 1981).…”

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Influence of Early- and Late-feathering Phenotype on Productive Performance in the Feather-sexing Strains of Korean Native Chicken

Sohn

Kim²,

Park³

et al. 2013

Korean Journal of Poultry Science

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The vent sexing and the auto-sexing by using sex-linked traits are general sexing methods of day-old chicks. Currently, the feather sexing which is based on the differences in the feather characteristics at hatching is the representative sexing method of chicken, because the late-feathering is sex-linked trait. The feather sexing can be used if the breed has dominant feathering gene (K) in maternal and recessive gene (k + ) in paternal. Therefore it is necessary to identify the association of feathering genes and quantitative traits in chickens. In this study, we investigated the influence of the rate of feathering on productive traits in Korean Native Chicken. In results, there was no significant difference between early-feathering chickens and late-feathering chickens in reproductive performance such as fertility and hatchability. Livability, body weights, egg production, egg weight and egg quality also did not significantly differ between early-and late-feathering chickens. Age at first egg was the only trait of those tested in which significant difference was observed. The early-feathering chickens laid eggs 3 days earlier than late-feathering chicken. As a result, there is no influence of feathering phenotypes on productive performance in Korean Native Chickens. Consequentially, establishing the feather sexing strain is available using the Korean Native Chicken breed without considering of the effect of feathering genes on productive traits.

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“…생존율과 깃털 조만성 간에는 밀접한 관련이 있음을 보고하고 있는데 만우성 유전 자가 ev21 유전자와 매우 가깝게 연관되어 있어 lymphoid leucosis virus에 대한 감염율을 증가시키고 따라서 폐사율을 증가 시키는 것으로 밝혀졌다 (Harris et al, 1984;Bacon et al, 1988;Fadly, 1988, 1994;Iraqi and Smith, 1995). 이와 더 불어 조만성 유전자 좌위에 대한 연구도 활발히 진행되어 조우성 유전자와 만우성 유전자의 분자유전학적 식별 방법을 개발하고 (Smith and Levin, 1991;Tixier-Boichard et al, 1994 Iraqi andSmith, 1995), 나아가 만우성 개체의 homozygous와 heterozygous의 구분도 가능함을 제시하였다 (Elferink et al, 2008 …”

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“…, 1977, SAFRS, 2011. 이러한 깃털감별법(feathersexing)은 조우성(rapid-feathering)과 만우성(slow-feathering)에 관여하는 유전자(K, k + )가 Z 염색체에 위치하기 때문에 (Bacon et al, 1988;Lakshmanan et al, 1992;Iraqi and Smith, 1995;Bitgood, 1999Elferink et al, 2008 (Spillman, 1908;Punnett, 1923;Nickerson, 1944;Bitgood, 1988;Campo, 1991;Kerje et al, 2003;Dorshorst and Ashwell, 2009;Hellstrom et al, 2010), 왜소유전자 (Hutt, 1959;Bernier and Arscott, 1960;Cole and Austic, 1980;Stewart et al, 1984;BurghelleMayeur et al, 1989;Tixier-Boichard et al, 1990;Merat et al, 1994;Vasilatos-Younken et al, 1997;Cole, 2000), 색소침 착억제유전자 (Bitgood, 1985(Bitgood, , 1988Levin et al, 1993;Zhang et al, 2000;Dorshorst and Ashwell, 2009), 만우성유전자 (Somes, 1969(Somes, , 1975Harris et al, 1984;Bacon et al, 1986Bacon et al, , 1988Smith and Nelsen, 1993;Bitgood, 1999;Fotsa et al, 2001;Hamoen et al, 2001;Khosravinia, 2009), 안구돌출유전 자 (Bitgood and Whitley, 1986;…”

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Genotype Frequencies of the Sex-Linked Feathering and Their Phenotypes in Domestic Chicken Breeds for the Establishment of Auto-Sexing Strains

Sohn¹,

Park²,

Song³

et al. 2012

Journal of Animal Science and Technology

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The method of sexing based on differences in the rate of feather growth provides a convenient and inexpensive approach. The locus of feather development gene (K) is located on the Z chromosome and can be utilized to produce phenotypes that distinguish between the sexes of chicks at hatching. To establish the auto-sexing native chicken strains, this study analyzed the genotype frequency of the feathering in domestic chicken breeds. The method of classification of slow-and rapid-feathering chickens was also investigated. In the slow-feathering chicks, the coverts were either the same length or longer than the primary wing feathers at hatching. However, the rapid-feathering chicks had the primary wing feathers that were longer than the coverts. The growth pattern of tail feather also distinctively differed between the rapid-and slow-feathering chicks after 5-days. The accuracy of wing feather sexing was about 98% compared with tail sexing. In domestic chicken breeds, Korean Black Cornish, Korean Rhode Island Red, and Korean Native Chicken-Red had both dominant (K) and recessive (k + ) feathering genes. The other breeds of chickens, Korean Brown Cornish, Ogol, White Leghorn, Korean Native Chicken-Yellow, -Gray, -White and -Black had only the recessive feathering gene (k + ). Consequently, feather sexing is available using the domestic chicken breeds. Establishing the maternal stock with dominant gene (K-) and paternal stock with recessive gene (k + k + ), the slow-feathering characteristic is passed from mothers to their sons, and the rapid-feathering characteristic is inherited by daughters from their fathers.

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Partial duplication of the PRLR and SPEF2 genes at the late feathering locus in chicken

Cited by 115 publications

References 27 publications

Characterization of the novel duplicated PRLR gene at the late-feathering K locus in Lohmann chickens

Characterization of the novel duplicated PRLR gene at the late-feathering K locus in Lohmann chickens

Influence of Early- and Late-feathering Phenotype on Productive Performance in the Feather-sexing Strains of Korean Native Chicken

Genotype Frequencies of the Sex-Linked Feathering and Their Phenotypes in Domestic Chicken Breeds for the Establishment of Auto-Sexing Strains

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