Partial conduction blocks in <i>N</i>‐hexane neuropathy

Pastore, Carlos Alberto; Izura, Virginia; Marhuenda, D.; Prieto, M.J.; Roel, J; Cardona, Antonio

doi:10.1002/mus.10183

Cited by 32 publications

(14 citation statements)

References 14 publications

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“…Conduction blocks were seen. On needle electromyography (EMG), the features of denervation have been seen in all the patients in a previous study [6,[14][15][16]. Also in our patient there were features suggestive of sensorymotor neuropathy with a conduction block in bilateral common peroneal nerves and absence of conduction in bilateral sural nerves.…”

Section: Vertigo and Cold Allodynia In N-hexane Neuropathy C A S E R supporting

confidence: 75%

N-hexane neuropathy with vertigo and cold allodynia in a silk screen printer: A case study

Pradhan

Tandon

2015

Int J Occup Med Environ Health

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N-hexane neuropathy is an occupational disease caused by exposure to n-hexane, which is used as a solvent in silk screen printing. Here, we describe a 35-year-old man, a silk screen printer by profession, who presented with dizziness, distal swelling of both lower limbs for 10 months and tingling and burning sensation in both feet for 9.5 months along with cold allodynia. The patient had normal results of a motor and sensory system examination, apart from an impaired temperature sense. Nerve conduction tests showed a conduction block in bilateral common peroneal nerves and absence of conduction in bilateral sural nerves. These symptoms resolved when further exposure to n-hexane was ceased but cold allodynia remained. Thus, cold allodynia and impaired temperature sense can be a manifestation of n-hexane neuropathy. Hence, abnormalities on nerve conduction studies can be detected in n-hexane neuropathy patients, even before clinical examination detects any such abnormalities. In the case of the patients presenting with sensory motor neuropathy, history of occupational exposure to n-hexane becomes important, as the sooner the disease is detected, the better the chances of recovery.

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Section: Vertigo and Cold Allodynia In N-hexane Neuropathy C A S E R supporting

confidence: 75%

N-hexane neuropathy with vertigo and cold allodynia in a silk screen printer: A case study

Pradhan

Tandon

2015

Int J Occup Med Environ Health

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“…Exposure may occur with the use of degreasing solvents and cleansers, and after intentional inhalation of household glues for intoxication [16,17]. Chronic exposure may result in a distal sensory motor neuropathy, whereas acute exposure may lead to predominantly motor and cranial nerve features.…”

Section: Environmental Toxinsmentioning

confidence: 99%

“…Chronic exposure may result in a distal sensory motor neuropathy, whereas acute exposure may lead to predominantly motor and cranial nerve features. Focal conduction block may be present on neurophysiologic assessment [16]. Giant axonal swellings consisting of neurofi lamentous aggregates are the classic neuropathologic fi nding in N-hexane neuropathy [15•].…”

Section: Environmental Toxinsmentioning

confidence: 99%

Not all neuropathy in diabetes is of diabetic etiology: Differential diagnosis of diabetic neuropathy

Freeman

2009

Curr Diab Rep

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Diabetic peripheral neuropathy is the most common peripheral neuropathy in the developed world; however, not all patients with diabetes and peripheral nerve disease have a peripheral neuropathy caused by diabetes. Several (although not all) studies have drawn attention to the presence of other potential causes of a neuropathy in individuals with diabetes; 10% to 50% of individuals with diabetes may have an additional potential cause of a peripheral neuropathy and some may have more than one cause. Neurotoxic medications, alcohol abuse, vitamin B(12) deficiency, renal disease, chronic inflammatory demyelinating neuropathy, inherited neuropathy, and vasculitis are the most common additional potential causes of a peripheral neuropathy in these series. The most common disorders in the differential diagnosis of a generalized diabetic peripheral neuropathy are discussed in this article. Prospective studies to investigate the prevalence of other disorders that might be responsible for a peripheral neuropathy in individuals with diabetes are warranted.

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“…1,2 Development of hexacarbon neuropathy as a result of nhexane exposure was first recognized and reported in the 1960s. 2 N-hexane is a petroleum product used in solvents and glues and is associated with occupational neuropathies seen in automobile mechanics, 2 shoe-makers, 3,4 purse makers 5 and furniture finishers. 4 Toxicological studies of n-hexane have shown that this solvent causes peripheral neuropathy in both experimental animals and humans.…”

Section: Introductionmentioning

confidence: 99%

Peripheral neuropathy and visual evoked potential changes in workers exposed to n-hexane

Kutlu

Gömceli

Sönmez

et al. 2009

Journal of Clinical Neuroscience

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Partial conduction blocks in N‐hexane neuropathy

Cited by 32 publications

References 14 publications

N-hexane neuropathy with vertigo and cold allodynia in a silk screen printer: A case study

N-hexane neuropathy with vertigo and cold allodynia in a silk screen printer: A case study

Not all neuropathy in diabetes is of diabetic etiology: Differential diagnosis of diabetic neuropathy

Peripheral neuropathy and visual evoked potential changes in workers exposed to n-hexane

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