Parthenium the terminator: An update

Lakshmi, Chembolli; Srinivas, CR

doi:10.4103/2229-5178.96698

Cited by 20 publications

(15 citation statements)

References 56 publications

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“…1 Splinter hemorrhages on multiple nails without any obvious trauma are indicative of systemic causes: not only IE, but antiphospholipid syndrome, vasculitis, and treatment with systemic tyrosine kinase inhibitors or hemodialysis. 2 However, to our knowledge, Janeway lesions or splinter hemorrhages due to noninfective endomyocarditis, such as eosinophilic endomyocarditis, have not been reported.…”

Section: Janeway Lesions and Splinter Hemorrhages In A Patient With Ementioning

confidence: 81%

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Parthenium Dermatitis With Deck-Chair Sign

2015

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Section: Janeway Lesions and Splinter Hemorrhages In A Patient With Ementioning

confidence: 81%

“…Other patterns include chronic actinic dermatitislike, seborrheic dermatitis, prurigo nodularislike, photosensitive lichenoid eruption, and hands-and-feet dermatitis patterns. 2 Repeated exacerbations are common due to con-…”

Section: Parthenium Dermatitis With Deck-chair Signmentioning

confidence: 99%

Parthenium Dermatitis With Deck-Chair Sign

2015

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“…This noxious weed is also commonly known as carrot grass, congress grass, famine weed, star weed, Santa-maria and is responsible for the loss of crop productivity and various harmful human health issues such as hay fever, asthma, bronchitis, and contact dermatitis. 3,4 Partheniummediated allergies can be due to direct or indirect contact. 5 The allergens of P. hysterophorus are sesquiterpene lactones present in stem, leaves, flowers and pollens, and majorly concentrated in the trichomes of the plant.…”

Section: Introductionmentioning

confidence: 99%

Parthenium hysterophorus mediated inflammation and hyper‐responsiveness via NF‐κB pathway in human A549 lung cancer cell line

Kaur

Gupta

Thakur

et al. 2020

Environmental Toxicology

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Being one of the notorious weed P. hysterophorus has invaded almost every part India and is the lead cause of skin allergies and severe dermatitis among farmers and rural population. It is an invasive obnoxious weed capable of surviving extreme environmental conditions and various parts of this plant are reported to cause severe contact allergies in humans due to the presence of high concentrations of toxic sesquiterpene lactones viz. parthenin. It can stimulate numerous cellular and immune responses that may translate into Oxidative stress, allergies, and inflammation. The effect of P. hysterophorus flower extract was evaluated on cell viability, oxidative stress and inflammation in A549 lung cancer cell line by spectrophotometric and reverse transcriptase-polymerase chain reaction methods. Schrodinger software based docking was performed for possible interactions studies. The A549 cells treated with P. hysterophorus flower extract favors increase in cell viability, reactive oxygen species generation. The mRNA expression of proinflammatory cytokines such as IFN-γ, TNF-α, and IL-1β was significantly increased whereas no change in IL-18 expression was observed. Significant increase in protein expression of NF-κB was observed, suggesting the role of NF-κB signalling in allergic responses. The docking studies demonstrated the potential interaction between Parthenin and NF-κB/IL-1β/ IL-18 suggesting their activation leading to inflammation. The current study emphasize that P. hysterophorus mediates oxidative stress, and inflammatory process via alterations in expression of proinflammatory cytokines such as IL-1β, IFN-γ through NF-κB activation which was also confirmed in docking studies. Cellular and molecular mechanisms involved in pathogenesis of allergic/chronic inflammation and severe dermatitis need to be further investigated to identify specific binding partners responsible for severe inflammation which can provide some leads in developing effective targets against severe dermatitis and skin allergies.

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“…Parthenium weed has negative effects on humans, both directly by impacting human health, and indirectly by affecting crop and livestock production (Adkins and Shabbir, 2014;Kaur et al, 2014). In humans, allergic reactions to parthenium weed can result in an acute form of contact dermatitis, bronchitis, asthma, and hay fever (Adkins and Shabbir, 2014;Kaur et al, 2014;Lakshmi and Srinivas, 2012;McConnachie et al, 2011). It is estimated that up to 73% of people are sensitive to parthenium weed with females being twice more sensitive than males (Khari and Kumar, 2018).…”

Section: Introductionmentioning

confidence: 99%

Management strategies for the noxious invasive parthenium weed (Parthenium hysterophorus L.) in Uganda

Natukunda¹,

Natukunda²,

Kyeyune³

et al. 2020

Afr. J. Agric. Res.

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Parthenium weed is a noxious invasive species that has negative effects on agriculture and also causes allergic reactions in humans. The goal of this study was to evaluate several management strategies for parthenium weed and assess the suitability of each control measure for farmers, and other stakeholders in Uganda. Field experiments were conducted in a completely randomized design, and the quadrat sampling method used to assess the effect of mulching, foliar application of table salt solution, hand pulling, slashing, hand hoeing, foliar herbicide application, and integrated weed management on parthenium plant populations. All tested weed management strategies except foliar herbicide application significantly (P0.05) reduced parthenium plant populations, with parthenium weed counts for treated plots reducing on subsequent data collection days. The experimental data showed that parthenium plant populations increased for the untreated plot overtime. The authors recommend that a combination of multiple weed control measures (integrated weed management) are utilized for effective management of parthenium weed in Uganda to reduce limitations that result when one management strategy is used singly. This study informs farmers, the general public, and researchers how to effectively control parthenium weed, contributing to reduction of the numerous negative effects of parthenium weed on human livelihoods.

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Parthenium the terminator: An update

Abstract: Parthenium dermatitis is a distressing dermatitis caused by the air borne allergen of the Compositae weed Parthenium hysterophorus. Uncommon presentations, newer insights in pathogenesis and management of this “scourge” are discussed in this article.

Cited by 20 publications

References 56 publications

Parthenium Dermatitis With Deck-Chair Sign

Parthenium Dermatitis With Deck-Chair Sign

Parthenium hysterophorus mediated inflammation and hyper‐responsiveness via NF‐κB pathway in human A549 lung cancer cell line

Management strategies for the noxious invasive parthenium weed (Parthenium hysterophorus L.) in Uganda

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