Pars plana-Vitrektomie zur Behandlung der chronischen Uveitis

Heimann, Klaus; U, Tavakolian; Paulmann, H.; Morris, Robert E.

doi:10.1007/978-3-642-88589-1_46

Cited by 3 publications

(3 citation statements)

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“…Zu einer postoperativen Netzhautablosung karn es bei 6 Patienten, wobei es sich in 4 Augen urn eine Reamotio infolge proliferativer Vitreoretinopathie handelte. In 2 Augen (4%) trat eine Ablatio retinae als (3,5,6,11), ist das funktionelle Resultat bei praoperativ schon eingetretener Netzhautablosung deutlich schlechter (4, 5, 11) (Abb. 2).…”

Section: Ergebnisseunclassified

Vitrektomie in der Behandlung von Augen mit komplizierter Uveitis

Thumann¹,

Bartz‐Schmidt²,

Esser³

et al. 1997

Klin Monatsbl Augenheilkd

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Section: Ergebnisseunclassified

Vitrektomie in der Behandlung von Augen mit komplizierter Uveitis

Thumann¹,

Bartz‐Schmidt²,

Esser³

et al. 1997

Klin Monatsbl Augenheilkd

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“…-Alle 3 Fälle von postoperativer Phthise (5,5%) zeigten eine relativ kurze Erkrankungsdauer von 1-5 Jahren, hatten präoperativ eine Tension unter 10 mm Hg, standen unter einer systemischen Therapie von Steroiden oder Cytostatica, starnmten aus der Gruppe der einfachen oder kombinierten Zyklitiden und wiesen vaskulitische Veranderungen mit oder ohne PVR auf. Wir stimmen mit den anderen Autoren daB die funktionellen Resultate der Vitrektornie bei chronisch endogenen Uveitiden erstaunlich gut sind (1, 3, 4, 5, 6, 7, 10), daB die Rezidive seltener werden (1, 2, 3, 4) und die postoperative medikarnentose Therapie häufig drastisch reduziert oder Uberhaupt weggelassen werden kann (2,4,6,7,10). Auffallend in unserem Krankengut ist die dominierende Frequenz der einfachen oder kombinierten Zyklitiden.…”

Section: Resultateunclassified

Pars-plana Vitrektomie bei chronischer Uveitis

Klöti

1988

Klin Monatsbl Augenheilkd

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Statistical analysis of 54 eyes with chronical endogenous uveitis, mostly juvenile, treated with simple or combined pars plana vitrectomy. Most striking is the high frequency of localized or combined cyclitis with good functional results, although complications of the disease (retinal detachment, vasculitis, PVR, macular damage) are extremely frequent in cyclitis, and this group also includes, three cases of postoperative phthisis. The best argument in favor of an chronic uveitis is the fact that an overwhelming majority of the patients were able to switch from rigorous systemic preoperative medication to simple eye drops or no treatment at all.

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“…An "autoimmune disease" would not explain the good prognosis of vitrectomy [183]. Although irrigation of the vitreous cavity temporarily relieves autoimmune uveitis by removing the "immunologic memory" from the vitreous cavity [184][185][186][187][188][189][190]; in these cases, it does not have the lasting and significant effect that it has in ERU [16,191]. Thus, the autoimmune reactions in equine eyes are only immune phenomena accompanying the causative leptospiral infection.…”

Section: Leptospirosis and Autoimmune Diseasementioning

confidence: 99%

Infectious Uveitis in Horses and New Insights in Its Leptospiral Biofilm-Related Pathogenesis

2022

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Uveitis is a sight-threatening eye disease in equids known worldwide that leads to considerable pain and suffering. By far the most common type of uveitis in Germany and neighboring countries is classical equine recurrent uveitis (ERU), which is caused by chronic intraocular leptospiral infection and is the main cause of infectious uveitis in horses. Other infectious causes are extremely rare and are usually clinically distinguishable from ERU. ERU can be treated very effectively by vitreous cavity lavage (vitrectomy). For proper indications of this demanding surgery, it is necessary to differentiate ERU from other types of uveitis in which vitrectomy is not helpful. This can be conducted on the basis of anamnesis in combination with ophthalmologic findings and by aqueous humor examination. During vitrectomy, vitreous material is obtained. These vitreous samples have historically been used for numerous etiologic studies. In this way, a chronic intraocular leptospiral infection has been shown to be the cause of typical ERU and, among other findings, ERU has also been recognized as a biofilm infection, providing new insights into the pathogenesis of ERU and explaining some thus far unexplainable phenomena of ERU. ERU may not only have transmissible aspects to some types of uveitis in humans, but may also serve as a model for a spontaneously occurring biofilm infection. Vitreous material obtained during therapeutically indicated vitrectomy can be used for further studies on in vivo biofilm formation, biofilm composition and possible therapeutic approaches.

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Pars plana-Vitrektomie zur Behandlung der chronischen Uveitis

Cited by 3 publications

References 1 publication

Vitrektomie in der Behandlung von Augen mit komplizierter Uveitis

Vitrektomie in der Behandlung von Augen mit komplizierter Uveitis

Pars-plana Vitrektomie bei chronischer Uveitis

Infectious Uveitis in Horses and New Insights in Its Leptospiral Biofilm-Related Pathogenesis

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