Pars Plana Vitrectomy in Advanced Coats’ Disease

Müftüoğlu, Gülipek; Gülkılık, Gökhan

doi:10.1159/000323616

Cited by 27 publications

(7 citation statements)

References 5 publications

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“…1,24,25,26 Additional internal or external subretinal fluid drainage also facilitates the application of laser photocoagulation or cryotherapy. Mutfuoglu ve Gulkilik 25 achieved positive anatomic and functional outcomes in 5 patients with PPV, internal subretinal fluid drainage and silicone oil tamponade. Despite postoperative anatomic success, functional success may be achieved in a small number of patients.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Follow-Up and Treatment Results in Coats’ Disease

Cebeci

Bayraktar

Yılmaz

et al. 2016

tjo

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Objectives:The aim of this study was to evaluate the clinical features, follow-up and treatment results of patients diagnosed with Coats’ disease.Materials and Methods: Medical records of 27 patients diagnosed with Coats’ disease in our clinic were reviewed retrospectively. All patients underwent complete ophthalmological examination and fundus photography was taken. Disease stage and treatment methods used were recorded.Results:Twenty-seven eyes of 27 patients were included in the study. Mean age was 9.03 years; 21 patients were male and 6 were female. Three patients were older than 18 years old. Based on the Shields classification, 1 (3.7%) eye was stage 2A, 4 (14.8%) eyes were stage 2B, 6 (22.2%) were stage 3A1, 3 (11.1%) were stage 3A2, 1 (3.7%) was stage 3B, 4 (14.8%) were stage 4 and 8 (29.6%) were stage 5. Fourteen patients underwent treatment, 12 of whom had combined therapy. The most common treatment modalities were laser photocoagulation and cryotherapy. Encircling band was done in one patient and pars plana vitrectomy in 3 patients. Enucleation was done in 5 patients.Conclusion:Coats’ disease is a chronic disease and main goal of treatment is to eliminate the vascular anomalies and their complications using repetitive combination therapies. Treatment in the early stages can lead to functional success, and in advanced stages can result in a salvageable eye.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Follow-Up and Treatment Results in Coats’ Disease

Cebeci

Bayraktar

Yılmaz

et al. 2016

tjo

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“…31 The latest studies have shown that the increasing use of anti-VEGF agents can also lead to a new application for the treatment of Coats disease. [32][33][34] The effect has been shown the raised VEGF level in aqueous humor and increases significantly as the disease prolongs. 35 The basic science behind the histopathologic review has depicted that macrophages in the subretinal space and which results in raised vascular permeability, in addition to this leads to angiogenesis due to increased expression of VEGF.…”

Section: Discussionmentioning

confidence: 99%

The detection of COAT’s disease at its early stage and management

Shah¹

2021

AOVS

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Coats disease is the potential leading cause of blindness which is an idiopathic disorder characterized by progressive deposition of intraretinal or subretinal exudates and abnormal development of retinal vasculatures known as telangiectasia that leads to exudative retinal detachment. The case shows unilateral involvement of the eye and primarily at an early age of 12 years. The cause of the disease is idiopathic and if associated with other genetic disorders emphasizes the deposition of a genetic component. The underlying histopathological problem is thought due to the abnormal permeability of capillary endothelial cells of the retina. The complications of long-standing disease may progress to total retinal detachment, leukocoria, painful Glaucoma and can be hard to differentiate from retinoblastoma. The diagnostic tools are indirect ophthalmoscopy, fluorescein angiography, CT scan, and MRI. The treatment depends on the closure of abnormal leaking vessels of the retina which is laser therapy and anti-VEGF at its early stage. The advanced stage requires surgical therapy such as scleral buckling, pars plana vitrectomy, and anterior vitrectomy for reattachment of the retina or pre retinal membrane. A careful selection therapy showed a 70% improvement in the clinical course of the disease

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“…1 A retinal cyst without retinal detachment was noted in a case of Coats' disease. 2 We describe an idiopathic asymptomatic giant retinal cyst.…”

Section: Introductionmentioning

confidence: 96%