2021
DOI: 10.1016/j.plipres.2021.101117
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PARPs in lipid metabolism and related diseases

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Cited by 58 publications
(17 citation statements)
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References 388 publications
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“…As for lipid localization/transport pathways, we focused on Abca1 , Hdlbp , Osbpl9 , and Pitpnc1 . Abca1 is a transporter central to the synthesis of HDL by mediating the efflux of cholesterol and phospholipids to lipoproteins [ 23 ], and low expression levels of Abca1 reduce cholesterol flux into bile, as well as toward LDL [ 24 ]. Hdlbp affects the metabolism of major lipoproteins and specifically binds HDL molecules, which may function in the removal of excess cellular cholesterol [ 25 ].…”
Section: Discussionmentioning
confidence: 99%
“…As for lipid localization/transport pathways, we focused on Abca1 , Hdlbp , Osbpl9 , and Pitpnc1 . Abca1 is a transporter central to the synthesis of HDL by mediating the efflux of cholesterol and phospholipids to lipoproteins [ 23 ], and low expression levels of Abca1 reduce cholesterol flux into bile, as well as toward LDL [ 24 ]. Hdlbp affects the metabolism of major lipoproteins and specifically binds HDL molecules, which may function in the removal of excess cellular cholesterol [ 25 ].…”
Section: Discussionmentioning
confidence: 99%
“…The PARP family of 17 proteins is involved in a wide range of biological processes [ 43 , 44 ], and many of the 17 PARPs are involved in lipid metabolism, including PARP2 and PARP7 [ 43 ]. In our RNA-Seq data, four PARP genes were significantly up-regulated ( PARP9 , PARP10 , PARP12 , and PARP14 ; Supplementary Table S2 ).…”
Section: Discussionmentioning
confidence: 99%
“…Hepatic FAs oxidation (FAO), commonly induced by low-circulating glucose concentrations, occurs mainly in the mitochondria to provide energy, which is controlled by PPARα [75]. FAs are transported into the mitochondria via CPT1 situated in the outer mitochondrial membrane and preferably metabolized via peroxisomal β-oxidation.…”
Section: Hepatic Fas Oxidationmentioning
confidence: 99%