Paroxysmal Sympathetic Hyperactivity in Stroke

Muraoka, Shinsuke; Kumagai, Yoshinao; Koketsu, Naoki; Araki, Yoshio; Saito, Ryuta

doi:10.1016/j.wneu.2023.07.002

Cited by 1 publication

(1 citation statement)

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“…In addition to exploring pharmacological interventions, researchers have also focused on addressing the complications that can arise from aSAH. Paroxysmal sympathetic hyperactivity was considered a potential complication of aSAH, which was life-threatening and associated with severe brain injury but lacked specific clinical symptoms ( 83 ). Mathew et al ( 84 ) performed a prospective study that demonstrated a correlation between paroxysmal sympathetic hyperactivity after severe traumatic brain injury and more extended hospital stay, worse Disability Rating Scale at discharge, higher mortality, and unfavorable outcomes (including death, vegetative state, or severe disability).…”

Section: Potential Drug Therapy Approaches In Intracranial Aneurysmsmentioning

confidence: 99%

Potential application of peripheral blood biomarkers in intracranial aneurysms

Wu,

Zhao,

Kang

et al. 2023

Front. Neurol.

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Intracranial aneurysm (IA) counts are increasing yearly, with a high mortality and disability after rupture. Current diagnosis and treatment rely on costly equipment, lacking effective indicators for progression prediction and specific drugs for treatment. Recently, peripheral blood biomarkers, as common clinical test samples, reflecting the immune and inflammatory state of the body in real-time, have shown promise in providing additional information for risk stratification and treatment in IA patients, which may improve their outcomes after aneurysm rupture through anti-inflammatory therapy. Therefore, this paper reviewed the progress of potential biomarkers of IAs, including inflammatory blood indicators, cytokines, and blood lipids, aiming to aid individual management and therapy of aneurysms in clinical practices.

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Section: Potential Drug Therapy Approaches In Intracranial Aneurysmsmentioning

confidence: 99%