Paroxysmal EEG abnormalities and epilepsy in pervasive developmental disorders: Follow-up study until adolescence and beyond

Kawasaki, Yoko; Shinomiya, Mieko; Takayanagi, Mizuho; Niwa, Shin‐Ichi

doi:10.1016/j.braindev.2010.06.004

Cited by 9 publications

(3 citation statements)

References 15 publications

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“…On the other hand, in patients with autism spectrum disorders (ASDs), EEG paroxysmal abnormalities are frequently recorded. Recent research has reported that the majority of paroxysmal abnormalities at the time of epilepsy onset appeared in the frontal area [29]. Similarly, current research has shown that the spike patterns in ASDs of epilepsy patients differ from those in patients without epilepsy [30].…”

Section: Relationship Between Frontal Spikes and Neuropsychological Imentioning

confidence: 65%

Cognitive and Behavioral Consequences in Children with Epilepsy: The Relationship between Paroxysmal EEG Abnormalities and Cognitive/Behavioral Disturbances

Doshi

Kanemura

Aihara³

2013

Pediat Therapeut

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A relationship between epilepsy and impairment of neuropsychological functioning has been observed in children with epilepsy. Interictal epileptiform discharges on electroencephalograms (EEGs) are regarded as a correlate of persistent pathological neuronal discharges. Paroxysmal abnormalities in the frontal area may be associated with neuropsychological impairments. Investigations of paroxysmal EEG abnormalities are also needed. Subclinical discharges contribute to the psychosocial problems of children with epilepsy. A combination of spike rate and extended periods of high-frequency paroxysmal EEG abnormalities may predict the atypical evolution of benign childhood epilepsy with centrotemporal spikes. In addition, children with epilepsy with continuous spike-waves during slow sleep have cognitive and behavioral disturbances that are correlated with frequent epileptiform discharges. On the other hand, several studies have suggested that EEG characteristics, especially the localization of paroxysmal discharges, might be important predictors for subsequent epilepsy. Patients with febrile seizure presenting with frontal paroxysmal EEG abnormalities may be at risk for epilepsy. In addition, the frontal paroxysms may indicate a higher risk of epilepsy in autism spectrum disorders. Moreover, the location of paroxysmal EEG abnormalities correlates with behavioral disturbances. Frontal EEG paroxysms may be associated with a higher risk of developing atypical clinical features such as seizure recurrence and cognitive/behavioral problems. Previous and current studies suggest that a combination of spike frequency, extended periods of high-frequency paroxysmal EEG abnormalities, and frontal EEG focus might predict atypical clinical manifestations, such as neuropsychological impairments, and ultimate neuropsychological outcome in children with epilepsy. To prevent these disturbances and problems in children with epilepsy, treatment to remit seizures and EEG abnormalities as soon as possible may be required to achieve the optimal prognosis for children with cognitive/behavioral problems.

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Section: Relationship Between Frontal Spikes and Neuropsychological Imentioning

confidence: 65%

Cognitive and Behavioral Consequences in Children with Epilepsy: The Relationship between Paroxysmal EEG Abnormalities and Cognitive/Behavioral Disturbances

Doshi

Kanemura

Aihara³

2013

Pediat Therapeut

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“…Las alteraciones EEG focales son más frecuentes en las regiones frontales y temporales, seguidas de las regiones centrales, centro-temporo-parietales, occipitales y parietales. Durante la niñez, los focos pueden variar de localización, pero parece que hacia la adolescencia son más predominantes en el área frontal (García, 2009;Yasuhara, 2010;Kawasaki et al, 2010). En este reporte las regiones cerebrales con mayor compromiso fueron las áreas frontales y parietales cuando se presentaba un solo foco anormal, sin embargo, cuando se presentaban en más de un foco de anormalidad por orden de frecuencia se encontró las regiones fronto-centroparietal, fronto-centro-parieto-temporal y las centro-temporo-parietal, de la misma manera, la forma bilateral fue la más presente, cuando se presentaba en un solo hemisferio el lado ligeramente más comprometido fue el izquierdo.…”

Section: Resultsunclassified

Hallazgos en el electroencefalograma digital de los trastornos del espectro autista. Mérida, Venezuela. 2020-2021

Uzcátegui

Moreno²

2022

GICOS

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Introducción: el trastorno del espectro autista (TEA) se caracteriza por la triada de Wing, alteración en la comunicación, interacción social y flexibilidad e imaginación (OMS, 2019, Uzcátegui y Moreno, 2021). Objetivo: describir los principales hallazgos de los electroencefalogramas (EEG) digitales de los TEA que acudieron a la consulta de neuropediatría en diferentes instituciones sanitarias de Mérida-Venezuela durante el año 2020-2021. Metodología: se realizó un estudio de tipo cuantitativo, descriptivo y transversal. La muestra estuvo conformada por 109 sujetos mayores de 2 años y menores de 16 años que presentaban clínica de TEA. Resultados: la anormalidad que fue más frecuentemente encontrada fueron los paroxismos focales 32 (70%) específicos 31 (68,88%) bilaterales 19 (42,22%). Los EEG digitales son una herramienta fundamental al momento de valorar la actividad bioeléctrica cerebral en los TEA, aunque no existe un patrón único asociado a estos, se observan cambios variables dependiendo de la variabilidad del espectro. Conclusión: entre los hallazgos del EEG digital más frecuente en los TEA se encuentra relacionada con la actividad epileptiforme, no constituyendo un patrón único, dependiendo de muchos factores, entre estos la edad y la variabilidad en el espectro de TEA que presente el niño.

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“…In children with both ASDs and epilepsy, the foci of paroxysmal discharges are frequently found in the frontal lobes and/or temporal lobes [12][13][14][15][16][17].…”

Section: Epilepsy and Eeg Abnormalities In Asdsmentioning

confidence: 99%

SPECT findings in autism spectrum disorders and medically refractory seizures

Sasaki

2015

Epilepsy & Behavior

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Paroxysmal EEG abnormalities and epilepsy in pervasive developmental disorders: Follow-up study until adolescence and beyond

Cited by 9 publications

References 15 publications

Cognitive and Behavioral Consequences in Children with Epilepsy: The Relationship between Paroxysmal EEG Abnormalities and Cognitive/Behavioral Disturbances

Cognitive and Behavioral Consequences in Children with Epilepsy: The Relationship between Paroxysmal EEG Abnormalities and Cognitive/Behavioral Disturbances

Hallazgos en el electroencefalograma digital de los trastornos del espectro autista. Mérida, Venezuela. 2020-2021

SPECT findings in autism spectrum disorders and medically refractory seizures

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