SPECT findings in autism spectrum disorders and medically refractory seizures

Sasaki, Masayuki

doi:10.1016/j.yebeh.2014.10.033

Cited by 5 publications

(6 citation statements)

References 32 publications

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“…Studies have reported increased GI in the frontal and temporal lobes in adults with schizophrenia [64][65][66][67] and in the frontal lobe of children with autism. 68 These findings suggest that parental psychological distress in the setting of lower SES across the lifespan may play a role in the complex cerebral cortical folding process, and this risk may have a fetal onset.…”

Section: Jama Network Open | Imagingmentioning

confidence: 85%

“…This accelerated brain gyrification in lower SES populations may be in part associated with parental stress. Converging evidence points to increased cerebral cortical folding in fetuses, 40 children, and adults [64][65][66][67][68] exposed to prenatal stress and other neuropsychiatric disorders, including autism and schizophrenia. Studies have reported increased GI in the frontal and temporal lobes in adults with schizophrenia [64][65][66][67] and in the frontal lobe of children with autism.…”

Section: Jama Network Open | Imagingmentioning

confidence: 99%

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Association Between Socioeconomic Status and In Utero Fetal Brain Development

Kapse

Andersen

et al. 2021

JAMA Netw Open

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IMPORTANCE Children raised in settings with lower parental socioeconomic status are at increased risk for neuropsychological disorders. However, to date, the association between socioeconomic status and fetal brain development remains poorly understood.OBJECTIVE To determine the association between parental socioeconomic status and in vivo fetal brain growth and cerebral cortical development using advanced, 3-dimensional fetal magnetic resonance imaging. DESIGN, SETTING, AND PARTICIPANTSThis cohort study of fetal brain development enrolled 144 healthy pregnant women from 2 low-risk community obstetrical hospitals from 2012 through 2019 in the District of Columbia. Included women had a prenatal history without complications that included recommended screening laboratory and ultrasound studies. Exclusion criteria were multiple gestation pregnancy, known or suspected congenital infection, dysmorphic features of the fetus, and documented chromosomal abnormalities. T2-weighted fetal brain magnetic resonance images were acquired. Each pregnant woman was scanned at up to 2 points in the fetal period. Data were analyzed from June through November 2020. EXPOSURES Parental education level and occupation status were documented. MAIN OUTCOMES AND MEASURES Regional fetal brain tissue volume (for cortical gray matter, white matter, cerebellum, deep gray matter, and brainstem) and cerebral cortical features (ie, lobe volume, local gyrification index, and sulcal depth) in the frontal, parietal, temporal, and occipital lobes were calculated. RESULTS Fetal brain magnetic resonance imaging studies were performed among 144 pregnant women (median [interquartile range] age, 32.5 [27.0-36.1] years) with gestational age from 24.0 to 39.4 weeks; 75 fetuses (52.1%) were male, and 69 fetuses (47.9%) were female. Higher parental education level was associated with significantly increased volume in the fetal white matter

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Section: Jama Network Open | Imagingmentioning

confidence: 85%

Section: Jama Network Open | Imagingmentioning

confidence: 99%

Association Between Socioeconomic Status and In Utero Fetal Brain Development

Kapse

Andersen

et al. 2021

JAMA Netw Open

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“…Cerebral hypoperfusion has been demonstrated in ASD as compared to healthy controls in many parts of the brain, typically using positron emission tomography (PET) or single-photon emission computed tomography (SPECT) (Boddaert and Zilbovicius 2002, Galuska et al 2002, Sasaki 2015, Zilbovicius et al 1995, 2000. Further scanning methods such as fMRI were also adopted in ASD neuro-imaging with encouraging results (Dichter 2012, Jann et al 2015, Philip et al 2012.…”

Section: Evidence For Cerebral Hypoperfusionmentioning

confidence: 99%

“…Recent molecular research has identified genetic and epigenetic factors that can lead to, or contribute to the development of ASD (Nguyen et al 2010, Veenstra-VanderWeele andCook 2004). Sasaki (2015) reported that localized areas of hypoperfusion, e.g., in prefrontal lobes, cingulate gyrus, and temporal lobes, as identified by SPECT, could be caused by aberrant neuro-nal connectivity. The hypoperfusion could then reflect receptor, neurotransmitter or other neuronal defects (Homs et al 2016, Huguet et al 2013, Sasaki et al 2015 which is analogues to the temporoparietal hypoperfusion observed on cerebral SPECT images of patients with Alzheimer's disease (Jagust et al 2001).…”

Section: Possible Causes Of the Decreased Rcbf In Asdmentioning

confidence: 99%

Cerebral hypoperfusion in autism spectrum disorder

Bjørklund

Kern

Urbina

et al. 2018

Acta Neurobiologiae Experimentalis

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Cerebral hypoperfusion, or insufficient blood flow in the brain, occurs in many areas of the brain in patients diagnosed with autism spectrum disorder (ASD). Hypoperfusion was demonstrated in the brains of individuals with ASD when compared to normal healthy control brains either using positron emission tomography (PET) or single-photon emission computed tomography (SPECT). The affected areas include, but are not limited to the: prefrontal, frontal, temporal, occipital, and parietal cortices; thalami; basal ganglia; cingulate cortex; caudate nucleus; the limbic system including the hippocampal area; putamen; substantia nigra; cerebellum; and associative cortices. Moreover, correlations between symptom scores and hypoperfusion in the brains of individuals diagnosed with an ASD were found indicating that the greater the autism symptom pathology, the more significant the cerebral hypoperfusion or vascular pathology in the brain. Evidence suggests that brain inflammation and vascular inflammation may explain a part of the hypoperfusion. There is also evidence of a lack of normal compensatory increase in blood flow when the subjects are challenged with a task. Some studies propose treatments that can address the hypoperfusion found among individuals diagnosed with an ASD, bringing symptom relief to some extent. This review will explore the evidence that indicates cerebral hypoperfusion in ASD, as well as the possible etiological aspects, complications, and treatments.

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“…The present findings supported our hypothesis, in accord with the proposed prefrontal dysfunction in pediatric ASD identified by other imaging modalities, such as functional magnetic resonance imaging (fMRI) and single-photon emission computed tomography (SPECT). Previous SPECT studies reported localized areas of hypoperfusion, which may be correlated with focal reductions in function observed in the prefrontal lobes, cingulate gyrus, superior temporal gyrus, and mesial temporal lobes of individuals with ASD [43]. In ASD, fMRI studies of motor and cognitive interference inhibition and switching reported abnormalities in fronto-striato-parietal areas, including dorsolateral prefrontal cortex and ventrolateral prefrontal cortex [44, 45].…”

Section: Discussionmentioning

confidence: 99%

Reduced prefrontal hemodynamic response in pediatric autism spectrum disorder measured with near-infrared spectroscopy

Uratani¹,

Ota

Iida

et al. 2019

Child Adolesc Psychiatry Ment Health

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Background Functional neuroimaging studies suggest that prefrontal cortex dysfunction is present in people with autism spectrum disorder (ASD). Near-infrared spectroscopy is a noninvasive optical tool for examining oxygenation and hemodynamic changes in the cerebral cortex by measuring changes in oxygenated hemoglobin. Methods Twelve drug-naïve male participants, aged 7–15 years and diagnosed with ASD according to DSM-5 criteria, and 12 age- and intelligence quotient (IQ)-matched healthy control males participated in the present study after giving informed consent. Relative concentrations of oxyhemoglobin were measured with frontal probes every 0.1 s during the Stroop color-word task, using 24-channel near-infrared spectroscopy. Results Oxyhemoglobin changes during the Stroop color-word task in the ASD group were significantly smaller than those in the control group at channels 12 and 13, located over the dorsolateral prefrontal cortex (FDR-corrected P: 0.0021–0.0063). Conclusion The results suggest that male children with ASD have reduced prefrontal hemodynamic responses, measured with near-infrared spectroscopy.

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SPECT findings in autism spectrum disorders and medically refractory seizures

Cited by 5 publications

References 32 publications

Association Between Socioeconomic Status and In Utero Fetal Brain Development

Association Between Socioeconomic Status and In Utero Fetal Brain Development

Cerebral hypoperfusion in autism spectrum disorder

Reduced prefrontal hemodynamic response in pediatric autism spectrum disorder measured with near-infrared spectroscopy

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