Paroxetine’s effect on the proinflammatory cytokine stimulation and intracellular signaling pathways in J774.2 cells

Önal, Harika Topal; Yetkin, Derya; Ayaz, Furkan

doi:10.1007/s00210-023-02669-1

Naunyn-Schmiedeberg's Arch Pharmacol

2023

DOI: 10.1007/s00210-023-02669-1

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Paroxetine’s effect on the proinflammatory cytokine stimulation and intracellular signaling pathways in J774.2 cells

Harika Topal Önal,

Derya Yetkin,

Furkan Ayaz

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2024

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Cited by 1 publication

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Anti-inflammatory activity of benidipine hydrochloride in LPS-activated mammalian macrophages

Servi,

Korkmaz,

Ayaz

2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Benidipine hydrochloride (BH), a medication frequently used by the hypertension patients, acts as a calcium channel blocker. However, its effects on the macrophages have not been investigated thus far. Our goal was investigating the effect of the benidipine hydrochloride to modulate the J774.2 murine macrophage cells inflammatory activity. Our results suggest that in the absence of a standard stimulating agent (LPS) BH did not stimulate the macrophages to produce pro-inflammatory IL-12p40, TNF-α, GM-CSF and IL-6 cytokines. However, when BH was administrated to the cells in the presence of LPS as stimulating agent, it reduced the production of these pro-inflammatory cytokines. Therefore, it had anti-inflammatory activity. At the clinical setting this study suggests that BH can be utilized as hypertension drug that can suppress the inflammation associated with it.

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Anti-inflammatory activity of benidipine hydrochloride in LPS-activated mammalian macrophages

Servi,

Korkmaz,

Ayaz

2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Paroxetine’s effect on the proinflammatory cytokine stimulation and intracellular signaling pathways in J774.2 cells

Cited by 1 publication

References 41 publications

Anti-inflammatory activity of benidipine hydrochloride in LPS-activated mammalian macrophages

Anti-inflammatory activity of benidipine hydrochloride in LPS-activated mammalian macrophages

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