Anti-inflammatory activity of benidipine hydrochloride in LPS-activated mammalian macrophages
Hülya Servi,
Tanya Beril Korkmaz,
Furkan Ayaz
Abstract:Benidipine hydrochloride (BH), a medication frequently used by the hypertension patients, acts as a calcium channel blocker. However, its effects on the macrophages have not been investigated thus far. Our goal was investigating the effect of the benidipine hydrochloride to modulate the J774.2 murine macrophage cells inflammatory activity. Our results suggest that in the absence of a standard stimulating agent (LPS) BH did not stimulate the macrophages to produce pro-inflammatory IL-12p40, TNF-α, GM-CSF and IL… Show more
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