Parotid Salivary Gland Basal Cell Adenocarcinoma in a Big-eared Opossum (Didelphis aurita)

Díaz‐Delgado, Josué; Coimbra, Amanda Aparecida Cardoso; Santos-Cirqueira, Cinthya dos; Sanches, Tatiana; Guerra, Juliana Mariotti; Oliveira, Antônia Santos; Loretto, C. Di; Zwarg, Ticiana; Réssio, Rodrigo Albergaria; Rivas, Luana; Sansone, Marcelo; Nagamori, Filipe Onishi; Kanamura, Cristina; Gonçalves, Pedro; Fernandes, Natália Coelho Couto de Azevedo; Groch, Kátia R.; Catão‐Dias, José Luiz

doi:10.1016/j.jcpa.2017.12.010

Cited by 3 publications

(4 citation statements)

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“…IHC has been utilized in the differentiation of MECs. Epithelial cells display diffuse positivity for cytokeratin not only in MECs but in adenocarcinomas, 6 pleomorphic adenomas, 7 basal cell adenocarcinomas, 5 and squamous cell carcinomas. 13 Peripheral cells in MECs can stain positive for vimentin, 6 and 20-25% of epithelial cells in MECs co-express vimentin and glial fibrillary acidic protein.…”

Section: Research-article2022mentioning

confidence: 99%

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High-grade mucoepidermoid carcinoma of the salivary gland in a bull

et al. 2022

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Salivary gland neoplasia is uncommon in veterinary species and has rarely been reported in cattle. Adenocarcinoma, squamous cell carcinoma, and pleomorphic carcinoma have been described in the parotid gland of dairy cows. Here we describe a case of high-grade mucoepidermoid carcinoma in a bull. The bull had a chronic history of caudal mandibular soft tissue swelling. Postmortem examination revealed a 30 × 30-cm mass with a caseonecrotic center, hemorrhage and necrosis of the ipsilateral cervical musculature, osteolysis of the right paracondylar process of the skull and right horn base, pulmonary nodules, and enlarged tracheobronchial lymph nodes. Histology of the mass, lungs, and lymph nodes revealed an invasive neoplasm composed of epithelial cells arranged in nests and ductular structures supported by a spindle cell stroma, with frequent central necrosis. Immunohistochemistry revealed that epithelial cells were diffusely positive for pancytokeratin and p63 with multifocal vimentin positivity; stromal cells were diffusely positive for vimentin and α-SMA. A salivary gland mucoepidermoid carcinoma was diagnosed based on these findings. Although rare, salivary gland neoplasia should be considered a differential diagnosis for mandibular masses in cattle.

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Section: Research-article2022mentioning

confidence: 99%

“…Salivary gland neoplasms are uncommon in all veterinary species, occurring most often in dogs and cats, 11,13 rarely in cattle, 2,16,17 and sporadically in nontraditional species [5][6][7] ; they remain unreported in swine. 13 A retrospective study including almost 600 tumors in cattle over a 45-y period identified no salivary neoplasms.…”

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High-grade mucoepidermoid carcinoma of the salivary gland in a bull

et al. 2022

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“…Although such cases are uncommon, BCAC can occur as a free superficial neoplasm that originates from a minor salivary gland in the oral cavity or upper respiratory tract [10, 18]. In animals, BCAC is considered to be a rare neoplasm, and there have only been four studies about such cases, which included salivary gland tumors in two dogs and a cat [26], tumors of the third eyelid gland in dogs [16] and a bear [23], and a tumor of the parotid salivary gland in a big-eared opossum [3].…”

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confidence: 99%

“…Two other reports described cases in which BCAC arose in the gland of the third eyelid in dogs [16] and or a bear [23]. Finally, a parotid salivary gland BCAC has recently been reported in a big-eared opossum [3].…”

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Basal cell adenocarcinoma on bulbar conjunctiva of third eyelid in a dog

Sano

Miyazaki

Yaegashi

et al. 2019

The Journal of Veterinary Medical Science

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An 8-year-old castrated Toy poodle presented with swelling and proptosis of the right third eyelid caused by an exophytic mass on the bulbar surface. Histologically, the mass was composed of stratified neoplastic basaloid cells, arranged in nests and interconnecting islands, which were mixed with tubular structures. Immunohistochemically, the basaloid cells were positive for p63 and cytokeratin (CK) 14, and the inner epithelial cells of the tubular structures were positive for CK7, CK8, and CK19. According to these findings, the mass was diagnosed as a basal cell adenocarcinoma. Although basal cell adenocarcinoma is rare in animals, it should be included in the list of differential diagnoses for superficial tumors of bulbar conjunctiva of third eyelid in dogs.

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