Basal cell adenocarcinoma on bulbar conjunctiva of third eyelid in a dog

Abstract

An 8-year-old castrated Toy poodle presented with swelling and proptosis of the right third eyelid caused by an exophytic mass on the bulbar surface. Histologically, the mass was composed of stratified neoplastic basaloid cells, arranged in nests and interconnecting islands, which were mixed with tubular structures. Immunohistochemically, the basaloid cells were positive for p63 and cytokeratin (CK) 14, and the inner epithelial cells of the tubular structures were positive for CK7, CK8, and CK19. According to these findings, the mass was diagnosed as a basal cell adenocarcinoma. Although basal cell adenocarcinoma is rare in animals, it should be included in the list of differential diagnoses for superficial tumors of bulbar conjunctiva of third eyelid in dogs.

Challenges in diagnosing canine spindle cell tumours using immunohistochemistry, illustrated by three nonpigmented malignant cases from the nictitating membrane

“…The clinical signs of protrusion of the nictitating membrane with firm or irregular masses of different shades of pink, expanding the nictitating membrane most often in the nonpigmented areas, epiphora and/or conjunctival hyperaemia are as described in former studies on nictitating membrane neoplasia [2,6,[9][10][11][14][15][16][17][18][19][20][21][22][23][24]. The blood blister-like appearance is quite typical for hemangiosarcomas [34].…”

“…The three cases were diagnosed by histopathology and immunohistochemistry. Immunohistochemistry has in the recent years been used in several studies on tumours of the nictitating membrane [14,16,[18][19][20][21][22]24]. It is a valuable tool for the pathologist to further differentiate the type of tumour being analysed and to diagnose more uncommon tumours and new subtypes giving us new knowledge.…”

“…Tumours of the membrana nictitans are quite rare in dogs [1,2], the most common being adenomas or adenocarcinomas arising in the membrana nictitans gland [2][3][4][5]. Other tumours recorded are squamous cell carcinomas [5,6] and papillomas [3,7]; melanomas and melanocytomas [3,8]; hemangiosarcomas [9,10], hemangiomas [3,10,11] and angiokeratomas [12,13]; leiomyoma [14]; mast cell tumours [15]; lymphomas [16,17]; plasmacytomas [18] [G. C. Shaw, personal communication, COPLOW, 2019], myoepitheliomas [19,20], basal cell carcinomas [20][21][22] and complex carcinomas [20]; a transmissible venereal tumour [23]; a malignant peripheral nerve sheath tumour [24]; and a histiocytoma [3].…”

Pathological, histochemical, and immune-histochemical studies on some canine-skin neoplasm at Sharkia province, Egypt

“…According to previous research ( Lee Gross et al ., 2005 ; Ho et al ., 2018), these findings were consistent. According to Sano et al . (2019 ), the BCC mass consisted of tubular structures mixed with stratified neoplastic basaloid cells that were grouped in nests and connected islands.…”

Challenges in diagnosing canine spindle cell tumours using immunohistochemistry, illustrated by three nonpigmented malignant cases from the nictitating membrane.

“…The three cases were diagnosed by histopathology and immunohistochemistry. Immunohistochemistry has in the recent years been used in several studies on tumours of the nictitating membrane [14,16,[18][19][20][21][22]24]. It is a valuable tool for the pathologist to further differentiate the type of tumour being analyzed and to diagnose more uncommon tumours and new subtypes giving us new knowledge.…”