Parotid gland metastasis of a breast cancer

Pérez-Fidalgo, J.A.; Chirivella, Isabel; Laforga, Juan B.; Colio, J M; Blanes, Mar; Baydal, R; Roselló, Susana; De-la-Morena, E; Lluch, Aña

doi:10.1007/s12094-007-0051-2

Cited by 22 publications

(10 citation statements)

References 7 publications

(6 reference statements)

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“…Li et al described that adenocarcinoma, NOS, had an SDC-like area, seen as cribriform epithelioid glands and comedonecrosis, but these areas comprised a small proportion of the tumor cells in the definition of adenocarcinoma, NOS 10 ; therefore, this histological type might not be reliably diagnosed by histology and cytology. Metastasis in the parotid gland has been reported from cutaneous squamous-cell carcinoma, 22 malignant melanoma, 22 Merkel cell carcinoma, 22 rhabdomyosarcoma, 22 renal cell carcinoma, 23 gastric adenocarcinoma, 24 ductal breast carcinoma, 25 and basal cell carcinoma. 26 Such metastatic cancers can be diagnosed cytologically based on clinical findings, with supporting differential diagnosis using immunocytochemistry and the following antibodies: p63 is expressed in squamous-cell carcinoma and in basal cell carcinoma; AR is not expressed in gastric adenocarcinoma or in ductal breast carcinoma; HMB45 is expressed in malignant melanoma; cytokeratin 20 in Merkel cell carcinoma; vimentin in renal cell carcinoma; and desmin in rhabdomyosarcoma.…”

Section: Discussionmentioning

confidence: 99%

Salivary duct carcinoma cytologically diagnosed distinctly from salivary gland carcinomas with squamous differentiation

Kawahara

Harada

Akiba

et al. 2008

Diagnostic Cytopathology

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It has been difficult cytologically to distinguish salivary duct carcinoma (SDC) from high-grade carcinoma. We investigated the microscopic cytological findings, morphometric image analyses, and immunohistochemical features of SDC, focusing on how we achieved an accurate differential diagnosis distinguishing SDC from salivary gland carcinomas with squamous differentiation. Immunohistochemical staining was performed for androgen receptor (AR), gross cystic disease fluid protein-15 (GCDFP15), mammaglobin, human gastric mucin, MUC1, MUC2, p63, and cytokeratin high molecular weight. Of the 13 cases of SDC, 9 cases showed typical cytological findings of sheet clusters with polygonal granular cytoplasm with fine chromatin. The other 4 cases showed unusual cytological findings of a pseudo-papillary cluster or scattered cells only, and the tumor cells showed coarse chromatin. Morphometric image analysis showed that the nucleus area was statistically different between SDC and salivary gland carcinomas with squamous differentiation. AR-positive expression (P = 0.008), GCDFP15-positive expression (P = 0.005) and p63-negative expression (P = 0.001) were effective as SDC-specific markers in immunohistochemistry. An accurate cytological diagnosis of SDC can be determined by immunostaining with AR, GCDFP15, and p63, based on the nuclear findings.

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Section: Discussionmentioning

confidence: 99%

Salivary duct carcinoma cytologically diagnosed distinctly from salivary gland carcinomas with squamous differentiation

Kawahara

Harada

Akiba

et al. 2008

Diagnostic Cytopathology

View full text Add to dashboard Cite

show abstract

“…We compared findings of hematoxylin-eosin and various immunohistochemical stains, also of the parotid gland after parotidectomy. The comparison showed the immunohistochemical features were very important to make an accurate diagnosis as in our case [7].…”

Section: Discussionmentioning

confidence: 73%

“…Although the optimal therapy sequence is unknown, treatment of PTG metastatic disease is a combination of surgical removal of solitary tumors, chemotherapy, and radiation therapy [2,6,7]. Our patient refused the recommended surgical treatment plan and was treated with a superficial lobe parotidectomy, followed by adjuvant radiotherapy and chemotherapy.…”

Section: Discussionmentioning

confidence: 93%

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Synchronous Parotid and Thyroid Gland Metastases from Breast Cancer

2011

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Background: Metastases to the parotid and thyroid glands from breast cancer are rare and have a poor prognosis. Case Report: We present the case of a patient with breast carcinoma and synchronous involvement of both the parotid and thyroid gland, and review the literature on this subject. Conclusion: Metastatic malignancy in clinically suspect thyroid and parotid nodules could be detected more frequently with routine use of fine needle aspiration biopsy.

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“…Among the histologic subtypes most commonly encountered are renal cell carcinoma 6 , breast cancer 7 , lung cancer 8 , and prostate cancer 9 . Rarely reported entities include adrenal neuroblastoma, rhabdomyosarcoma, leiomyosarcoma, hepatocellular carcinoma, liposarcoma, and urachus adenocarcinoma of the urinary bladder [10][11][12][13] .…”

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confidence: 99%

Isolated Late Metastasis from Testicular Seminoma Presenting as a Parotid Gland Mass: Case Report and Review of the Literature

2013

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metastasize to the parotid lymph nodes 2 . Extremely rare neoplasms in the head-and-neck region that have been reported to metastasize to the parotid gland include malignant hemangiopericytoma, atypical fibroxanthoma, Merkel cell carcinoma, epithelioid hemangioendothelioma, and chondrosarcoma [3][4][5] .Parotid gland metastases from carcinomas in sites not in the head and neck are rare. Among the histologic subtypes most commonly encountered are renal cell carcinoma 6 , breast cancer 7 , lung cancer 8 , and prostate cancer 9 . Rarely reported entities include adrenal neuroblastoma, rhabdomyosarcoma, leiomyosarcoma, hepatocellular carcinoma, liposarcoma, and urachus adenocarcinoma of the urinary bladder [10][11][12][13] .Immunohistochemistry has improved the differential diagnosis of such lesions. Germ cell tumours in the testis usually metastasize to retroperitoneal lymph nodes, lungs, liver, and brain. Other lymphatic or organ metastases are rare, especially in the headand-neck area. Nonetheless, a few cases of germ-cell neoplasia metastatic to cervical lymph nodes have been reported in the English-language literature; some of these represented the first manifestation of the primary tumour [14][15][16][17] .Qiu et al. 18 reported the first and only case to date of seminoma metastatic to the parotid gland. Here, we present a similar rare case of a singular late metastasis from a testicular seminoma, presenting as an extensive parotid gland mass 5 years after completion of primary polychemotherapy. CASE DESCRIPTIONA 45-year-old man presented in January 2012 with a large progressive and painless space-occupying lesion that had been present for 6 months in the area of the right mandibular angle. Ultrasonography showed a hypoechoic, inhomogeneous, diffusely perfused intraparotid lesion, 6×4 cm in size [ Figure 1(A,B)]. Computed tomography of the neck, chest, and abdomen with contrast enhancement showed a space-occupying lesion 8.0×7.7 cm in ABSTRACTParotid metastases from non-head-and-neck cancers are rare and may represent a diagnostic and therapeutic challenge. A late metastasis to the parotid gland from a seminoma is an unusual manifestation of disease. A 45-year-old man with a history of testicular seminoma 5 years earlier presented with a rapidly progressing parotid mass. Ultrasonography and computed tomography showed a space-occupying lesion at the angle of the right jaw. The mass was infiltrating into the parotid gland and into the parapharyngeal space. A primary parotid neoplasm was suspected, and panendoscopy combined with open biopsy was performed. Histology examination confirmed a seminoma metastatic to the parotid gland, and comparison with the primary tumour showed identical histology. The patient received chemotherapy for recurrent seminoma in accordance with the pei (cisplatin, etoposide, ifosfamide) protocol. After 4 courses of chemotherapy, salvage radical parotidectomy with removal of all suspicious residual tumour tissue was performed.This case illustrates the difficulties that may be encountered ...

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Parotid gland metastasis of a breast cancer

Cited by 22 publications

References 7 publications

Salivary duct carcinoma cytologically diagnosed distinctly from salivary gland carcinomas with squamous differentiation

Salivary duct carcinoma cytologically diagnosed distinctly from salivary gland carcinomas with squamous differentiation

Synchronous Parotid and Thyroid Gland Metastases from Breast Cancer

Isolated Late Metastasis from Testicular Seminoma Presenting as a Parotid Gland Mass: Case Report and Review of the Literature

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