Salivary duct carcinoma cytologically diagnosed distinctly from salivary gland carcinomas with squamous differentiation

Kawahara, Akihiko; Harada, Hiroshi; Akiba, Jun; Kage, Masayoshi

doi:10.1002/dc.20823

Cited by 31 publications

(38 citation statements)

References 29 publications

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“…42,43 Clinical features Men are more likely (by a factor of three) to receive a diagnosis of salivary duct carcinoma than women, and both sexes present in the fifth to sixth decade. 3,6,12,15 More than a quarter of patients will present with facial nerve dysfunction or paralysis, and more than a third have palpable cervical lymphadenopathy, highlighting the aggressive behaviour of this tumour.…”

Section: Morphological Variantsmentioning

confidence: 99%

Salivary duct carcinoma: what is already known, and can we improve survival?

2012

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Salivary duct carcinoma is an aggressive malignancy with a high mortality rate, which phenotypically resembles high-grade breast ductal carcinoma. The parotid gland is the most common location. Standard treatment is surgery to the primary tumour together with post-operative radiotherapy. Despite this, there is a high rate of local recurrence, cervical nodal involvement and distant metastasis. Chemotherapy is currently considered only for end-stage, disseminated disease; however, current evidence indicates that chemotherapy used with radiotherapy may result in improved disease control and survival.Human epidermal growth factor receptor-2 is a proto-oncogene which is over-expressed in both breast ductal carcinoma and salivary duct carcinoma. Clinical studies of patients with metastatic breast cancer, using trastuzumab, a monoclonal antibody directed against human epidermal growth factor receptor-2, have shown significant efficacy in tumour response, resulting in improved survival. Such advances in immunohistochemistry, and in targeted immunotherapy for breast ductal carcinoma, should be applied to the treatment of salivary duct carcinoma.

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Section: Morphological Variantsmentioning

confidence: 99%

Salivary duct carcinoma: what is already known, and can we improve survival?

2012

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“…The numerous morphometric studies were conducted on digitalized pictures of the cytological and histological samples of different organs and tumors, in human and veterinary medicine . The literature describes a number of nuclear and cellular morphometric parameters, which are shown to be valuable in differentiating malignant cells from the cells of benign tumors …”

Section: Discussionmentioning

confidence: 99%

“…The field of nuclear cell morphometry is an innovative area of study which has had a little evaluation to date in the area of parotid gland tumor aspirates cytology. In the literature, there is only a few works on digital morphometric analysis of cytological smears of parotid gland tumors, with a small number of morphometric parameters that were used in this studies . In our opinion, it is due to the lack of its application in routine clinical setting.…”

Section: Discussionmentioning

confidence: 99%

Parotid gland tumors: Correlation between routine cytology and cytomorphometry by digital image analysis using conventional and newly introduced cytomorphometric parameters

Obad-Kovačević

Kardum-Skelin

Jelić-Puškarić

et al. 2013

Diagnostic Cytopathology

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The objective of this study was to compare qualitative cytomorphology and morphometric characteristics of parotid gland tumor cells, with the aid of a computer-assisted system of image analysis. Routine qualitative cytologic and quantitative morphometric results from 64 parotid gland tumors were compared. Ultrasound (US)-guided fine-needle aspiration (FNA) specimens were taken from 54 patients. Eleven conventionally used morphometric parameters were studied: area, perimeter, convex area, convexity, maximal and minimal radius, length, breadth, form factor (FF), elongation factor, and nuclear- cytoplasmatic (N/C) ratio. Two newly introduced nuclear form factors were also measured: area symmetry factor and perimeter symmetry factor. The following nuclear morphometric parameters were significantly different between malignant and benign tumors: area, perimeter, convex area, convexity, maximal and minimal radius, length, breadth, FF, elongation factor, area symmetry factor, and perimeter symmetry factor. Comparing the cutoff values and receiver operating characteristic (ROC) curves the following nuclear morphometric parameters were found most useful in separating benign from malignant tumors: area, perimeter, convex area, maximal radius, length, and FF. The following whole cell morphometric parameters were significantly different between malignant and benign tumors: minimal and maximal radius, convexity, breadth, FF, and elongation factor. N/C ratio was significantly higher in malignant tumors. The quantitative morphometric analysis is a useful tool in the cytological differentiation between benign and malignant parotid gland tumors. Computerized image analysis may add to morphological evaluation by turning qualitative data into quantitative values.

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“…5 From a practical perspective, strong nuclear staining for AR may be used to support a diagnosis of salivary duct carcinoma. 6 …”

Section: Cytologic Featuresmentioning

confidence: 97%

Salivary Duct Carcinoma

Zante¹,

Jordan²

2011

Pathology Case Reviews

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A case of salivary duct carcinoma of the parotid gland is reported in a 58-year-old man who presented with an enlarged lymph node in the right upper neck and whose only risk factor for malignancy was a history of occupational radiation exposure. Fine needle aspiration biopsy yielded a carcinoma with cytologic features reminiscent of apocrine-type breast carcinoma. Immunohistochemical stains for keratin, androgen receptor, and gross cystic disease fluid protein-15 were all positive. Imaging studies identified an infiltrative mass in the deep lobe of the right parotid gland and multiple pathologically enlarged right cervical lymph nodes. The combination of the clinical presentation, cytologic features, and the results of immunostains was consistent with a diagnosis of salivary duct carcinoma. Total parotidectomy and modified radical neck dissection were subsequently performed and microscopic evaluation confirmed the diagnosis. Salivary duct carcinoma is a clinically aggressive carcinoma with pathological features that resemble high-grade ductal adenocarcinoma of the breast. Most tumors are positive for androgen receptor. Although uncommon, the histologic appearance of salivary duct carcinoma is distinctive. Awareness of this entity is important for accurate diagnosis. Appropriate adjunctive testing may inform clinical management in advanced cases.

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Salivary duct carcinoma cytologically diagnosed distinctly from salivary gland carcinomas with squamous differentiation

Cited by 31 publications

References 29 publications

Salivary duct carcinoma: what is already known, and can we improve survival?

Salivary duct carcinoma: what is already known, and can we improve survival?

Parotid gland tumors: Correlation between routine cytology and cytomorphometry by digital image analysis using conventional and newly introduced cytomorphometric parameters

Salivary Duct Carcinoma

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