Parotid and neck metastases from cutaneous squamous cell carcinoma of the head and neck

Khurana, Vini G.; Mentis, Dianne H.; O’Brien, Christopher J.; Hurst, Tara; Stevens, Graham; Packham, Nicholas A.

doi:10.1016/s0002-9610(99)80326-2

Cited by 106 publications

(129 citation statements)

References 19 publications

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“…The head and neck CSCC that have disseminated into the neck and/or parotid gland have a higher incidence of distant metastatic disease, are biologically more aggressive and histopathological findings show extracapsular spread in 70% of cases, which corresponds to our histopathological analysis (12/24 patients had extracapsular spread). 25 Better disease control could be achieved through encouraging more frequent use of ultrasound and/or MSCT diagnostics in the parotid region as a standard clinical practice. 26 Local extent of disease is the most important prognostic factor for primary head and neck CSCC, and the presence of regional metastases cuts the survival rate in half.…”

Section: Discussionmentioning

confidence: 99%

Significance of clinical stage, extent of surgery and outcome in cutaneous squamous cell carcinoma of the head and neck

Svetina

Lukšić

2013

International Journal of Oral and Maxillofacial Surgery

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Section: Discussionmentioning

confidence: 99%

Significance of clinical stage, extent of surgery and outcome in cutaneous squamous cell carcinoma of the head and neck

Svetina

Lukšić

2013

International Journal of Oral and Maxillofacial Surgery

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“…Khurana et al also reported that positive surgical margins were associated with poor local disease control (P ¼ .02). 28 Similarly, Ch'ng et al reported that margin status had a significantly unfavorable impact on survival (P < .01). 27,29 We acknowledge the many potential biases in comparing outcomes from different treatments delivered over many years and using nonrandomized methodology.…”

Section: >3mentioning

confidence: 96%

Metastatic cutaneous squamous cell carcinoma of the head and neck

Oddone

Morgan

Palme

et al. 2009

Cancer

119

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BACKGROUND:The authors propose a prognostic score model using a prospective study of patients with regional metastatic cutaneous squamous cell carcinoma of the head and neck.METHODS:Two‐hundred fifty patients were analyzed using a competing risks model to identify risk factors for survival. A risk score was obtained using the significant coefficients from the regression model, and cutoff points were determined that separated the score into 3 risk groups (low risk, moderate risk, and high risk).RESULTS:At a median follow‐up of 54 months (range, 1.3‐212 months) 70 of 250 patients (28%) developed recurrent disease: Most were regional recurrences (51 of 70 patients; 73%) in the treated lymph node basin. After regional recurrence, a majority (73%) died of disease. The following 4 variables were associated significantly with survival: immunosuppression (hazard ratio [HR], 3.13; 95% confidence interval [CI], 1.39‐7.05), treatment (HR, 0.32; 95% CI, 0.16‐0.66), extranodal spread (HR, 9.92; 95% CI, 1.28‐77.09), and margin status (HR, 1.85; 95% CI, 1.85‐3.369); and those 4 variables (immuosuppression, treatment, extranodal spread, and margin status) were used to calculate the ITEM score. The 5‐year risk of dying from disease for patients with high‐risk (>3.0), moderate‐risk (>2.6‐3.0), and low‐risk (≤2.6) ITEM scores were 56%, 24%, and 6%, respectively. Fifty‐six of 250 patients (22%) died from another cause.CONCLUSIONS:Patients who underwent surgery and received adjuvant radiotherapy had a better outcome compared with patients who underwent surgery alone. Patients who had moderate‐ or high‐risk ITEM scores, usually because of extranodal spread and involved excision margins, had a poor outcome. The authors recommend considering these patients for inclusion in adjuvant chemoradiotherapy trials. Cancer 2009. © 2009 American Cancer Society.

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“…Positive surgical margin was the only statistically significant factor associated with poor local control (P=0.05) in this study. Khurana et al [14] reported that positive surgical margins were associated with poor local control (P=0.02), as did O'Brien et al, who identified margin positivity as an independent predictor for parotid recurrence [15] .…”

Section: Discussionmentioning

confidence: 89%

“…Several other studies have reported on prognostic factors for predicting local control and survival [1,14,16] . Joseph et al, observed that the involvement of multiple nodes, extracapsular spread, or vascular and perineural invasion were associated with increasing relapse rates [1] .…”

Section: Discussionmentioning

confidence: 99%

Parotid squamous cell carcinoma: Outcome of multidisplinary management

Aboziada

Eisbruch

2012

JST

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Purpose: To evaluate the origin and outcome of parotid squamous cell carcinoma (SCC). Methods:Fifty nine patients were identified with parotid SCC through the hospital data-base, patients' charts, imaging studies and computerized notes. Results:Fifty of the patients were diagnosed as metastatic SCC from skin primary cancer to parotid lymph nodes; 28% were immunocompromized and 9 patients were diagnosed as primary SCC of the parotid gland, none was immunocompromized. Forty seven patients with metastatic SCC were treated with surgery and post-operative radiotherapy. The rate of neck lymph node metastases was 54%. The median follow up of these patients was 33 months and the 3-year actuarial cause specific survival was 91%. The 3-year actuarial local recurrence free survival (LRFS) and disease free survival rate were 79% and 77% respectively. Positive surgical margin after parotidectomy was the only factor that had statistically significant poor LRFS. Patients with primary parotid SCC had DFS of 100%. Conclusion:The most common site of the primary tumor was a cutaneous SCC of the face. All patients should be considered for facial nerve sparing radical parotidectomy and adjuvant radiotherapy. Neck dissection or elective neck irradiation for ipsilateral neck is recommended due to high occult LN metastasis.

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Parotid and neck metastases from cutaneous squamous cell carcinoma of the head and neck

Cited by 106 publications

References 19 publications

Significance of clinical stage, extent of surgery and outcome in cutaneous squamous cell carcinoma of the head and neck

Significance of clinical stage, extent of surgery and outcome in cutaneous squamous cell carcinoma of the head and neck

Metastatic cutaneous squamous cell carcinoma of the head and neck

Parotid squamous cell carcinoma: Outcome of multidisplinary management

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