Significance of clinical stage, extent of surgery and outcome in cutaneous squamous cell carcinoma of the head and neck

Svetina, Lucija; Lukšić, Ivica

doi:10.1016/j.ijom.2012.10.007

Cited by 21 publications

(28 citation statements)

References 32 publications

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“…Jardim et al 13 and Kosec et al 14 have both recently showed that the presence of PNS is a negative prognostic factor for patient outcomes. Broadly speaking, patients are treated with either combination surgery and radiotherapy, radiation alone or with palliation.…”

Section: Discussionmentioning

confidence: 99%

3T MRI evaluation of large nerve perineural spread of head and neck cancers

et al. 2015

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Targeted 3T MRI is highly accurate in defining the presence and extent of large nerve PNS in head and neck cancers. However, there is still a tendency to undercall the zonal extent due to microscopic, radiologically occult involvement. Superficial large nerve involvement also remains a difficult area of detection for radiologists and should be included as a 'check area' for review. Further research is required to define the role radiation-induced neuritis plays in the presence of false-positive PNS on MRI.

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Section: Discussionmentioning

confidence: 99%

3T MRI evaluation of large nerve perineural spread of head and neck cancers

et al. 2015

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“…5 Confirming previous findings, our study determined that positive margins on prior cSCC excision and perineural involvement are associated with parotid metastasis. 14,16 Identification of parotid involvement may be challenging, and optimal management of head and neck cSCC in the presence of a clinically negative parotid and neck is unclear. 17 Therapeutic options include periodic surveillance, elective nodal dissection, and irradiation.…”

Section: Discussionmentioning

confidence: 99%

Biomarker and Pathologic Predictors of Cutaneous Squamous Cell Carcinoma Aggressiveness

Khandelwal

Egan

et al. 2016

Otolaryngol.--head neck surg.

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“…Other anatomic pathologic criteria of the tumor should be considered, such as depth of invasion, histological differentiation grade, presence of perineural and lymphovascular invasion, because many patients in stages T1 and T2 may develop regional and distal metastases. 3,17 …”

Section: Discussionmentioning

confidence: 99%

Invasive head and neck cutaneous squamous cell carcinoma: clinical and histopathological characteristics, frequency of local recurrence and metastasis

Vasconcelos

Melo

Miot

et al. 2014

An. Bras. Dermatol.

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BACKGROUNDsquamous cell carcinoma is the second most common type of skin malignancy and may evolve to regional lymph node and distant metastases. OBJECTIVEThe objective of this study was to evaluate patients with head and neck cutaneous squamous cell carcinoma to identify its clinical and histopathological characteristics, as well as the frequency of local recurrence and metastasis. METHODSA retrospective cohort of patients with head and neck cutaneous squamous cell carcinoma. Inclusion criteria: histopathological confirmation, follow-up for longer than one year after diagnosis. Exclusion criteria: immunosuppression; lip and oral cavity squamous cell carcinoma; and non-surgical resection of the lesion. We evaluated demographic, clinical and anatomopathologic findings and explored their associations.RESULTSSixty-one patients with 79 tumors and followed by 4.8±3.0 years were selected. The average age was 67.1 years, and 63% of tumors had up to two centimeters. Seven tumors (8.9%) recurred and two of them had positive margins. Recurrence was associated with higher Broders' grade (p<0.01). Two patients (3.3%) had regional lymph node metastases. There were no distant metastases. Seventy tumors were considered to be usual tumors (89.7%), and 68 (87.2%) were classified as Broders' grade 1 and 2. Additionally, 64.1% of tumors had a depth of invasion below four millimeters. Thirteen tumors (16.7%) had positive histological margins. CONCLUSIONSMost patients had good prognosis in the first year of follow-up, confirming that head and neck cutaneous squamous cell carcinoma has a better prognosis than squamous cell carcinoma of other regions such as mucosa, oral cavity, and internal organs.

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Significance of clinical stage, extent of surgery and outcome in cutaneous squamous cell carcinoma of the head and neck

Cited by 21 publications

References 32 publications

3T MRI evaluation of large nerve perineural spread of head and neck cancers

3T MRI evaluation of large nerve perineural spread of head and neck cancers

Biomarker and Pathologic Predictors of Cutaneous Squamous Cell Carcinoma Aggressiveness

Invasive head and neck cutaneous squamous cell carcinoma: clinical and histopathological characteristics, frequency of local recurrence and metastasis

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