Parotid adenoid cystic carcinoma: Retrospective single institute analysis

Abstract

a b s t r a c t a r t i c l e i n f oArticle history: Received 10 February 2017 Available online xxxx Purpose: Adenoid cystic carcinoma (ACC) is a uncommon salivary malignant tumor. Our aim was to review our experience with parotid ACC, to identify clinical-pathological parameters predictive for outcome. Materials and methods: We retrospectively reviewed 228 patients affected by parotid gland carcinomas surgically treated at our Institution. Forty-four ACC were included in this study. Multivariate analysis risk models were built to predict recurrence free probability (RFP), distant recurrence free probability (DRFP), overall survival (OS) and disease free survival (DFS). Results: Twenty-one patients (47.7%) died from ACC and 2.3% for other causes. The 41% presented local-regional recurrence, with a regional-RFP rate of 93%, and the 34% reported distant metastases (DM). The five and ten-year OS rates were 74% and 50%, respectively. Conclusions: Recurrences were mainly influenced by the presence of perineural invasion and nerve paralysis, whilst female gender and age b 50 were predictors for good prognosis.

Sarcomatoid Carcinoma in the Parotid Gland: A Review of 30 Years of Experience

“…Due to the rarity of parotid SaCa, no related literature was available for studying prognostic factors. It was noted that perineural invasion was independently correlated with death, and a similar finding could also be seen in other parotid high‐grade malignancy . However, the common risk factors, such as tumor stage, node status, and radiotherapy, had little effect on the prognosis.…”

“…Shi et al reported that node metastasis and the preoperative House‐Brackmann grade were independent predictors of both RFS and DSS in parotid duct carcinoma. A recent article described that recurrences were mainly influenced by the presence of perineural invasion and nerve paralysis, whereas female gender and age < 50 years were predictors for good prognosis in patients with adenoid cystic carcinoma . Due to the rarity of parotid SaCa, no related literature was available for studying prognostic factors.…”

“…A recent article described that recurrences were mainly influenced by the presence of perineural invasion and nerve paralysis, whereas female gender and age < 50 years were predictors for good prognosis in patients with adenoid cystic carcinoma. 26 Due to the rarity of parotid SaCa, no related literature was available for studying prognostic factors. It was noted that perineural invasion was independently correlated with death, and a similar finding could also be seen in other parotid high-grade malignancy.…”

“…It was noted that perineural invasion was independently correlated with death, and a similar finding could also be seen in other parotid high-grade malignancy. 25,26 However, the common risk factors, such as tumor stage, node status, and radiotherapy, had little effect on the prognosis. It might be mostly attributed by our small sample size.…”

Spinal Metastases from Adenoid Cystic Carcinoma of the Parotid Gland

“…To the Editor: The “Parotid Gland”, out of all the salivary glands, is the one most frequently affected by neoplasms, accounting for approximately 75% in all cases. [ 1 ] These neoplasms are generally benign, with only 25% of them being malignant forms. [ 1 ] The percentage of distant metastases from salivary gland is relatively low, with their occurrence being associated with high-grade tumors.…”