Sarcomatoid Carcinoma in the Parotid Gland: A Review of 30 Years of Experience

Niu, Xingyu

doi:10.1002/lary.27474

Cited by 11 publications

(9 citation statements)

References 24 publications

(57 reference statements)

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“…Accepted survival predictors include high tumour stage, neck lymph node metastasis, perineural invasion, lymphovascular invasion, pathological tumour grade, neutrophil-to-lymphocyte ratio, resection margin, and intraparotid node metastasis [1, 3, 22–24]. Niu et al [23] retrospectively enrolled 35 patients with sarcomatoid carcinoma in the parotid gland, concluding that perineural invasion was the most important predictive factor. Chang et al [24] analysed the oncologic outcome in 98 patients with primary parotid cancer and found that the pathological T stage, resection margin, external parenchymal extension, pathological lymph node status, and maximum standardized uptake value were significantly related to DSS by univariate analysis.…”

Section: Discussionmentioning

confidence: 99%

Oncologic outcome and potential prognostic factors in primary squamous cell carcinoma of the parotid gland

Fang

Liu

2019

BMC Cancer

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s Background Primary parotid squamous cell carcinoma (SCC) is an uncommon tumour, and there is limited data on its prognosis and treatment. The goal of the current study was to analyse the potential prognostic factors and clinical outcomes for this tumour type. Methods Consecutive patients with surgically treated primary parotid SCC were retrospectively enrolled in this study. The primary end point was locoregional control (LRC) and disease-specific survival (DSS), which were calculated by the Kaplan-Meier method. Independent prognostic factors were evaluated by the Cox proportional hazards method. Results In total, 53 patients were included for analysis. Perineural and lymphovascular invasion were observed in 21 and 16 patients, respectively. Intraparotid node (IPN) metastasis was reported in 23 patients with an incidence rate of 43.3%. Twenty-six patients with cN0 disease underwent neck dissection, and pathologic node metastasis was observed in 10 cases. The 5-year LRC and DS S rates were 35 and 49%, respectively. The Cox model was used to report the independence of disease stage and IPN metastasis in predicting LRC and the independence of disease stage and perineural invasion in predicting DSS. Conclusions The prognosis of primary parotid SCC is relatively unfavourable. IPN metastasis significantly decreases disease control, disease stage is the most important prognostic factor, and neck dissection is suggested for patients at any stage.

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Section: Discussionmentioning

confidence: 99%

Oncologic outcome and potential prognostic factors in primary squamous cell carcinoma of the parotid gland

Fang

Liu

2019

BMC Cancer

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“…Sarcomatoid carcinoma in other sites of the head and neck, especially hypopharynx and parotid, has also been associated with a high rate of PNI. 26,27 Due to this strong association and poor outcomes thereafter, we need to consider intensification of adjuvant therapy in the presence of PNI.…”

Section: Discussionmentioning

confidence: 99%

Sarcomatoid variant of squamous carcinoma in recurrent and second primary tumors of the oral cavity

Singh

Sharin

Singhavi

et al. 2020

J Oral Pathology Medicine

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Background: Sarcomatoid variant of oral squamous cell carcinoma (OSCC) is aggressive tumors that frequently recur and metastasize. Our aim was to determine the survival outcomes and factors that predict its incidence in recurrent and second primary tumors (SPT). Methods: We retrospectively analyzed the records of SPT and recurrent OSCC cases with sarcomatoid differentiation. The overall survival (OS) and disease-free survival (DFS) were determined by the Kaplan-Meier method. Logistic regression was used to identify the factors associated with SPT and recurrent sarcomatoid OSCC. Recursive partitioning was performed to classify the sample based on the clinicopathological factors of the index tumor. Results: A total of 82 patients were included in the study with a median survival, calculated from the date of diagnosis of recurrence or SPT, of 6 months (recurrence-2 months, SPT-8 months). The 3-year OS for the recurrence group was 19.9% and for SPT group was 29%. Perineural invasion in the index tumor was significantly associated with sarcomatoid differentiation in the recurrent tumor. At one end of the spectrum of the recursive partitioning were the SPTs that had small index tumor sizes and DOI/thickness less than 14.5 cm (lowest risk), and at the other end were recurrent diseases that had index tumors of advanced T stage (highest risk). Conclusion: Sarcomatoid variant in the recurrent/SPT OSCC infers a poor prognosis. Recurrent disease that had an index tumor with advanced T stage carries the worst outcomes. Perineural invasion in the index tumor can help predict the presence of sarcomatoid carcinoma in the recurrent or SPT.

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“…Because GL tends to be confined to the gastric wall for prolonged periods before tumor spread, its prognosis is better than that of GAC ( 17 ). Previous literature has found that SC in the parotid gland, lung, hypopharynx, liver and pancreas have poor prognoses due to metastasis or recurrence, with a survival period of a few months ( 3 , 22 – 25 ). Similarly, GSC patients also died or developed metastasis or recurrence within a few months, or it was already in the advanced stage at the first diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Computed Tomography Features and Clinicopathological Characteristics of Gastric Sarcomatoid Carcinoma

et al. 2020

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Purpose: Gastric sarcomatoid carcinoma (GSC) is a very rare malignant tumor. The purpose of this study is to describe the clinical, computed tomography (CT), and pathologic features of GSC to increase awareness of this entity. Methods: The CT features and clinical data of five patients with pathologically documented GSC were retrospectively analyzed and compared with the corresponding data of gastric adenocarcinoma and lymphoma. Results: Among the 5 patients, 4 were male, and 1 was female. The median age was 59 years. Of the 5 cases of GSC, 3 were in the gastric fundus and cardia, 1 was in the gastric body, and 1 was in the gastric fundus. The gastric wall had local thickening in 4 cases and mass formation in 1 case, with stenosis and deformation of the adjacent gastric cavity. The long-axis diameter of the lesions ranged from 1.4 to 10.2 cm (mean, 4.97 cm) and was <10 cm in 4 cases and >10 cm in 1 case. The tumor showed predominantly inhomogeneous density, with radiodensity values ranging from 30 to 53 HU. In addition, ulcers with an irregular base and slightly raised borders were observed in 4 of 5 cases. After an injection of contrast material, heterogeneous (n = 4) or homogeneous (n = 1) enhancement was observed. After contrast medium injection, obvious enhancement was seen in 2 cases, and moderate enhancement was seen in 3 cases; the peak tumor signal was observed in the portal phase. Two of the patients demonstrated evidence of lymph node involvement, and in one patient, the boundary between the lesion and the left lobe of the liver was unclear, with low attenuation in the right lobe of the liver with circular enhancement. The remaining two patients showed no evidence of metastasis. Conclusion: Although GSC is extremely rare, it should be considered in the differential diagnosis of gastric adenocarcinoma and lymphoma. CT findings, combined with patient age and sex, can provide support for the diagnosis of GSC. However, the final diagnosis must be confirmed with histopathology.

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Sarcomatoid Carcinoma in the Parotid Gland: A Review of 30 Years of Experience

Abstract: 2b. Laryngoscope, 2018.

Cited by 11 publications

References 24 publications

Oncologic outcome and potential prognostic factors in primary squamous cell carcinoma of the parotid gland

Oncologic outcome and potential prognostic factors in primary squamous cell carcinoma of the parotid gland

Sarcomatoid variant of squamous carcinoma in recurrent and second primary tumors of the oral cavity

Computed Tomography Features and Clinicopathological Characteristics of Gastric Sarcomatoid Carcinoma

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