Parosmia and altered taste in patients recovering from Covid 19

Kelly, Chris

doi:10.1016/j.nutos.2022.11.008

Cited by 10 publications

(21 citation statements)

References 19 publications

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“…Infections with germs or viruses, head trauma, neurological disorders and COVID‐19 are some of the causes. Parosmia is often transient; however, it can occasionally be persistent 36,37 . It is seen that participants with parosmia in our study could not mostly describe the smell of onion, garlic, pepper, lemon, meat, chicken and egg.…”

Section: Discussioncontrasting

confidence: 56%

“…Although the mechanism of smell and taste loss in COVID‐19 disease has not been fully elucidated, there is an integral relationship between smell and taste 11,13,30 . In the literature, it has been found that patients report that bacon and jam taste like soap, meat tastes like rotten meat and coke tastes like perfume and they mostly sense a metallic taste 15,36 . In our study, some participants who experienced ageusia (inability to taste) stated that they tasted sweet, sour, salty and bitter but could not detect their intensity and aroma.…”

Section: Discussionmentioning

confidence: 61%

“…Parosmia is often transient; however, it can occasionally be persistent. 36,37 It is seen that participants with parosmia in our study could not mostly describe the smell of onion, garlic, pepper, lemon, meat, chicken and egg. They stated that they cannot exactly describe the smell of these things, but they used descriptors such as 'rotten, spoilt, odd, like smell of carrion, sickening'.…”

Section: Discussionmentioning

confidence: 61%

“…11,13,30 In the literature, it has been found that patients report that bacon and jam taste like soap, meat tastes like rotten meat and coke tastes like perfume and they mostly sense a metallic taste. 15,36 In our study, some participants who experienced ageusia (inability to taste) stated that they tasted sweet, sour, salty and bitter but could not detect their intensity and aroma. They also stated that they tend to add more salt and sugar because of the decrease in the intensity of the taste.…”

Section: Discussionmentioning

confidence: 65%

“…However, in the literature, olfactory training involving smelling aromatic scents (lemon, rose, clove and eucalyptus) twice a day, for 20 s each, for at least 3 months is recommended 6–8 . Although corticosteroids are recommended in the literature, it is stated that the level of evidence on treatment efficacy is low 7–39 …”

Section: Discussionmentioning

confidence: 99%

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Long‐term smell loss experiences after COVID‐19: A qualitative study

Alkanat,

Arslan

2024

Health Expectations

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ObjectivesSudden smell loss is one of the early symptoms of COVID‐19. Although it is stated that the loss of smell and taste following COVID‐19 improves within a few weeks, there are also cases that do not improve for a long time. The aim of this study is to reveal long‐term smell loss experiences after COVID‐19.MethodsA qualitative approach was adopted. We conducted semistructured interviews with 11 participants who had smell loss for at least 3 months. Interviews were recorded, transcribed and evaluated using a thematic analysis for qualitative data.ResultsNutrition and appetite, personal hygiene, threats to safety and emotional changes were the main themes created by the authors and were the areas where participant expressions focused. The participants used oral/nasal corticosteroid therapy for smell loss and received short‐term olfactory training, but could not find a solution.ConclusionsLong‐term smell loss problems, which were neglected during the pandemic period, should be carefully evaluated due to their negative effects. Understanding and focusing on the negative effects of loss of smell may contribute to the solution of long‐term smell loss problems.Patient and Public ContributionEleven participants who experienced long‐term loss of smell following COVID‐19 contributed to the study. They enriched the study by describing the effects of their experiences. There was no other participation or contribution from the public to the research.

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Section: Discussioncontrasting

confidence: 56%

Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

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Long‐term smell loss experiences after COVID‐19: A qualitative study

Alkanat,

Arslan

2024

Health Expectations

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Long COVID: From olfactory dysfunctions to viral Parkinsonism

Pandey,

Bapat,

Abraham

et al. 2024

World j. otorhinolaryngol.-head neck surg.

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Neurological and psychiatric complications continue to be a public health concern in long coronavirus disease 2019 (COVID‐19). This varies from olfactory dysfunctions such as parosmia to cognitive and emotional challenges. Historically, the surge of neurological disorders followed the viral pandemics, for example, the emergence of Encephalitis Lethargica after the outbreak of Spanish Influenza. During and after COVID‐19 infection, the problems associated with the sense of smell and the reports of affected olfactory and limbic brain areas are leading to a growing concern about the similarity with the symptoms and the pattern of degeneration observed at the onset of Parkinson's disease and Alzheimer's disease. These reports reveal the essentiality of long‐term studies of olfactory and cognitive functions in the post‐COVID era and the experiments using animal models to dissect the neural basis of these complications. In this manuscript, we summarize the research reporting the potential correlation between neurological disorders and viral pandemic outbreaks with a historical perspective. Further, we discuss the studies providing evidence of neurodegeneration due to severe acute respiratory syndrome coronavirus 2 infection by focusing on viral Parkinsonism.

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Infection with COVID-19 promotes the progression of pancreatic cancer through the PI3K-AKT signaling pathway

Zhang,

Chen,

Liu

et al. 2023

Discov Onc

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Objective To investigate the effect of COVID-19 infection on pancreatic cancer. Methods Based on the mRNA-Seq data of COVID-19 patients and pancreatic cancer (PC) patients in the GEO database, we used a support vector machine (SVM), LASSO-Cox regression analysis and random forest tree (RF) to screen the common signature genes of the two diseases and further investigate their effects and functional characteristics on PC, respectively. The above procedures were performed in R software. Results The proteins COL10A1/FAP/FN1 were found to be common signature genes for COVID-19 and PC, were significantly up-regulated in both diseases and showed good diagnostic efficacy for PC. The risk model based on COL10A1/FAP/FN1 showed good PC risk prediction ability and clinical application potential. Tumor typing based on COL10A1/FAP/FN1 expression levels effectively classified PC into different subtypes and showed significant differences between the two subtypes in terms of survival prognosis, immune levels, immune checkpoint expression levels, mutation status of common tumor mutation sites, and drug sensitivity analysis. While pathway analysis also revealed that FN1 as an extracellular matrix component may be involved in the biological process of PC by regulating the PI3K-AKT signaling axis. Conclusion The upregulated expression of COL10A1/FAP/FN1, the characteristic genes of COVID-19, are potential diagnostic targets for PC, and the upregulated expression of FN1 may promote the progression of PC by activating the PI3K-AKT signaling pathway. The COL10A1/FAP/FN1-based typing provides a new typing approach for PC, and also provides a good reference and idea for the refinement of PC treatment and subsequent clinical research.

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Parosmia and altered taste in patients recovering from Covid 19

Cited by 10 publications

References 19 publications

Long‐term smell loss experiences after COVID‐19: A qualitative study

Long‐term smell loss experiences after COVID‐19: A qualitative study

Long COVID: From olfactory dysfunctions to viral Parkinsonism

Infection with COVID-19 promotes the progression of pancreatic cancer through the PI3K-AKT signaling pathway

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