Parkinsonism and Epilepsy

Frigyesi, Tamas L.

doi:10.1007/978-1-4684-2511-6_4

Cited by 4 publications

(1 citation statement)

References 36 publications

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“…The paradoxical anticonvulsant activity of BMI in the striatum and the unusual potency of this action argue for a physioloscal role of striatal GABA in modulating the seizure threshold. It may also rovide an explanadevelop Parkinson's disease stop seizures (McPherson, 1970;Yakovlev, 19281, and that parkinsonian patients do not suffer from epilepsy (Frigyesi, 1977;McPherson, 1970). In the striata of parkinsonian patients, apart from a decrease of the dopamine-synthesizing enzyme tyrosine hydroxylase and dopamine concentration, both the activity of the GABA synthesizing enzyme L-glutamate decarboxylase and the GABA concentration are tion for the observation that epi P eptic patients who activity in the hippocampus is replaced with high-voltage fast activity and spiking within 1-2 min after injection of BMI into the EP.…”

Section: Administration Of Pilocarpine (380 Mgikg) Dark Circles Reprmentioning

confidence: 99%

Paradoxical anticonvulsant acitivity of the γhyphen;Aminobutyrate antagonist bicuculline methiodide in the rat striatum

Turski

Diedrichs

Klockgether

et al. 1991

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Bicuculline methiodide (BMI), a gamma-aminobutyrate (GABA) antagonist, is a powerful convulsant agent when injected into the cerebral ventricles, amygdala, hippocampus, thalamus, neocortex, and deep prepiriform cortex in rats. In contrast, bilateral microinjection of BMI into the rat striatum confers protection against seizures induced by the cholinergic agonist pilocarpine (380 mg/kg, i.p.), with an ED50 of 94 fmol (range 45-195 fmol). No topographical variation in the anticonvulsant action of BMI was detected throughout rostrocaudal and dorsoventral aspects of the striatum. The anticonvulsant action of BMI in the striatum was reversed by coadministration of the GABA agonist muscimol or by blocking GABA-mediated inhibition in either the substantia nigra pars reticulata or in the entopeduncular nucleus. The results show that blockade of GABA-mediated inhibition in the striatum has a powerful anticonvulsant effect in the pilocarpine model, suggesting that GABAergic transmission in the striatum modulates the seizure propagation in the forebrain.

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Section: Administration Of Pilocarpine (380 Mgikg) Dark Circles Reprmentioning

confidence: 99%

Paradoxical anticonvulsant acitivity of the γhyphen;Aminobutyrate antagonist bicuculline methiodide in the rat striatum

Turski

Diedrichs

Klockgether

et al. 1991

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Augmentation of thalamo — Motor cortico — Cerebellar epileptogenesis by taurine and its antagonism by diphenylhydantoin

Frigyesi

Lombardini

1979

Life Sciences

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Progressive Supranuclear Palsy

Jankovic

Rohaidy

1987

Can. J. Neurol. Sci.

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ABSTRACT:Progressive supranuclear palsy (PSP) was first recognized as a distinct morbid entity by Richardson, Steele and Olszewski a quarter century ago. Subsequent experience has confirmed and extended their original observations. PSP has become familiar as a chronic progressive disorder with extrapyramidal rigidity, bradykinesia, gait impairment, bulbar palsy, dementia and a characteristic supranuclear ophthalmoplegia. It is an important cause of parkinsonism. Its etiology remains obscure. Familial concentrations have not been observed.Some cases exhibit no oculomotor dysfunction. Dementia is usually mild. Recent neuropsychological studies have defined features consistent with frontal lobe cortical dysfunction. Seizures and paroxysmal EEG activity may occur.CT and MRI scans show midbrain atrophy early and later atrophy of the pontine and midbrain tegmentum and the frontal and temporal lobes. PET scans have shown frontal hypometabolism and loss of striatal D-2 dopamine receptors. Postmortem studies have documented involvment of both dopaminergic and cholinergic systems. Treatment remains palliative and unsatisfactory.

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Parkinsonism and Epilepsy

Cited by 4 publications

References 36 publications

Paradoxical anticonvulsant acitivity of the γhyphen;Aminobutyrate antagonist bicuculline methiodide in the rat striatum

Paradoxical anticonvulsant acitivity of the γhyphen;Aminobutyrate antagonist bicuculline methiodide in the rat striatum

Augmentation of thalamo — Motor cortico — Cerebellar epileptogenesis by taurine and its antagonism by diphenylhydantoin

Progressive Supranuclear Palsy

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