Augmentation of thalamo — Motor cortico — Cerebellar epileptogenesis by taurine and its antagonism by diphenylhydantoin

Frigyesi, Tamas L.; Lombardini, John B.

doi:10.1016/0024-3205(79)90144-9

Cited by 8 publications

(1 citation statement)

References 16 publications

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“…Although mechanisms of taurine action in epilepsy are not fully understood, it can reduce seizure episodes as a neuroprotector (Barbeau, 1973(Barbeau, , 1975Izumi et al, 1975;Durelli et al, 1976Durelli et al, , 1977van Gelder et al, 1977;Frigyesi and Lombardini, 1979). For example, mice pretreated with 43 mg/kg taurine show longer onset of tonic seizures after kainate administration, also reducing tonic-clonic convulsions, mortality rate, and neuronal cell death in the hippocampus (El Idrissi et al, 2003).…”

Section: Taurine and Epilepsymentioning

confidence: 99%

Understanding taurine CNS activity using alternative zebrafish models

Mezzomo

Fontana

Kalueff

et al. 2018

Neuroscience & Biobehavioral Reviews

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Taurine is a highly abundant "amino acid" in the brain. Although the potential neuroactive role of taurine in vertebrates has long been recognized, the underlying molecular mechanisms related to its pleiotropic effects in the brain remain poorly understood. Due to the genetic tractability, rich behavioral repertoire, neurochemical conservation, and small size, the zebrafish (Danio rerio) has emerged as a powerful candidate for neuropsychopharmacology investigation and in vivo drug screening. Here, we summarize the main physiological roles of taurine in mammals, including neuromodulation, osmoregulation, membrane stabilization, and antioxidant action. In this context, we also highlight how zebrafish models of brain disorders may present interesting approaches to assess molecular mechanisms underlying positive effects of taurine in the brain. Finally, we outline recent advances in zebrafish drug screening that significantly improve neuropsychiatric translational research and small molecule screens.

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