Parkinson’s disease and pesticides: A meta-analysis of disease connection and genetic alterations

Ahmed, Hussien; Abushouk, Abdelrahman Ibrahim; Gabr, Mohamed; Negida, Ahmed; Abdel-Daim, Mohamed M.

doi:10.1016/j.biopha.2017.03.100

Cited by 87 publications

(48 citation statements)

References 102 publications

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“…Many epidemiological studies and meta‐analyses have found associations between pesticide exposure and risk of PD, and some evidence of a dose–response relationship exists . In the past decade, there have been a number of studies that support a causal role of pesticides in PD risk.…”

Section: The Past 10 Yearsmentioning

confidence: 99%

Environment, lifestyle, and Parkinson's disease: Implications for prevention in the next decade

2019

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There is evidence from observational studies for a role of a number of environmental exposures and lifestyle habits in modulating the risk for Parkinson's disease. Environmental and lifestyle associations, if causal, represent opportunities for Parkinson's disease prevention or disease modification at individual and population levels. In the past decade, additional evidence has been published that improves causal inference and/or enhances our understanding of the complexity of these associations. A number of gene–environment interactions have been elucidated, and our understanding of the roles of physical activity, pesticide and other chemical exposures, dietary habits, emotional stress, head injury, and smoking has been refined. In the next decade, better techniques will help us to close the gaps in our knowledge, including taking into account Parkinson's disease heterogeneity and gene and risk factor interactions in observational studies. To do this, larger datasets, global consortia, genomewide environment interaction studies, prospective studies throughout the lifespan, and improvements in the methodology of clinical trials of physical activity will be key. Despite the caveats of observational studies, a number of low‐risk and potentially high‐yield recommendations for lifestyle modification could be made to minimize the individual and societal burdens of Parkinson's disease, including dietary modifications, increasing physical activity, and head injury avoidance. Furthermore, a reduction in pesticide use could have a major impact on global health related to and beyond Parkinson's disease. Given the increasing prevalence of this disorder, formulating and promoting these recommendations should be a high priority. © 2019 International Parkinson and Movement Disorder Society

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Section: The Past 10 Yearsmentioning

confidence: 99%

Environment, lifestyle, and Parkinson's disease: Implications for prevention in the next decade

2019

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“…However, it is well known that sporadic PD risk is determined by the complex interplay of genetic and environmental risk factors. Several studies have discussed the environmental risk factors of PD [4]. Factors such as head injury, pesticide exposure, and anxiety diary product have a positive association with PD, while smoking and coffee and alcohol consumption have an inverse relation with PD [5].…”

Section: Introductionmentioning

confidence: 99%

Clinical Features and Risk Factors of Parkinson’s Disease in a Population of Khyber Pakhtunkhwa, Pakistan: A Case-Control Study

Tufail¹

2019

Neurodegener Dis

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Background: Parkinson’s disease (PD) is one of the most common neurological disorders that mostly affect aged individuals. The common symptoms of PD are rest tremor, bradykinesia, and rigidity. Objectives: The present study was devised to find out the clinical features and risk factors associated with PD in a population of Khyber Pakhtunkhwa. Methods:A total of 600 PD patients and 1,200 control individuals took part in this study. The participants filled out a standard questionnaire. Results: This study found a significant association between PD and exposure to pesticides (p < 0.0001) and doing work on farms (p < 0.0001). The use of aldrin was significantly associated with PD (p < 0.0001). Furthermore, we also found that PD status was associated with individuals who have a history of depression, hypertension, head injury, and Alzheimer’s disease. This study also showed that the PD rate was lower in those who were using tobacco products. Conclusion: In this case-control study, we revealed some environmental and medical conditions that are linked with PD. To control the disease, we must minimize exposure to pesticides, and the government and scientific community should play their role.

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“…In patients with major depression, a significant association between a loss‐of‐function MDR1 (ABCB1) polymorphism and postural hypotension induced by nortriptyline, an MDR1 substrate, has been observed . In addition, MDR1 and BCRP also transport neurotoxic endogenous chemicals, including amyloid‐β as well as exogenous pesticides . Therefore, understanding the mechanisms by which BBB transporters are regulated is important for neuronal protection and drug efficacy in the brain.…”

Section: Introductionmentioning

confidence: 99%

Brain region‐specific regulation of histone acetylation and efflux transporters in mice

You

Shin

Mosaad

et al. 2019

J Biochem & Molecular Tox

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Multidrug resistance protein 1 (MDR1) and breast cancer resistance protein (BCRP) protect the brain by restricting the passage of chemicals across the blood-brain barrier. Prior studies have demonstrated the epigenetic regulation of MDR1 and BCRP in cancer cells treated with histone deacetylase (HDAC) inhibitors that enhance histone acetylation and gene transcription. In the present study, we tested the in vivo effects of two HDAC inhibitors, valproic acid (VPA; 400 mg/kg) and apicidin (5 mg/kg), on Mdr1 and Bcrp transporter expression in brain regions of adult male mice injected intraperitoneally daily for 7 days. VPA increased Mdr1 protein expression in the striatum (70%) and Bcrp protein in the midbrain (30%). Apicidin enhanced striatal Mdr1 protein (30%) and hippocampal Bcrp protein (20%).Transporter induction correlated with increased histone H3 acetylation in discrete brain regions. In conclusion, HDAC inhibitors upregulate transporter proteins in vivo, which may be important in regulating regional xenobiotic disposition within the brain.

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Parkinson’s disease and pesticides: A meta-analysis of disease connection and genetic alterations

Cited by 87 publications

References 102 publications

Environment, lifestyle, and Parkinson's disease: Implications for prevention in the next decade

Environment, lifestyle, and Parkinson's disease: Implications for prevention in the next decade

Clinical Features and Risk Factors of Parkinson’s Disease in a Population of Khyber Pakhtunkhwa, Pakistan: A Case-Control Study

Brain region‐specific regulation of histone acetylation and efflux transporters in mice

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