Paresthesias and Sensory Neuropathy Due to 1,1,1-Trichloroethane

Ra, House; Gm, Liss; Mc, Wills; Dl, Holness

doi:10.1097/00043764-199602000-00002

Cited by 11 publications

(9 citation statements)

References 2 publications

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“…A subsequent case of peripheral sensory neuropathy in a woman who had daily exposure to 1,1,1-trichloroethane used as a degreasing agent, involved perioral tingling, and a burning sensation on her tongue, accompanied by discomfort in her hands and feet [House et al, 1994]. We also described a male engineer who complained of bilateral numbness of his hands and feet and tingling of his face, which developed a few days after he had used a degreasing agent to clean car parts [House et al, 1996].…”

Section: To the Editormentioning

confidence: 91%

Cranial neuropathy associated with chlorinated solvents. Re: Facial nerve palsy after acute exposure to dichloromethane

Liss

House

Wills

2006

American J Industrial Med

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Section: To the Editormentioning

confidence: 91%

Cranial neuropathy associated with chlorinated solvents. Re: Facial nerve palsy after acute exposure to dichloromethane

Liss

House

Wills

2006

American J Industrial Med

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“…4b). Discussion The exposure to environmental toxic chemicals can cause several detrimental effects in biological cell systems (Topham, 1980;House et al, 1996;Snyder and Andrews, 1996;Griffin et al, 2000;Wang et al, 2007Wang et al, , 2013Al-Griw et al, 2015a,b,c). TCE, a widely used industrial agent and a ubiquitous environmental contaminant, is non-carcinogenic (group 3) because there is inadequate evidence for carcinogenicity in both human and animals according to EPA and National Toxicology Program (NTP) technical report (NTP, 2000;EPA, 2007).…”

Section: Tce Induces Vascular and Degenerative Changes In Hepatic Arcmentioning

confidence: 99%

Cellular and molecular etiology of hepatocyte injury in a murine model of environmentally induced liver abnormality

Al-Griw¹,

Alghazeer²,

Al-Azreg³

et al. 2016

Open Vet J.

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Exposures to a wide variety of environmental substances are negatively associated with many biological cell systems both in humans and rodents. Trichloroethane (TCE), a ubiquitous environmental toxicant, is used in large quantities as a dissolvent, metal degreaser, chemical intermediate, and component of consumer products. This increases the likelihood of human exposure to these compounds through dermal, inhalation and oral routes. The present in vivo study was aimed to investigate the possible cellular and molecular etiology of liver abnormality induced by early exposure to TCE using a murine model. The results showed a significant increase in liver weight. Histopathological examination revealed a TCE-induced hepatotoxicity which appeared as heavily congested central vein and blood sinusoids as well as leukocytic infiltration. Mitotic figures and apoptotic changes such as chromatin condensation and nuclear fragments were also identified. Cell death analysis demonstrates hepatocellular apoptosis was evident in the treated mice compared to control. TCE was also found to induce oxidative stress as indicated by an increase in the levels of lipid peroxidation, an oxidative stress marker. There was also a significant decrease in the DNA content of the hepatocytes of the treated groups compared to control. Agarose gel electrophoresis also provided further biochemical evidence of apoptosis by showing internucleosomal DNA fragmentation in the liver cells, indicating oxidative stress as the cause of DNA damage. These results suggest the need for a complete risk assessment of any new chemical prior to its arrival into the consumer market.

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“…Following acute exposure to TCA, symptoms can include light-headedness, headache, incoordination, and drowsiness. Continued exposure can lead to loss of consciousness, coma, and death [Gresham and Treip, 1983;House et al, 1996]. TCA can induce cardiac arrhythmia with sudden death [Ranson and Berry, 1986].…”

Section: Trichloroethanementioning

confidence: 99%

“…Chronic exposure to TCA has been reported to cause permanent toxic encephalopathy and sensory neuropathy, with axonopathy and secondary myelinopathy, in degreasing workers [Liss, 1988]. Symptoms may be mild, with headache, anxiety, depression, insomnia, and digestive complaints [Kelafant et al, 1994;House et al, 1996]. Neurobehavioral testing has demonstrated impairment of attention, concentration, and short-term memory among workers with a history of recurrent dizziness and nausea following exposures to TCA [Kelafant et al, 1994].…”

Section: Trichloroethanementioning

confidence: 99%

The diagnosis and management of solvent-related disorders

J¹,

Levin

2000

Am J Ind Med

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Millions of workers in the United States are recurrently exposed to solvents throughout their working lives. Members of this class of compounds share the ability to dissolve waxes, fats, and oils as their common characteristic. This review offers the health practitioner a practical approach to the diagnosis, management, and prevention of solvent‐related disorders that result from exposures to these compounds in the workplace. A description of commonly used solvents is provided, along with a brief review of the literature that documents their acute and chronic effects on health. Am. J. Ind. Med. 37:44–61, 2000. © 2000 Wiley‐Liss, Inc.

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Paresthesias and Sensory Neuropathy Due to 1,1,1-Trichloroethane

Cited by 11 publications

References 2 publications

Cranial neuropathy associated with chlorinated solvents. Re: Facial nerve palsy after acute exposure to dichloromethane

Cranial neuropathy associated with chlorinated solvents. Re: Facial nerve palsy after acute exposure to dichloromethane

Cellular and molecular etiology of hepatocyte injury in a murine model of environmentally induced liver abnormality

The diagnosis and management of solvent-related disorders

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