Parenteral amino acid intakes: possible influences of higher intakes on growth and bone status in preterm infants

Abstract

Early higher AA intakes improved growth without short-term AA intolerance. Nutritional parameters could influence bone growth. LLL was the anthropometric parameter that best correlated to bone status.

Low- versus High-Dose and Early versus Late Parenteral Amino-Acid Administration in Very-Low-Birth-Weight Infants: A Systematic Review and Meta-Analysis

“…Vlaardingerbroek et al [13], Clark et al [16], and Blanco et al [33,34,35] reported mean weight gain for the first 28 days, Burattini et al [24] compared mean weight gain at 36 weeks postmenstrual age (PMA), and Bellagamba et al [23] reported mean weight gain rates from birth and regain of BW to 1,800 g (54 days in both groups). Scattolin et al [26] also reported growth rates, but only for the 2nd and 3rd week of life separately and was, therefore, not included in the meta-analysis. They described a higher growth rate in the intervention group that became significant in the 3rd week of life (18.76 [SD 6.83] vs. 14.70 [SD 8.99] g/kg/day, p < 0.01).…”

“…Meta-analysis was not possible due to a lack of consistency in the timeline, but none of the individual studies found a significant difference in head growth rate between groups. Mean HC per group at 36 weeks PMA was described in 5 studies [23,24,25,26,27]. All 5 studies indicated no difference in HC at birth.…”

“…Eight studies compared low- versus high-dose amino-acid supplementation [13,16,23,24,25,26,27,28], 5 studies compared early versus late supplementation [12,29,30,31,32], and 3 studied both [16,33,34,35]. Three studies, from Blanco et al [33,34,35], were based on the same study population and were, therefore, seen as one.…”

Dietary proteins and IGF I levels in preterm infants: determinants of growth, body composition, and neurodevelopment

“…Whether this trend persists into childhood is not known. Using bone transmission time, Scattolin et al found protein intake to positively correlate with bone mineral status at 36 wk postmenstrual age (60). However, Fewtrell was unable to correlate protein intake in infancy with peak bone mass or bone turnover in young adulthood (36).…”

“…These studies report improved absolute and standardized measures of weight, length and head circumference as well as an increased growth velocity. No intolerance of high-protein diets has been reported (52,60) and glycaemic control might actually be improved with a high protein intake (53,54). However, protein intake in the neonatal period will not necessarily have an impact on growth indices in childhood (59).…”