Dietary proteins and IGF I levels in preterm infants: determinants of growth, body composition, and neurodevelopment

Yumani, Dana F. J.; Lafeber, Harrie N.; Weissenbruch, Mirjam M. van

doi:10.1038/pr.2014.172

Cited by 27 publications

(29 citation statements)

References 81 publications

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“…Postnatal growth deficits are common among preterm infants (7), and at term-corrected age, preterm infants may show increased body fat proportion, relative to term infants, indicating nutritional and metabolic imbalances (29). These effects may relate to low levels of IGF-1 following preterm birth (24,25,53) that have also been associated with a smaller brain volume at term-corrected age (25) and a higher risk of suboptimal neurodevelopment at 2 yr old (26). Until now, a clinically relevant animal model of preterm birth that allows detailed study of organ development and physiology beyond the immediate postnatal period has not been available.…”

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confidence: 99%

Delayed growth, motor function and learning in preterm pigs during early postnatal life

Andersen¹,

Sangild

Munch³

et al. 2016

American Journal of Physiology-Regulatory, Integrative and Comp

117

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Preterm birth interrupts normal fetal growth with consequences for postnatal growth and organ development. In preterm infants, many physiological deficits adapt and disappear with advancing postnatal age, but some may persist into childhood. We hypothesized that preterm birth would induce impaired organ growth and function during the first postnatal week in pigs, while motor abilities and behavioral characteristics would show more persistent developmental delay. Cesarean-delivered preterm (n = 112, 90% gestation) or term (n = 56, 100% gestation) piglets were reared under identical conditions and euthanized for blood and organ collection on postnatal days 0, 5, or 26. Body weight gain remained lower in preterm vs. term pigs up to day 26 (25.5 ± 1.5 vs. 31.0 ± 0.5 g·kg(-1)·day(-1), P < 0.01) when relative weights were higher for brain and kidneys and reduced for liver and spleen. Neonatal preterm pigs had reduced values for blood pH, Po2, glucose, lactate, hematocrit, and cortisol, but at day 26, most values were normalized, although plasma serotonin and IGF 1 levels remained reduced. Preterm pigs showed delayed neonatal arousal and impaired physical activity, coordination, exploration, and learning, relative to term pigs (all P < 0.05). Supplementation of parenteral nutrition during the first 5 days with an enteral milk diet did not affect later outcomes. In preterm pigs, many physiological characteristics of immaturity disappeared by 4 wk, while some neurodevelopmental deficits remained. The preterm pig is a relevant animal model to study early dietary and pharmacological interventions that support postnatal maturation and neurodevelopment in preterm infants.

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confidence: 99%

Delayed growth, motor function and learning in preterm pigs during early postnatal life

Andersen¹,

Sangild

Munch³

et al. 2016

American Journal of Physiology-Regulatory, Integrative and Comp

117

View full text Add to dashboard Cite

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“…A recent review pointed out that IGF-1 concentrations correlate differently with growth before and after term-equivalent age in preterm infants (22). Hansen-Pupp et al (24) reported that IGF-1 concentrations correlated positively with weight gain at an early postnatal age in preterm infants.…”

Section: Discussionmentioning

confidence: 99%

“…Van de Lagemaat et al (25) reported that both preceding length and weight growth were positively associated with IGF-1 at term, 3 and 6 months CA. After term age, studies show contradictive results in relation to IGF-1 concentrations and correlations with subsequent growth (22). …”

Section: Discussionmentioning

confidence: 99%

“…Insulin-like growth factor-1 (IGF-1) promotes cell growth, inhibits apoptosis, and stimulates glucose uptake and protein synthesis (22). This polypeptide is related to nutritional status (22) and associated with postnatal growth in term and preterm infants (23–25).…”

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confidence: 99%

“…This polypeptide is related to nutritional status (22) and associated with postnatal growth in term and preterm infants (23–25). …”

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Enhanced nutrition improves growth and increases blood adiponectin concentrations in very low birth weight infants

Blakstad

Moltu

Nakstad

et al. 2016

Food & Nutrition Research

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BackgroundAdequate nutrient supply is essential for optimal postnatal growth in very low birth weight (VLBW, birth weight<1,500 g) infants. Early growth may influence the risk of metabolic syndrome later in life.ObjectiveTo evaluate growth and blood metabolic markers (adiponectin, leptin, and insulin-like growth factor-1 (IGF-1)) in VLBW infants participating in a randomized nutritional intervention study.DesignFifty VLBW infants were randomized to an enhanced nutrient supply or a standard nutrient supply. Thirty-seven infants were evaluated with growth measurements until 2 years corrected age (CA). Metabolic markers were measured at birth and 5 months CA.ResultsWeight gain and head growth were different in the two groups from birth to 2 years CA (weight gain: pinteraction=0.006; head growth: pinteraction=0.002). The intervention group improved their growth z-scores after birth, whereas the control group had a pronounced decline, followed by an increase and caught up with the intervention group after discharge. At 5 months CA, adiponectin concentrations were higher in the intervention group and correlated with weight gain before term (r=0.35) and nutrient supply (0.35≤r≤0.45). Leptin concentrations correlated with weight gain after term and IGF-1 concentrations with length growth before and after term and head growth after term (0.36≤r≤0.53).ConclusionEnhanced nutrient supply improved early postnatal growth and may have prevented rapid catch-up growth later in infancy. Adiponectin concentration at 5 months CA was higher in the intervention group and correlated positively with early weight gain and nutrient supply. Early nutrition and growth may affect metabolic markers in infancy.Clinical Trial Registration (ClinicalTrials.gov) no.: NCT01103219

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Polar Lipids Supplementation Enhances Basal Excitatory Synaptic Transmission in Primary Cortical Neuron

Yeo,

Tam,

et al. 2024

Molecular Nutrition Food Res

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ScopePolar lipids, such as gangliosides and phospholipids, are fundamental structural components that play critical roles in the development and maturation of neurons in the brain. Recent evidence has demonstrated that dietary intakes of polar lipids in early life are associated with improved cognitive outcomes during infancy and adolescence. However, the specific mechanisms through which these lipids impact cognition remain unclear.Methods and resultsThis study examines the direct physiological impact of polar lipid supplementation, in the form of buttermilk powder, on primary cortical neuron growth and maturation. The changes are measured with postsynaptic current response recordings, immunohistochemical examination of functional synapse localization and numbers, and the biochemical quantification of receptors responsible for neuronal synaptic neurotransmission. Chronic exposure to polar lipids increases primary mouse cortical neuron basal excitatory synapse response strength attributed to enhanced dendritic complexity and an altered expression of the excitatory α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptor subunit 2 (GluR2).ConclusionThe present finding suggests that dietary polar lipids improve human cognition through an enhancement of neuronal maturation and/or function.

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Dietary proteins and IGF I levels in preterm infants: determinants of growth, body composition, and neurodevelopment

Cited by 27 publications

References 81 publications

Delayed growth, motor function and learning in preterm pigs during early postnatal life

Delayed growth, motor function and learning in preterm pigs during early postnatal life

Enhanced nutrition improves growth and increases blood adiponectin concentrations in very low birth weight infants

Polar Lipids Supplementation Enhances Basal Excitatory Synaptic Transmission in Primary Cortical Neuron

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