Parental psychopathology in families of children with attention‐deficit/hyperactivity disorder and exposed to maternal smoking during pregnancy

Sengupta, Sarojini M.; Fortier, Marie-Ève; Thakur, Geeta; Bhat, Venkat; Grizenko, Natalie; Joober, Ridha

doi:10.1111/jcpp.12286

Cited by 11 publications

(4 citation statements)

References 38 publications

(67 reference statements)

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“…Furthermore, there was a dose-response relationship between the average number of cigarettes smoked per day during pregnancy and verbal IQ and other aspects of neurocognitive functioning. The authors later extended these findings to show that mothers and fathers of children with ADHD who were exposed to smoking during pregnancy (n=168) compared to those who were not (n=346) presented with a much higher burden of mental health difficulties including increased frequency of anti-social personality disorder, substance use disorders, and major depressive disorder [21]. In contrast, Biederman and colleagues [17] did not uncover any differences in the clinical characteristics of children with ADHD who were and were not exposed to prenatal smoking but this finding is also at odds with earlier studies in the area [22][23][24].…”

Section: Recent Findingsmentioning

confidence: 99%

Prenatal Risk Factors and the Etiology of ADHD—Review of Existing Evidence

Sciberras

Mulraney

Silva

et al. 2017

Curr Psychiatry Rep

186

139

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While it is well accepted that attention-deficit/hyperactivity disorder (ADHD) is a highly heritable disorder, not all of the risk is genetic. It is estimated that between 10 and 40% of the variance associated with ADHD is likely to be accounted for by environmental factors. There is considerable interest in the role that the prenatal environment might play in the development of ADHD with previous reviews concluding that despite demonstration of associations between prenatal risk factors (e.g. prematurity, maternal smoking during pregnancy) and ADHD, there remains insufficient evidence to support a definite causal relationship. This article provides an update of research investigating the relationship between prenatal risk factors and ADHD published over the past 3 years. Recently, several epidemiological and data linkage studies have made substantial contributions to our understanding of this relationship. In particular, these studies have started to account for some of the genetic and familial confounds that, when taken into account, throw several established findings into doubt. None of the proposed prenatal risk factors can be confirmed as causal for ADHD, and the stronger the study design, the less likely it is to support an association. We need a new benchmark for studies investigating the etiology of ADHD whereby there is an expectation not only that data will be collected prospectively but also that the design allows the broad range of genetic and familial factors to be accounted for.

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Section: Recent Findingsmentioning

confidence: 99%

Prenatal Risk Factors and the Etiology of ADHD—Review of Existing Evidence

Sciberras

Mulraney

Silva

et al. 2017

Curr Psychiatry Rep

186

139

View full text Add to dashboard Cite

show abstract

“…The rapid rise of ADHD cannot be attributed to genetic mutations. Indeed, multiple social and environmental risk factors have been associated with the development of ADHD, including family-related factors [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ], maternal obesity [ 16 , 17 ], maternal smoking [ 8 , 18 , 19 , 20 ], maternal drinking [ 8 , 21 ], low birthweight and preterm birth [ 22 ], exposure to organophosphates [ 23 ], polychlorinated biphenyls [ 24 , 25 ], and lead exposure [ 24 , 26 , 27 , 28 , 29 ]. These findings underscore the role of environmental factors in the etiology of ADHD, and the need to explore other important yet unknown risk factors for ADHD [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

Maternal Biomarkers of Acetaminophen Use and Offspring Attention Deficit Hyperactivity Disorder

Riley

Lee

et al. 2018

Brain Sciences

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Previous studies have suggested a positive association between self-reported maternal acetaminophen use during pregnancy and risk of attention deficit hyperactivity disorder (ADHD) in offspring. We sought to examine the prospective association between maternal plasma biomarkers of acetaminophen intake and ADHD diagnosis in the offspring. This report analyzed 1180 children enrolled at birth and followed prospectively as part of the Boston Birth Cohort, including 188 with ADHD diagnosis based on electronic medical record review. Maternal biomarkers of acetaminophen intake were measured in plasma samples obtained within 1–3 days postpartum. Odds ratios for having ADHD diagnosis or other developmental disorders were estimated using multinomial logistic regression models, adjusting for pertinent covariables. Compared to neurotypical children, we observed significant positive dose-responsive associations with ADHD diagnosis for each maternal acetaminophen biomarker. These dose–responsive associations persisted after adjusting for indication of acetaminophen use and other pertinent covariates; and were specific to ADHD, rather than other neurodevelopmental disorders. In the stratified analyses, differential point estimates of the associations were observed across some strata of covariates. However, these differences were not statistically significant. Maternal acetaminophen biomarkers were specifically associated with increased risk of ADHD diagnosis in offspring. Additional clinical and mechanistic investigations are warranted.

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“…Their results are disorder specific but have also some similarities. For example, parents were significantly more likely to have ADHD, Tic disorder as well as antisocial personality disorder, and problems with alcohol and drug abuse [ 19 , 20 ]. Parental psychopathology is also described when subsyndromal problems are present in children.…”

Section: Discussionmentioning

confidence: 99%

Lifetime Prevalence of Psychiatric Disorders among Parents of Children with Bipolar I Disorder: Parental Difference

Amiri

Ghoreishizadeh

Alavizadeh

et al. 2014

The Scientific World Journal

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Background. Evaluation of family system is an important area in the context of child and adolescent mental health. This study aimed to estimate psychiatric disorders in parents of children and adolescents with bipolar I disorder (BID). Methods and Materials. In this cross-sectional study, during 2012-2013, all of the children and adolescents diagnosed with BID based on Kiddie Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version were included. All of the parents (both mother and father) were evaluated by Structured Clinical Interview for DSM-IV-TR. Statistical Analysis. Prevalence rates are reported and independent-sample t-test and chi-square test were used when appropriate. Results. A total of 108 families were interviewed. 25% of mothers and 33% of fathers met the criteria for at least one psychiatric disorder, with major depressive disorder, BMD, and cluster B personality disorder being more prevalent. Fathers were more likely to receive a dual psychiatric diagnosis. Cluster B personality disorder and substance dependence were more prevalent among fathers while major depressive disorder was more prevalent among mothers. Conclusion. This study confirmed a higher prevalence of psychiatric disorders in parents of children with BID and emphasizes parental evolution.

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Parental psychopathology in families of children with attention‐deficit/hyperactivity disorder and exposed to maternal smoking during pregnancy

Cited by 11 publications

References 38 publications

Prenatal Risk Factors and the Etiology of ADHD—Review of Existing Evidence

Prenatal Risk Factors and the Etiology of ADHD—Review of Existing Evidence

Maternal Biomarkers of Acetaminophen Use and Offspring Attention Deficit Hyperactivity Disorder

Lifetime Prevalence of Psychiatric Disorders among Parents of Children with Bipolar I Disorder: Parental Difference

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