Parental consanguinity and family history of coronary artery disease strongly predict early stenosis

Youhanna, Sonia; Platt, Daniel E.; Rebeiz, Abdallah; Lauridsen, Michael; Deeb, Mary; Nasrallah, Antoine; Alam, Samir; Puzantian, Houry; Kabbani, Samer; Ghoul, M.; Zreik, Tony G.; Bayeh, Hamid el; Abchee, Antoine; Zalloua, Pierre

doi:10.1016/j.atherosclerosis.2010.07.013

Cited by 20 publications

(17 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A total of 5,347 Lebanese patients undergoing cardiac catheterization were sequentially enrolled for the FGENTCARD study (Youhanna et al 2010) as part of a multi-center cross-sectional study conducted at the Lebanese American University, the Rafic Hariri University Hospital and the “Centre Hospitalier du Nord” Lebanon, between May 2007 and June 2010. The Institutional Review Board at the Lebanese American University approved the study protocol and all subjects gave informed consent before their enrollment.…”

Section: Methodsmentioning

confidence: 99%

“…Physical activity level was determined according to the daily number of exercising hours (inactive, moderate activity, and regular exercise). Annotations were coded from medical charts for additional data such as laboratory tests, nutritional diet (normal or low-salt), prescribed medications, and presence of other diseases and conditions (Youhanna et al 2010). …”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Association of hypertension with coronary artery disease onset in the Lebanese population

et al. 2014

Self Cite

View full text Add to dashboard Cite

The onset of coronary artery disease (CAD) is influenced by cardiovascular risk factors that often occur in clusters and may build on one another. The objective of this study is to examine the relationship between hypertension and CAD age of onset in the Lebanese population. This retrospective analysis was performed on data extracted from Lebanese patients (n = 3,753). Logistic regression examined the association of hypertension with the age at CAD diagnosis after controlling for other traditional risk factors. The effect of antihypertensive drugs and lifestyle changes on the onset of CAD was also investigated. Results showed that hypertension is associated with late onset CAD (OR=0.656, 95% CI=0.504-0.853, p=0.001). Use of antihypertensive drugs showed a similar association with delayed CAD onset. When comparing age of onset in CAD patients with traditional risk factors such as hypertension, diabetes, hyperlipidemia, obesity, smoking and family history of CAD, the age of onset was significantly higher for patients with hypertension compared to those with any of the other risk factors studied (p < 0.001).In conclusion, hypertension and its treatment are associated with late coronary atherosclerotic manifestations in Lebanese population. This observation is currently under investigation to clarify its genetic and/or environmental mechanisms.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Association of hypertension with coronary artery disease onset in the Lebanese population

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…Smoking results in vascular damage in the case of both active and passive smoking. Cessation of smoking significantly reduces the chances of readmission to hospitals, progression of disease, and mortality in CAD patients (24). Smoking in association with CAD is considered a risk factor for the onset of disease, because oxidative stress is involved in the progression of CAD.…”

Section: Discussionmentioning

confidence: 99%

Association of the rs10757274 SNP with coronary artery disease in a small group of a Pakistani population

Nawaz

Noreen²,

Rani³

et al. 2015

Anatol J Cardiol

View full text Add to dashboard Cite

Objective:The present study aimed to investigate the association between the rs10757274 SNP (present on locus 9p21 in the gene for CDKN2B-AS1) and coronary artery disease (CAD) in a local population of Pakistan.Methods:It was a case-control study. An allele-specific PCR-based strategy was used for the identification of genotypes. A total of 350 samples were used for the investigation, out of which 220 samples were CAD patients and 130 samples were normal healthy individuals. Effects of parameters, like family history of CAD, smoking, presence of diabetes, and hypertension, in changing the chances of CAD were studied. Odds ratio was estimated with 95% confidence interval.Results:A strong association was observed between CAD and factors, like smoking (OR: 1.666; 95% CI: 1.042-2.664), presence of hypertension (OR: 26.55; 95% CI: 15.95-44.20), diabetes (OR: 3.009; 95% CI: 1.841-4.920), and family history of CAD (OR: 4.9; 95% CI: 2.965-8.099). Results for the association between the genotype on the basis of rs10757274 showed a strong association between the GG genotype and the occurrence of CAD (OR: 9.603; 95% CI: 5.746-16.05).Conclusion:The present results suggest the importance of the 9p21 locus in modulating the chances of CAD.

show abstract

“…Rather, they share a number of general characteristics, such as a small founder population, rapid outgrowth, a history of isolation, an endogamous genealogy, environmental and phenotypic homogeneity, (McQuillan et al 2008). This homozygosity might contribute risk of health-related conditions (Macgregor et al 2010) and common diseases, like cardiac conditions (Ismail et al 2004;Ushasree et al 2009;Youhanna et al 2010) and some cancers (Denic 2003;Levy-Lahad et al 1995). While relatedness of parents is noted as a risk factor for common complex diseases, individuals within population isolates are at no greater risk for childhood mortality (Bittles and Neel 1994) and might share positive health attributes such as longevity (Altukhov Yu and Sheremet'eva 2000) and increased fertility (Helgason et al 2008).…”

mentioning

confidence: 99%

Pedigree Structure and Kinship Measurements of a Mid-Michigan Community: A New North American Population Isolate Identified

Bonner¹,

Fisher²,

Klein³

et al. 2014

Human Biology

View full text Add to dashboard Cite

Parental consanguinity and family history of coronary artery disease strongly predict early stenosis

Cited by 20 publications

References 16 publications

Association of hypertension with coronary artery disease onset in the Lebanese population

Association of hypertension with coronary artery disease onset in the Lebanese population

Association of the rs10757274 SNP with coronary artery disease in a small group of a Pakistani population

Pedigree Structure and Kinship Measurements of a Mid-Michigan Community: A New North American Population Isolate Identified

Contact Info

Product

Resources

About