Parental chronic widespread pain and the association with chronic widespread pain in adult offspring: Family‐linkage data from the Norwegian <scp>HUNT</scp> Study

Zadro, Joshua R; Nilsen, Tom Ivar Lund; Shirley, Debra; Amorim, Anita B.; Ferreira, Paulo H.; Mork, Paul Jarle

doi:10.1002/ejp.1237

Cited by 10 publications

(9 citation statements)

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“…This nding is consistent with earlier studies of pain in the general population that reported an association between reduced HRQOL and experiencing pain [49]. One possible explanation of the strong negative effect of pain on the physical dimensions of HRQOL is that having persistent pain may affect daily activities such as the ability to exercise and participate in social activities [12,50]. These activities are important to the role as a parent of children at this age.…”

Section: Discussionsupporting

confidence: 90%

Stress, Pain, and Work Affiliation Are Strongly Associated With Health-related Quality of Life in Parents of 14–15-year-old Adolescents

Rohde

Helseth

Mikkelsen

et al. 2021

Preprint

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BackgroundFor many adults, their role as a parent is a vital part of their lives. This role is likely to be associated with a parent’s health-related quality of life (HRQOL). The aim of this study was to explore the associations between gender, demographic and psychosocial variables, and HRQOL pain in parents of 14–15-year-old adolescents.MethodsThis was a cross-sectional study that included 561 parents. Data on demographic, psychosocial variables and pain were collected using validated instruments. HRQOL was assessed using the RAND-36. Data were analysed using univariate and hierarchical multiple linear regression analyses.ResultsFour hundred and thirty-six (78%) mothers and 125 (22%) fathers with a mean age of 45 (SD = 5) years were included. Eighty-one per cent were married/cohabiting, 74% worked full time, and 50% had university education of more than 4 years. Almost one-third reported daily or weekly pain, and more than half (58%) reported using pain analgesics during the previous 4 weeks. Mothers reported significantly lower scores on self-efficacy, self-esteem and for all RAND-36 domains, including the physical component summary (PCS) and mental component summary (MCS) and experienced greater stress than fathers. Hierarchical regression analyses showed that working part-time (beta = 0.40) or full time (beta = 0.52) (reference: not working) had the strongest positive effect on PCS. Absence from work for >10 days (beta = –0.24) (reference: no absence), short-term pain (beta = –0.14), chronic pain (beta = –0.37) (reference: no pain), and stress (beta= –0.10) had the strongest negative effects on PCS. High self-esteem (beta = 0.11) had the strongest positive effect, whereas stress (beta = –0.58) and absence from work for >10 days (beta = –0.11) (reference: no absence) had the strongest negative effects on MCS.ConclusionMothers reported significantly lower scores on self-efficacy, self-esteem, and HRQOL, and experienced greater stress than the fathers. A high proportion of parents reported pain. Pain, stress, and low work affiliation were strongly associated with decreased HRQOL in parents. We recommend that parents of adolescents should be provided guidance about coping with pain and stress, and facilitation of a strong work affiliation because these seem to be important to parents’ HRQOL.

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Section: Discussionsupporting

confidence: 90%

Stress, Pain, and Work Affiliation Are Strongly Associated With Health-related Quality of Life in Parents of 14–15-year-old Adolescents

Rohde

Helseth

Mikkelsen

et al. 2021

Preprint

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“…Vehof and Williams [93] suggested that the once evolutionary advantage of high pain sensitivity may have turned into a genetic predisposition to the neurobiological underpinnings of chronic pain. Parental CWP was shown to increase the risk of CWP in adult offspring, particularly if both parents had CWP, and offspring were obese [41]. Reviewing eight twin studies on CWP, six molecular genetic studies on CWP, and one epigenetic study, the findings by Kerr and Burri [42] suggested that genetic and unique environmental factors contributed to CWP.…”

Section: Resultsmentioning

confidence: 99%

Chronic Widespread Pain and Fibromyalgia Syndrome: Life-Course Risk Markers in Young People

Tan

Jaaniste

Champion

2019

Pain Research and Management

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Although the life-course concept of risk markers as potential etiological influences is well established in epidemiology, it has not featured in academic publications or clinical practice in the context of chronic widespread pain (CWP) and fibromyalgia syndrome (FMS). Studies of risk markers are required considerations for evaluation of patients and for research because there is no single cause, pathological feature, laboratory finding, or biomarker for CWP or FMS. The early-life risk markers identified by extensive literature review with best evidence for potential causal influence on the development and progression of CWP and FMS include genetic factors, premature birth, female sex, early childhood adversity, cognitive and psychosocial influences, impaired sleep, primary pain disorders, multiregional pain, physical trauma, infectious illness, obesity and inactivity, hypermobility of joints, iron deficiency, and small-fiber polyneuropathy. The case history illustrates the potential etiological influence of multiple risk markers offset by personal resilience.

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“…For example, parental chronic MSK pain is associated with increased occurrence of chronic MSK pain in adult offspring [44][45][46], with stronger associations observed when both parents have MSK pain [45; 76]. Furthermore, adults with a sibling with MSK pain have greater odds of experience MSK pain [76].…”

Section: Discussionmentioning

confidence: 99%

Family history of pain and risk of musculoskeletal pain in children and adolescents: a systematic review and meta-analysis

Dario

Kamper

O’Keeffe

et al. 2019

Pain

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Emerging evidence suggests that MSK should be viewed from a biopsychosocial perspective and consider the influence of family factors. We conducted a review with meta-analysis to provide summary estimates of effect of family history of pain on childhood MSK pain, and explore whether specific family pain factors influence the strength of the association (PROSPERO CRD42018090130).Included studies reported associations between family history of pain and non-specific MSK pain in children (age <19 years). The outcome of interest was MSK pain in children. We assessed the methodological quality using a modified version of the Quality in Prognosis Studies instrument, and quality of evidence for the main analyses using the GRADE criteria. After screening of 7281 titles; six longitudinal and 23 cross-sectional studies were included. Moderate quality evidence from five longitudinal studies (n=42131) showed that children with family history of MSK pain had 58% increased odds of experiencing MSK pain themselves (OR 1.58, 95% CI 1.20 to 2.09). Moderate quality evidence from 18 cross-sectional studies (n=17274) supported this finding (OR 2.02, 95% 1.69 to 2.42).Subgroup analyses showed that the relationship was robust regardless of whether a child's mother, father or sibling experienced pain. Odds were higher when both parents reported pain compared to one [(mother OR=1.61; father OR=1.59); both parents OR=2.0]. Our findings show moderate quality evidence that children with a family history of pain are at higher risk of experiencing MSK pain.Understanding the mechanism by which this occurs would inform prevention and treatment efforts.without or with consequences (disability and care seeking), than those without. Further, we aimed to explore whether family pain factors (e.g. which family member report pain, and the type of pain they report) influence the strength of the association. METHOD Design: We conducted a systematic review in accordance with the Meta-analysis Of Observational Studies in Epidemiology checklist [64] and registered the protocol a priori on the International Prospective Register for Systematic Reviews (PROSPERO) (CRD42018090130). Search strategy: The search strategy was designed with the assistance of a research librarian and conducted in four electronic databases: EMBASE, Medline, CINAHL, and Web of Science. We combined four set of descriptors to capture: 1. pain (e.g. musculoskeletal pain), 2. children and adolescents (e.g. pediatrics, child ), 3. family (e.g. mother, father, sibling) and 4. study design (crosssectional, cohort) (Appendix table 1).We considered all records from the inception to April 2019, searches were not restricted by language. Hand searching reference lists of eligible studies supplemented database searches. Inclusion criteria: We included longitudinal and cross-sectional observational studies that reported associations between a family history of pain [defined as pain experienced by an individual's parent(s) or sibling(s)] and MSK pain in children and/or adolescents (mean age<19 years ...

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Parental chronic widespread pain and the association with chronic widespread pain in adult offspring: Family‐linkage data from the Norwegian HUNT Study

Abstract: The parent-offspring transmission of CWP is stronger in obese offspring (particularly when both parents have CWP). This study is the first to investigate the interaction between modifiable lifestyle factors, familial factors and CWP.

Cited by 10 publications

References 60 publications

Stress, Pain, and Work Affiliation Are Strongly Associated With Health-related Quality of Life in Parents of 14–15-year-old Adolescents

Stress, Pain, and Work Affiliation Are Strongly Associated With Health-related Quality of Life in Parents of 14–15-year-old Adolescents

Chronic Widespread Pain and Fibromyalgia Syndrome: Life-Course Risk Markers in Young People

Family history of pain and risk of musculoskeletal pain in children and adolescents: a systematic review and meta-analysis

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