Chronic Widespread Pain and Fibromyalgia Syndrome: Life-Course Risk Markers in Young People

Tan, Aidan Christopher; Jaaniste, Tiina; Champion, G. David

doi:10.1155/2019/6584753

Cited by 25 publications

(14 citation statements)

References 105 publications

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“…On the other hand, fibromyalgia syndrome (FMS) is a chronic widespread pain condition with high heterogeneity clinically and etiologically (16,17). It is estimated that 4-6% of adults worldwide suffer from FMS, whose incidence is increased in women (18).…”

Section: Introductionmentioning

confidence: 99%

A Systematic Review of Efficacy, Safety, and Tolerability of Duloxetine

et al. 2020

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Duloxetine is a serotonin-norepinephrine reuptake inhibitor approved for the treatment of patients affected by major depressive disorder (MDD), generalized anxiety disorder (GAD), neuropathic pain (NP), fibromyalgia (FMS), and stress incontinence urinary (SUI). These conditions share parallel pathophysiological pathways, and duloxetine treatment might be an effective and safe alternative. Thus, a systematic review was conducted following the 2009 Preferred Reporting Items (PRISMA) recommendations and Joanna Briggs Institute Critical (JBI) Appraisals guidelines. Eighty-five studies focused on efficacy, safety, and tolerability of duloxetine were included in our systematic review. Studies were subdivided by clinical condition and evaluated individually. Thus, 32 studies of MDD, 11 studies of GAD, 19 studies of NP, 9 studies of FMS, and 14 studies of SUI demonstrated that the measured outcomes indicate the suitability of duloxetine in the treatment of these clinical conditions. This systematic review confirms that the dual mechanism of duloxetine benefits the treatment of comorbid clinical conditions, and supports the efficacy, safety, and tolerability of duloxetine in short-and long-term treatments.

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Section: Introductionmentioning

confidence: 99%

A Systematic Review of Efficacy, Safety, and Tolerability of Duloxetine

et al. 2020

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“…10 Recent pain studies focus on child and adolescent vulnerability as risk factors for non-resilience. 17,53 Addressing risk factors for vulnerability is an important aspect of chronic pain prevention. 17,54 However, in those living with chronic pain, interventions that promote positive adaptation are more effective than addressing risk factors for maladaptive coping.…”

Section: The Concept Of Resilience In Chronic Painmentioning

confidence: 99%

“…17,53 Addressing risk factors for vulnerability is an important aspect of chronic pain prevention. 17,54 However, in those living with chronic pain, interventions that promote positive adaptation are more effective than addressing risk factors for maladaptive coping. 24,46,55 The literature demonstrates that resilient individuals catastrophize pain less and strength-based approaches (e.g., self-compassion, pain acceptance) to coping with chronic pain are essential to long-term resilience.…”

Section: The Concept Of Resilience In Chronic Painmentioning

confidence: 99%

“…18 In the literature, protective mechanisms or resilience factors are often used to indicate attributes of resilience. 6,10,17,19,27,54 Attributes of resilience in chronic pain are positive affect, prosocial attitude, sense of self, pain acceptance, and active coping.…”

Section: Attributesmentioning

confidence: 99%

“…14,16 Young women with chronic pain face additional challenges, representing an important demographic where appropriate interventions may interrupt the trajectory towards lifelong chronic pain. 15,17 This concept analysis examines resilience in the context of chronic pain, utilizing the Rodgers 18 evolutionary method. Because there are few studies on young women living with chronic pain, particularly on resilience, findings in young women and women of all ages are discussed where possible.…”

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confidence: 99%

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Concept analysis: Resilience in young women with chronic pain

2020

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The aim of this article is to define the concept of resilience in the context of chronic pain, while presenting a historical background of resilience. Resilience in young women with chronic pain is discussed where findings exist. Chronic pain places a considerable burden on individual and societal health; resilience is critical to chronic pain management. Enhancing understanding of the concept of resilience can promote resilience and aid in early recognition of impaired coping. Rodgers's evolutionary method of concept analysis was used. Using CINAHL, PubMed, and Google Scholar databases, articles published from 1979 to 2020 were analyzed to identify conceptual components of resilience. We reviewed included articles to determine surrogate terms, relevant uses of the concept, attributes, references of the concept, antecedents, consequences, and related concepts. Resilience in the context of chronic pain is a lifelong process of positive adaption and thriving despite adversity. Components of Rodgers's evolutionary method are identified for the concept. Further research on resilience in young women with chronic pain is needed, given the current lack of literature. Developing nursing interventions to foster resilience is important to promote long-term, effective self-management of individuals living with chronic pain.

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Morning and evening salivary cortisol levels in patients with chronic widespread pain and those at high risk

Begum

Taylor

Brown

et al. 2021

European Journal of Pain

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Background Hypothalamic‐Pituitary‐Adrenal (HPA) axis dysregulation has been implicated in chronic widespread pain (CWP); the hallmark of fibromyalgia (FM). This is the first study to compare HPA axis changes in individuals with CWP and those at high risk of symptom development. Methods We sought to determine differences in morning and evening salivary cortisol levels in FM (n = 19), those at‐risk (n = 20) and pain‐free controls (n = 17). Risk factors included non‐CWP pain, somatic symptoms, illness behaviour and sleep disturbance. We conducted the study in the absence of centrally acting medication, to address limitations of previous research. Results Repeated measures ANOVA revealed significant main effects of group (p = 0.003), and time of day (p = 0.002), with no significant interaction. Cortisol levels were higher in FM (p = 0.027) and at‐risk (p = 0.003) groups, compared to controls, but there was no significant difference between FM and at‐risk groups. The main effect of group remained significant with sleep problems (p = 0.021) and life events (p = 0.007), but was not significant with anxiety (p = 0.076) or depression (p = 0.098) scores as covariates. With sleep problems as a covariate, cortisol levels remained significantly higher only in the at‐risk group (p = 0.017). Conclusions This study indicates elevated salivary cortisol in FM and those at high risk, and identifies anxiety, depression and sleep problems as potential contributing factors. The results shed light on the dynamic relationship between stress, mood and sleep disorders and the brain's resilience to pain. Significance This study examines neurobiological changes in chronic widespread pain and high risk individuals. One strength of the study is the absence of centrally acting medication. We found high salivary cortisol common to Fibromyalgia and those at risk and identified contributing factors. Our results offer insight into the early mechanistic changes underlying Fibromyalgia development and open up possibilities for early diagnosis and prevention.

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Chronic Widespread Pain and Fibromyalgia Syndrome: Life-Course Risk Markers in Young People

Cited by 25 publications

References 105 publications

A Systematic Review of Efficacy, Safety, and Tolerability of Duloxetine

A Systematic Review of Efficacy, Safety, and Tolerability of Duloxetine

Concept analysis: Resilience in young women with chronic pain

Morning and evening salivary cortisol levels in patients with chronic widespread pain and those at high risk

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