Parental and life-course influences on symptomatic airflow obstruction

Li, Lok Sze Katrina; Williams, Marie; Johnston, Kylie; Frith, Peter; Hyppönen, Elina; Paquet, Catherine

doi:10.1183/23120541.00343-2019

Cited by 9 publications

(7 citation statements)

References 40 publications

(47 reference statements)

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“…69,70 A study from the British birth cohort in 1958 showed that adulthood asthma and smoking status explained about half of the effect of parental respiratory disease history on COPD, and the cumulative effect of asthma (childhood and adulthood reporting of asthma) explained 19% of the effect of parental respiratory disease history on COPD. 86 The results of heterogeneity analysis indicated that the studies of childhood pneumonia, childhood asthma (cohort study), mother smoking in utero and CEIPV (male) were moderately or highly heterogeneous. There are some possible reasons for the heterogeneity: First, these studies differed in race of participants, geographic location and adjusted covariates.…”

Section: Combined Effect Of Early Life Exposures and Adult Exposures On Copdmentioning

confidence: 99%

Impact of early life exposures on COPD in adulthood: A systematic review and meta‐analysis

et al. 2021

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Early life represents a critical period for the development and growth of the lungs. Adverse exposures in this stage may drive the development of chronic obstructive pulmonary disease (COPD). Thus, we quantitatively evaluated the impact of different early life exposures on COPD in adulthood. The PubMed, Embase and Cochrane Library electronic databases were searched for articles published from January 2001 to October 2020. A total of 30 studies (795,935 participants) met the criteria and were included in the review. We found a significant association of COPD with childhood serious respiratory infections, pneumonia or bronchitis (pooled adjusted OR [aOR], 2.23 [95% CI, 1.63-3.07]). The probability of COPD was increased 3.45-fold for children with than without asthma (pooled aOR, 3.45 [95% CI, 2.37-5.02]). In addition, the probability of COPD was associated with maternal smoking (pooled aOR, 1.42 [95% CI, 1.17-1.72]), any child maltreatment (pooled aOR, 1.30 [95% CI, 1.18-1.42]) and low birth weight (pooled aOR, 1.58 [95% CI, 1.08-2.32]) but not childhood environmental tobacco smoke exposure (pooled aOR,) or premature birth (pooled aOR, 1.17 [95% CI, 0.87-1.58]). Furthermore, subgroup analyses revealed that probability was increased for only women with childhood physical abuse, sexual abuse and exposure to intimate partner violence. Factors resulting in COPD in adults could trace back to early life. Childhood respiratory disease, maltreatment, maternal smoking and low birth weight increase the risk of COPD. Promising advances in prevention strategies for early life exposures could markedly decrease the risk of COPD.K E Y W O R D S chronic obstructive pulmonary disease, COPD in adulthood, early life exposure, risk factor, systematic review and meta-analysis

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Section: Combined Effect Of Early Life Exposures and Adult Exposures On Copdmentioning

confidence: 99%

Impact of early life exposures on COPD in adulthood: A systematic review and meta‐analysis

et al. 2021

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“… 28 Further, living with family members who adopt COPD risk behaviors (such as smoking) in childhood may influence the prevalence of COPD in adulthood. 29 , 30…”

Section: Discussionmentioning

confidence: 99%

“…28 Further, living with family members who adopt COPD risk behaviors (such as smoking) in childhood may influence the prevalence of COPD in adulthood. 29,30 An estimated 14% of COPD worldwide is attributable to occupational exposures. 31 A significant relationship between COPD prevalence and occupational exposure was observed in a national study, as well as in Jiangsu, Jiangxi, and Hebei Provinces; 7,9,10,12 however, we did not detect a significant association with occupational exposure in our study, consistent with findings from Anhui Province and the Inner Mongolia Autonomous Region.…”

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confidence: 99%

Chronic Obstructive Pulmonary Disease Prevalence and Associated Risk Factors in Adults Aged 40 Years and Older in Southeast China: A Cross-Sectional Study During 2019–2020

Chen¹,

Yin²,

Zhang³

et al. 2022

COPD

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Purpose Chronic obstructive pulmonary disease (COPD) is one of many major public health problems in China, and its prevalence and associated risk factors in the southeast of China need to be determined to facilitate disease control and prevention. Methods A multistage stratified cluster sampling method was used to select 5486 participants aged ≥ 40 years from nine COPD monitoring districts in Fujian Province during 2019–2020. Participants were interviewed using a laptop-based questionnaire and underwent pulmonary function tests. COPD was diagnosed according to the 2019 Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria. Results Final analysis was conducted using data from 4999 participants with qualified post-bronchodilator results. The prevalence of COPD was 11.6% (95% confidence interval [CI]: 10.5–12.7). Risk factors for COPD in the logistic regression model were being male (odds ratio [OR] = 2.83, 95% CI: 2.01–3.98), > 70 years old (OR = 16.16, 95% CI: 8.14–32.08), having a low body mass index (BMI) (OR = 1.81, 95% CI: 1.13–2.89), parental history of respiratory disease (OR = 1.78, 95% CI: 1.50–2.10), being a current (OR = 2.82, 95% CI: 1.83–4.36) or former (OR = 2.47, 95% CI: 1.45–4.19) smoker, and indoor exposure to biomass (OR = 1.28, 95% CI: 1.05–1.58). Conclusion The estimated prevalence of COPD in southeast China is high. COPD was strongly associated with sex, aging, a low BMI, parental history of respiratory diseases, smoking, and indoor exposure to biomass in adults aged ≥ 40 years. The government should urgently implement comprehensive measures to reduce the risk factors for COPD.

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“…[13][14][15] Furthermore, airflow obstruction is strongly related to increased breathlessness, 1 2 12-15 with asthma being an especially prevalent risk factor at younger ages. 16 While heritability in asthma [17][18][19] and lung function [20][21][22] is well established, it is unknown whether breathlessness clusters across generations. No study has evaluated whether parents with breathlessness are more likely to have offspring with breathlessness or the potential factors underpinning any such association.…”

Section: Introductionmentioning

confidence: 99%

Breathlessness across generations: results from the RHINESSA generation study

Ekström

Johannessen

Abramson

et al. 2021

Thorax

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BackgroundBreathlessness is a major cause of suffering and disability globally. The symptom relates to multiple factors including asthma and lung function, which are influenced by hereditary factors. No study has evaluated potential inheritance of breathlessness itself across generations.MethodsWe analysed the association between breathlessness in parents and their offspring in the Respiratory Health in Northern Europe, Spain and Australia generation study. Data on parents and offspring aged ≥18 years across 10 study centres in seven countries included demographics, self-reported breathlessness, asthma, depression, smoking, physical activity level, measured Body Mass Index and spirometry. Data were analysed using multivariable logistic regression accounting for clustering within centres and between siblings.ResultsA total of 1720 parents (mean age at assessment 36 years, 55% mothers) and 2476 offspring (mean 30 years, 55% daughters) were included. Breathlessness was reported by 809 (32.7%) parents and 363 (14.7%) offspring. Factors independently associated with breathlessness in parents and offspring included obesity, current smoking, asthma, depression, lower lung function and female sex. After adjusting for potential confounders, parents with breathlessness were more likely to have offspring with breathlessness, adjusted OR 1.8 (95% CI 1.1 to 2.9). The association was not modified by sex of the parent or offspring.ConclusionParents with breathlessness were more likely to have children who developed breathlessness, after adjusting for asthma, lung function, obesity, smoking, depression and female sex in both generations. The hereditary components of breathlessness need to be further explored.

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Parental and life-course influences on symptomatic airflow obstruction

Cited by 9 publications

References 40 publications

Impact of early life exposures on COPD in adulthood: A systematic review and meta‐analysis

Impact of early life exposures on COPD in adulthood: A systematic review and meta‐analysis

Chronic Obstructive Pulmonary Disease Prevalence and Associated Risk Factors in Adults Aged 40 Years and Older in Southeast China: A Cross-Sectional Study During 2019–2020

Breathlessness across generations: results from the RHINESSA generation study

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