Parenchymal pineal tumors: a clinicopathological study of 76 cases

Fauchon, F.; Jouvet, Anne; Paquis, Philippe; Saint-Pierre, G; Mottolèse, C.; Hassel, Mohamed Ben; Chauveinc, L.; Sichez, Jean‐Pierre; Philippon, J; Schlienger, M.; Bouffet, Éric

doi:10.1016/s0360-3016(99)00389-2

Cited by 207 publications

(162 citation statements)

References 31 publications

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“…The mixed tumor shows patterns of both pineocytomas and pineoblastomas. In addition to Schild's grading system, Fauchon et al 13) have defined another scale emphasizing the number of mitoses and thereby correlating survival with mitotic activity. These grading scales are relatively recent descriptions, and most series of pineal parenchymal tumors have used the two-tiered grading system.…”

Section: Discussion I Histopathologymentioning

confidence: 99%

“…Chang et al 4) reported a series of 11 adults with pineoblastomas with a median survival of 30 months. Using a grading scale for pineal parenchymal tumors based on number of mitoses, Fauchon et al 13) reported a median survival time of 38 months and 16 months for adult and pediatric patients with the higher grade tumors (grades 3 and 4), respectively. Schild et al 33) reported a 5-year survival rate of 58% for the 21 adult and pediatric patients with mixed, intermediate, or pure pineoblastomas.…”

Section: Survivalmentioning

confidence: 99%

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Management and Survival of Pineoblastoma: An Analysis of 34 Adults From the Brain Tumor Registry of Japan

Lee

Wakabayashi

Yoshida

2005

Neurol. Med. Chir.(Tokyo)

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Pineoblastoma is a rare tumor in adults, and factors influencing survival are poorly understood. Data from the Brain Tumor Registry of Japan (BTRJ) was analyzed to examine patient, tumor, and treatment characteristics associated with increased survival in adults with pineoblastomas. All pineoblastoma cases in adults aged 16 years or older were identified in the BTRJ. Data were extracted on demographics, presentation, tumor characteristics, treatments, and outcomes. Kaplan-Meier plots, the log rank method, and p value º0.15 was used to screen variables for inclusion in a multivariate Cox regression estimating survival. In the final Cox multivariate model, all variables with p values º0.05 were considered significant predictors of survival, and all variables with p values 0.05-0.099 were considered trends. The BTRJ contained 34 adults with pineoblastomas diagnosed from 1969-1998. The patients were predominantly male (22 patients), with a median age of 35 years (range 16-66 years). Median survival from diagnosis was 25.7 months, with a median follow up of 20.5 months. Median surgical resection was 75-94%, and five of the 34 patients had gross total resection. Twenty-nine of the 34 patients received cranial irradiation therapy with a median dose of 50 Gy (range 30-70 Gy). In the final multivariate model, cranial irradiation AE40 Gy (p ＝ 0.014) and gross total resection (p ＝ 0.034) were associated with improved survival. There was a trend towards improved survival for women (p ＝ 0.099). Adult pineoblastoma patients have poor survival prognosis. Cranial irradiation therapy using at least 40 Gy and complete surgical resection are associated with improved survival.

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Section: Discussion I Histopathologymentioning

confidence: 99%

Section: Survivalmentioning

confidence: 99%

Management and Survival of Pineoblastoma: An Analysis of 34 Adults From the Brain Tumor Registry of Japan

Lee

Wakabayashi

Yoshida

2005

Neurol. Med. Chir.(Tokyo)

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“…However, no pineocytomas have been shown to metastasize, and the 5-year survival of patients with PPTID ranges from 39% to 74% in a series of strictly classified tumors. 6) These findings suggest that these two tumor entities are also unlikely to be the primary tumors.…”

Section: Discussionmentioning

confidence: 97%

Central Nervous System Primitive Neuroectodermal Tumor of Spinal Cord Developing 20 Years After Curative Treatment of Pineal Tumor -Case Report-

Fujisawa

Kaneko

Tohma

et al. 2011

Neurol. Med. Chir.(Tokyo)

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A 65-year-old male who had previously received curative treatment for a pineal tumor presented with an extremely rare case of primary central nervous system (CNS) primitive neuroectodermal tumor (PNET) of the spinal cord manifesting as progressive tetraparesis. Although the histology was not verified, highly radiosensitive tumor was suspected because of the benign clinical course for over 20 years after only radiation therapy. Magnetic resonance imaging demonstrated an intramedullary tumor extending from C5 to T1. He underwent partial resection and histological examination revealed blue tumor with undifferentiated small round cells. Immunohistochemically, c-kit was negative but CD99 was strongly and diffusely positive. Therefore, rearrangement of the Ewing sarcoma gene was examined to determine the presence of peripheral type of PNET. The results were negative and systemic workup revealed no other disease. These findings led to the diagnosis of primary intramedullary CNS PNET of the spinal cord, and suggested that the spinal cord tumor occurred independently of the prior pineal disease. The residual tumor was controlled by postoperative local radiation therapy.

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“…This is a category of an aggressive group of supratentorial primitive neuroectodermal tumors (PNET). Due to its rarity there are few studies evaluating therapeutic strategies on this condition and debate about the best therapeutic approach is still an open issue [2,3] . The recommended care includes maximal surgical resection followed by adjuvant craniospinal radiotherapy and, less consistently, systemic chemotherapy that includes several different protocols that vary widely, but often include the combination of at least two of the following drugs: cisplatin or carboplatin, cyclophosphamide and lomustine, vincristine.…”

Section: Introductionmentioning

confidence: 99%

Treatment of a Pineoblastoma in a 51-year-old patient

Abrahão

Alessandretti

Moreira

et al. 2014

CRCP

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Malignant pineal tumors are rare entities in adult patients, comprising less than 1% of primary central nervous system neoplasms.Herein, we report a 51-years-old patient with pineoblastoma with clinical manifestation, follow up MRI, treatment receive and the response to chemotherapy treatment.Adjuvant chemotherapy with cisplatin, etoposide and cyclophosphamide followed by radiotherapy has also been used to manage pineoblastoma in adults. The present case suggests that the case which total gross resection is not feasible, delivering chemotherapy instead of radiotherapy, can be considered an option.

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Parenchymal pineal tumors: a clinicopathological study of 76 cases

Cited by 207 publications

References 31 publications

Management and Survival of Pineoblastoma: An Analysis of 34 Adults From the Brain Tumor Registry of Japan

Management and Survival of Pineoblastoma: An Analysis of 34 Adults From the Brain Tumor Registry of Japan

Central Nervous System Primitive Neuroectodermal Tumor of Spinal Cord Developing 20 Years After Curative Treatment of Pineal Tumor -Case Report-

Treatment of a Pineoblastoma in a 51-year-old patient

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