Classification of hypothalamic hamartomas into these two categories based on MR findings resulted in a clear correlation between symptoms and the subsequent clinical course.
Abstract. A data set containing more than 6 years (February 2009 to present) of radiance spectra for carbon dioxide (CO 2 ) and methane (CH 4 ) observations has been acquired by the Greenhouse gases Observing SATellite (GOSAT, available at http://data.gosat.nies.go.jp/ GosatUserInterfaceGateway/guig/GuigPage/open.do), nicknamed "Ibuki", Thermal And Near infrared Sensor for carbon Observation Fourier Transform Spectrometer (TANSO-FTS). This paper provides updates on the performance of the satellite and TANSO-FTS sensor and describes important changes to the data product, which has recently been made available to users. With these changes the typical accuracy of retrieved column-averaged dry air mole fractions of CO 2 and CH 4 (X CO 2 and X CH 4 , respectively) are 2 ppm or 0.5 % and 13 ppb or 0.7 %, respectively. Three major anomalies of the satellite system affecting TANSO-FTS are reported: a failure of one of the two solar paddles in May 2014, a switch to the secondary pointing system in January 2015, and most recently a cryocooler shutdown and restart in August 2015. The Level 1A (L1A) (raw interferogram) and the Level 1B (L1B) (radiance spectra) of version V201 described here have longterm uniform quality and provide consistent retrieval accuracy even after the satellite system anomalies. In addition, we discuss the unique observation abilities of GOSAT made possible by an agile pointing mechanism, which allows for optimization of global sampling patterns.
Alkylating agents, such as temozolomide, are among the most effective cytotoxic agents used for malignant gliomas, but responses remain very poor. The DNA repair protein O 6 -methylguanine-DNA methyltransferase (MGMT) plays an important role in cellular resistance to alkylating agents. IFN-B can act as a drug sensitizer, enhancing toxicity against a variety of neoplasias, and is widely used in combination with other antitumor agents such as nitrosoureas. Here, we show that IFN-B sensitizes glioma cells that harbor the unmethylated MGMT promoter and are resistant to temozolomide. By means of oligonucleotide microarray and RNA interference, we reveal that the sensitizing effect of IFN-B was possibly due to attenuation of MGMT expression via induction of the protein p53. Our study suggests that clinical efficacy of temozolomide might be improved by combination with IFN-B using appropriate doses and schedules of administration. (Cancer Res 2005; 65(17): 7573-9)
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