Parenchymal Emphysema Measured by CT Lung Density Correlates With Lung Function in Patients With Bullous Disease

Gould, G. A.; Redpath, Anthony Thomas; Ryan, Marissa; Warren, P.M.; Best, J. J. K.; Cameron, Euan; MacNee, William

doi:10.1016/s0012-3692(16)47462-3

Cited by 21 publications

(16 citation statements)

References 21 publications

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“…The difference between their study and ours could be explained by the fact that their CT measurements were obtained at FRC rather than at full expiration. However, this does not entirely explain why they did not confirm the correlation between CT lung density measurement and OLcO that we and others (14,32,36,38,(41)(42)(43) have found. However, there are a number of variables that are not considered in the study by Heremans and coworkers (40).…”

Section: Discussioncontrasting

confidence: 98%

Radiologic evaluation of emphysema in patients with chronic obstructive pulmonary disease. Chest radiography versus high resolution computed tomography.

Miniati¹,

Filippi²,

Falaschi³

et al. 1995

Am J Respir Crit Care Med

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To objectively reappraise the role of the chest radiograph (CXR) in the clinical assessment of emphysema, we compared a standardized reading of CXR with both a visual scoring and a quantitative analysis of high resolution computed tomography (HRCT) of the chest in 46 consecutive patients with chronic obstructive pulmonary disease (COPD) and fixed expiratory airflow limitation. CXR were scored for signs of overinflation and pulmonary vascular deficiency by three independent observers. HRCT scans were independently scored for extent of emphysema and for both severity and extent of emphysema. In 28 of 46 patients, inspiratory and expiratory HRCT scans were analyzed quantitatively by measuring the mean CT number in Hounsfield Units (HU) and the percentage of lung area with CT numbers < -900 HU. Quantitative CT data were compared with reference values obtained in seven normal nonsmokers. The CXR score of emphysema showed a highly significant interobserver reproducibility and correlated linearly (p < 0.001) with HRCT visual scores and quantitative data from both inspiratory and expiratory CT scan. CXR score correlated with functional indices of airflow obstruction, overinflation, and impaired lung diffusing capacity in a way comparable to that obtained by using qualitative and quantitative CT data. Patients with no signs of emphysema on CXR had mean expiratory CT numbers within normal range and a fraction of lung area with CT numbers < -900 HU on expiratory scan not exceeding 15% of total cross-sectional area. The latter value was consistently greater than 15% in patients with CXR score > 0.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussioncontrasting

confidence: 98%

Radiologic evaluation of emphysema in patients with chronic obstructive pulmonary disease. Chest radiography versus high resolution computed tomography.

Miniati¹,

Filippi²,

Falaschi³

et al. 1995

Am J Respir Crit Care Med

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“…Another goal was to classify the emphysematous destruction by their type. As emphysema is divided into two main types: bullous emphysema or nonbullous small-sized bullae emphysema, we defined the classification of the as being the relation of large emphysema bullae to small emphysema bullae : : (11) with (12) The varies from 1 to 1, corresponding nonbullous to bullous type, respectively. The classifier is only meaningful, if the area of class 2 to 4 (12) exceeds a certain amount of the .…”

Section: B the New Algorithm In Detailmentioning

confidence: 99%

“…Other research groups use the mean lung density [12], the full-width at half-maximum of the density histogram [30] or the fifth or tenth percentile of the CT histogram data [11], [37]. All mentioned methods only consider the total area of air-filled lung 0278-0062/01$10.00 ©2001 IEEE regions, and not their distribution.…”

Section: Introductionmentioning

confidence: 99%

Automated CT image evaluation of the lung: a morphology-based concept

Blechschmidt

Werthschützky

Lörcher

2001

IEEE Trans. Med. Imaging

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“…In adults with asthma it has been shown that considerable alveolar tissue inflammation is present that contributes to lung function abnormalities in these patients (41). In patients with COPD severe airflow obstruction is related to destruction of peribronchial alveoli (42), reduced density of the lung parenchyma (43), and a larger distance between alveolar attachments (44). It is likely that airways in emphysematous lungs are irregular and distorted (45,46).…”

Section: Parenchymamentioning

confidence: 99%