The Role of Inflammation in Airway Disease

Tiddens, Harm A.W.M.; Silverman, Michael; Bush, Andrew

doi:10.1164/ajrccm.162.supplement_1.maic-2

Cited by 66 publications

(49 citation statements)

References 59 publications

(78 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Airway hyperreactivity is a pathophysiologic response to multiple stimuli released from peribronchial inflammatory cells. Eosinophil recruitment is prominent throughout the response to allergens, and mediators released by these cells foster the development of irreversible airway remodeling (32,33). Lymphocytes and APCs contribute through the Th2-driven production of allergen-specific IgE Abs in secondary lymphoid organs.…”

Section: Discussionmentioning

confidence: 99%

E- and P-Selectins Are Essential for the Development of Cockroach Allergen-Induced Airway Responses

Lukacs

John

Berlin

et al. 2002

The Journal of Immunology

View full text Add to dashboard Cite

Peribronchial inflammation contributes to the pathophysiology of allergic asthma. In many vascular beds, adhesive interactions between leukocytes and the endothelial surface initiate the recruitment of circulating cells. Previous studies using OVA-induced airway hyperreactivity indicated that P-selectin, a member of the selectin family expressed by activated platelets and endothelium, contributed to both inflammation and bronchoconstriction. The current study used cockroach allergen (CRA), an allergen that induces asthmatic responses in both humans and mice, to further investigate the role of selectins in the development of peribronchial inflammation and airway hyperreactivity. P- and E-selectin mRNAs were detected in extracts of CRA-sensitized animals beginning shortly after intratracheal challenge with CRA. The P-selectin mRNA was transiently induced at early time points while up-regulation of the E-selectin mRNA was more prolonged. Mice with targeted deletions in E-selectin (E−), P-selectin (P−), and both genes (E−/P−) showed 70–85% reductions in airway hyperreactivity, peribronchial inflammation, and eosinophil accumulation. The P− and E−/P− groups showed the most profound reductions. The transfer of splenic lymphocytes from CRA-primed E−/P− into naive wild-type (WT) mice produced the same level of airway hyperreactivity as transfers from CRA-primed WT into naive WT hosts, indicating that peripheral immunization was similar. The observed changes in the selectin-deficient animals were not related to inadequate sensitization, because CRA priming and challenge increased serum IgE levels. Furthermore, pulmonary Th2-type cytokines and chemokines in the E-selectin−/− and WT animals were similar. The findings indicate that both P- and E-selectin contribute to CRA-induced peribronchial inflammation and airway hyperreactivity.

show abstract

Section: Discussionmentioning

confidence: 99%

E- and P-Selectins Are Essential for the Development of Cockroach Allergen-Induced Airway Responses

Lukacs

John

Berlin

et al. 2002

The Journal of Immunology

View full text Add to dashboard Cite

show abstract

“…This airway remodeling may lead to long-term morbidity, including irreversible airway obstruction. 8,9 Even more notable is the potential for a severe episode of EIB leading to mortality in competitive athletes. Results of a 7-y study by Becker et al 10 reported 61 EIB-related deaths during competition or practice, with 81% of these deaths occurring in athletes Ͻ21 y old.…”

Section: See the Related Editorial On Page 994mentioning

confidence: 99%

Perception of Exercise-Induced Bronchoconstriction in College Athletes

et al. 2016

View full text Add to dashboard Cite

BACKGROUND: Exercise-induced bronchoconstriction (EIB) can lead to long-term respiratory illness and even death. EIB prevalence rates are both high and variable in college athletes. Also, prevalence rates may be underestimated due to ineffective screening. The purpose of this study is to investigate the prevalence of EIB and the perceived impact of EIB in college athletes via a self-report questionnaire. METHODS: A self-report EIB questionnaire was administered to college athletes on 8 different sports teams. Information collected was used to identify athletes who selfreported: (1) a history of EIB and/or asthma, (2) respiratory symptoms during exercise, (3) medication use, and (4) concern about EIB. RESULTS: Results showed that 56 of 196 athletes (28.6%) self-reported a history of EIB or asthma. Over half (52%) reported a history of EIB/asthma or current EIB symptoms. Forty-six of the 140 athletes (32.9%) who did not report a history of EIB or asthma indicated symptoms of EIB during sports, training, or exercise. Fourteen of 56 athletes (25%) self-reporting a history of EIB or asthma did not report the use of a respiratory medication. Nineteen of 196 athletes (9.7%) reported being concerned that EIB was adversely affecting their sports performance. CONCLUSIONS: College athletes self-report a high prevalence of EIB or asthma. Although college athletes may not report a history of EIB or asthma, they indicate symptoms of EIB. A majority of athletes reported a history or current symptoms related to EIB or asthma. Many athletes with a history of EIB or asthma are not taking any asthma medication. Last, athletes report concern about EIB adversely affecting their sports performance. More work is needed using a combination of a screening questionnaire and standardized EIB testing to develop a validated tool for accurately screening and diagnosing EIB in college athletes.

show abstract

“…Airway disease in CF is characterised by mucus plugging, chronic infection and an excessive inflammatory response, leading to peripheral airway changes in the first few months of life [101][102][103][104][105][106][107][108][109][110][111][112][113][114][115][116][117][118][119]. The characteristic airway abnormalities are bronchiectasis, thickening of the airway wall and mucus plugging [97,103,107,[120][121][122][123][124][125][126], as shown in figure 5.…”

Section: Airway Imaging In Cystic Fibrosismentioning

confidence: 99%

Computed tomographic imaging of the airways: relationship to structure and function

Jong

Müller²,

Paré³

et al. 2005

Eur Respir J

156

View full text Add to dashboard Cite

Alterations in the structure of the airways, collectively termed airway remodelling, contribute to airflow obstruction in a variety of chronic lung diseases. While histology has provided valuable insights into the structure of airway wall remodelling, this technique is invasive and does not allow the longitudinal analysis of airway wall dimensions. Technical advances in computed tomography allow the assessment of airway wall dimensions, and are ideally suited for the noninvasive investigation of the pathogenesis of airway wall remodelling and the evaluation of new therapeutic interventions. The aim of this article is to review the use of computed tomography in the investigation of airway structure and function in health and disease.

show abstract

The Role of Inflammation in Airway Disease

Cited by 66 publications

References 59 publications

E- and P-Selectins Are Essential for the Development of Cockroach Allergen-Induced Airway Responses

E- and P-Selectins Are Essential for the Development of Cockroach Allergen-Induced Airway Responses

Perception of Exercise-Induced Bronchoconstriction in College Athletes

Computed tomographic imaging of the airways: relationship to structure and function

Contact Info

Product

Resources

About