Parecoxib vs. lornoxicam in the treatment of postoperative pain after laparoscopic cholecystectomy: a prospective randomized placebo-controlled trial

Abstract

Parecoxib 40 mg i.v. and lornoxicam 8 mg i.v. were equianalgesic and both were more efficacious than placebo for the management of pain after laparoscopic cholecystectomy.

Multiple-, But Not Single-, Dose of Parecoxib Reduces Shoulder Pain after Gynecologic Laparoscopy

“…To date, however, appropriate dosage and timing of parecoxib are still not clear. Akaraviputh et al indicated that preoperative infusion 20mg parecoxib could reduce the postoperative opioid consumption 30, and Papadima et al showed that preoperative parecoxib 40mg was efficacious for pain control and opioids sparing following laparoscopic cholecystectomy 31. In another study, parecoxib 40 mg twice daily attenuated worst pain in laparoscopic cholecystectomy32, but a latest study found that the efficacy of same medication on piritramide consumption and pain relief was weak 33.…”

Efficacy of lornoxicam for acute postoperative pain relief after septoplasty: a comparison with diclofenac, ketoprofen, and dipyrone

“…Lornoxicam was found to be as effective as parecoxib, a recently used cyclooxygenase-2 inhibitor, for the relief of postoperative pain [18]. Lornoxicam also was found to be more effective than paracetamol in providing pain relief after minor gynecologic operations [13] and was more effective than ketoprofen after abdominal hysterectomy or either ketoprofen or ketorolac after oncologic surgery [15].…”

Parecoxib sodium reduces the need for opioids after tonsillectomy in children: a double-blind placebo-controlled randomized clinical trial

“…8 It is often administered for the management of postoperative pain in adults and is generally well tolerated. 9 The primary objective of the present study was to evaluate the opioid-sparing effect of a single intravenous dose of parecoxib sodium in children undergoing tonsillectomy. The secondary objective of the trial was to assess the common adverse effects.…”

“…The median (interquartile range [IQR]) Children's Hospital of Eastern Ontario Pain Scale scores in the postanesthesia care unit were lower in Group P than in Group S (7 [5][6][7][8] vs 9 [8][9][10][11], respectively; P = 0.001). The incidence of postoperative nausea and vomiting (PONV) was higher in Group S than in Group P [11/30 (37%) vs 4/30 (13%), respectively; RR, 2.8; 95% CI, 1.0 to 7.7; P = 0.037].…”