Paratuberculosis with special reference to cattle A review

Olsen, Ingrid; Siguroardóttir, Olöf; Djønne, Berit

doi:10.1080/01652176.2002.9695120

Cited by 73 publications

(112 citation statements)

References 119 publications

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“…La prueba basada en hipersensibilidad cutánea retardada ha sido utilizada con éxito para el diagnóstico de paratuberculosis, y tiene la ventaja de ser una prueba fácil de aplicar y de leer en el hato (13,14). Sin embargo, la prueba se considera de baja especificidad (15). El diagnóstico histopatológico de paratuberculosis es un método ampliamente utilizado y sugerido para la identificación de animales infectados y afectados por la enfermedad, y para evaluar la persistencia de MAP y la severidad de la respuesta inmune mediada por células en el hospedero (3).…”

Section: Introductionunclassified

Diagnóstico clínico e histopatológico de paratuberculosis bovina en un hato lechero en Colombia

Ramírez

Rodríguez

2011

Rev MVZ Córdoba

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RESUMENObjetivo. Analizar retrospectiva y sistemáticamente los hallazgos clínicos e histopatológicos de paratuberculosis bovina Mycobacterium avium subsp. Paratuberculosis (MAP). Los datos fueron obtenidos en diferentes momentos durante un periodo de 8 años (2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008) en un hato lechero en Colombia. Materiales y métodos. Se analizó la información documental en 5 casos compatibles con paratuberculisis bovina, así como la información procedente de otros estudios efectuados en el hato sobre la enfermedad realizados paralelamente en el periodo 2000-2008. Resultados. Los 5 animales afectados, presentaron diarrea crónica intermitente, disminución en la producción de leche, enflaquecimiento progresivo, apetito normal, consumo aumentado de agua y constantes fisiológicas normales. A la necropsia se observó engrosamiento de la mucosa intestinal del íleon y de la porción proximal del intestino grueso con múltiples levantamientos y depresiones, que no desaparecían al estirar el tejido. Los vasos sanguíneos mesentéricos se encontraron dilatados y congestivos. Los ganglios linfáticos mesentéricos se encontraron aumentados hasta tres veces, sin clara delimitación de la corteza y de la médula. Las alteraciones histológicas fueron enteritis y linfadenitis granulomatosa. En tres de los animales se evidenciaron abundantes bacilos ácido alcohol resistentes (BAAR) intracelulares en macrófagos, células gigantes y en el intersticio a la coloración de Ziehl-Neelsen. En otros tejidos evaluados no se encontró inflamación de tipo granulomatoso. Conclusiones. Los criterios diagnósticos empleados, así como el análisis de la información diagnóstica generada en otros estudios, permiten confirmar la presencia, circulación y mantenimiento del Mycobacterium avium subsp. paratuberculosis en el hato con un aparente número elevado de animales infectados.Palabras clave: Enfermedades en bovinos, Mycobacterium avium, paratuberculosis (Fuente: CAB). ABSTRACTObjective. To analyze retrospectively and systematicaly the histological and clinical findings of bovine paratuberculosis Mycobacterium avium subsp. Paratuberculosis (MAP). The data were obtained at different times over a period of 8 years (2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008) in a dairy herd in Colombia. Materials and methods. Historical data of clinical and histopathological findings, in five cases compatible with bovine paratuberculosis, were studied. Additional information was also analysed from other studies related to the disease in the herd in the same period of time. Results. The infected animals showed intermittent chronic diarrhea, decreased production of milk, progressive weight loss, normal appetite, increased water consumption and normal physiological constants. The necropsy revealed variable thickening of the intestinal mucous membrane in the ileum and proximal portion of the large intestine with multiple uprisings and depressions, which did not disappear in the stretched tissue. Mesenteric vessels were dilated and congestiv...

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Section: Introductionunclassified

Diagnóstico clínico e histopatológico de paratuberculosis bovina en un hato lechero en Colombia

Ramírez

Rodríguez

2011

Rev MVZ Córdoba

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“…paratuberculosis (M. paratuberculosis) (46,59). The disease occurs worldwide and is primarily a disease of domesticated ruminants, including cattle (both beef and dairy), sheep, goats, and farmed deer.…”

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Molecular Epidemiology of Mycobacterium avium subsp. paratuberculosis Isolates Recovered from Wild Animal Species

et al. 2004

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Mycobacterial isolates were obtained by radiometric culture from 33 different species of captive or freeranging animals (n ‫؍‬ 106) and environmental sources (n ‫؍‬ 3) from six geographic zones within the United States. The identities of all 109 isolates were confirmed by using mycobactin J dependence and characterization of five well-defined molecular markers, including two integration loci of IS900 (loci L1 and L9), one Mycobacterium avium subsp. paratuberculosis (M. paratuberculosis)-specific sequence (locus 251), and one M. avium subsp. avium-specific marker (

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“…Este teste apresenta baixo custo operacional e é de fácil execução, porém a sua sensibilidade é baixa e evidencia apenas micobactérias com a parede celular íntegra; a não visualização de BAARs nas amostras analisadas pode estar associada à presença de bactérias degradadas ou com envoltório celular modificado (esferoplastos) (Olsen et al 2002, Martinson et al 2008). …”

Section: Coloração De Znunclassified

Diagnóstico imuno-histopatológico da paratuberculose subclínica em bovinos no estado do Rio de Janeiro

et al. 2013

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RESUMO.-O diagnóstico precoce e específico da paratuberculose ainda é um desafio. Isto pode estar associado à baixa sensibilidade dos testes laboratoriais e ou à variação da resposta imunológica frente à infecção por Mycobacterium avium subsp. paratuberculosis. The early and specific diagnosis of paratuberculosis remains a challenge due to the low sensitivity of the currently available laboratory tests and also because of variations in the immune response towards infection with Mycobacterium avium subsp. paratuberculosis. Globally this disease causes significant economic losses, primarily in dairy cattle, owing to the chronic nature of the infection. Paratuberculosis has been described in a number of Brazilian states and from a diversity of domestic ruminant species clearly demonstrating that the disease is present in the country and highlighting the requirement for the development of diagnostic techniques for confirmation of infection and for epidemiological analyses. The aim of this study was to characterize the anatomo-histopathological and immunohistochemical findings in the bowel and mesenteric lymph nodes of assymptomatic cattle, derived from paratuberculosis positive herds located in state of Rio de Janeiro, Brazil. Macroscopic examination during necropsy revealed nonspecific changes including reddening of the gut mucosa, increased volumes for the Peyer's patches and mesenteric lymph nodes and in some case dilation and whitening of the mesenteric lymphatic vessel. Histopathology revealed granulomatous infiltration, occasionally with the formation of giant cells in the jejunal and ileal mucosa or sub-mucosa, and/or in the cortical region of the mesenteric lymph nodes, in 32 of the 52 cattle examined. Tissue sections from these animals were subjected to Ziehl-Neelsen staining, but the presence of acid-fast bacilli was not observed. Subsequent analysis, employing genus specific immunohistochemisty for Mycobacterium, revealed areas of immunoreactivity in sections prepared from a total of six animals. The results of this investigation highlighted the value of histopathology and particularly immunohistochemistry as tools for the diagnosis of subclinical paratuberculosis.

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Paratuberculosis with special reference to cattle A review

Cited by 73 publications

References 119 publications

Diagnóstico clínico e histopatológico de paratuberculosis bovina en un hato lechero en Colombia

Diagnóstico clínico e histopatológico de paratuberculosis bovina en un hato lechero en Colombia

Molecular Epidemiology of Mycobacterium avium subsp. paratuberculosis Isolates Recovered from Wild Animal Species

Diagnóstico imuno-histopatológico da paratuberculose subclínica em bovinos no estado do Rio de Janeiro

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