Parathyroid-on-a-chip simulating parathyroid hormone secretion in response to calcium concentration

Lee, Sunghan; Jung, Hyo-Il; Lee, Jaehun; Kim, Youngwon; Chung, Jaewoo; Kim, Han Su; Lim, Jiseok; Nam, Ki Chang; Lim, Yun-Sung; Choi, Han Seok; Kwak, Bong Seop

doi:10.1039/d4lc00249k

Lab Chip

2024

DOI: 10.1039/d4lc00249k

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Parathyroid-on-a-chip simulating parathyroid hormone secretion in response to calcium concentration

Sunghan Lee,

Hyo-Il Jung,

Jaehun Lee

et al.

Abstract: The parathyroid gland is an endocrine organ that plays a crucial role in regulating calcium levels in the blood serum through the secretion of parathyroid hormone (PTH). Hypothyroidism is a...

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Bone-on-a-chip simulating bone metastasis in osteoporosis

Lee,

Kim,

Jung

et al. 2024

Biofabrication

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Osteoporosis is the most common bone disorder, which is a highly dangerous condition that can promote bone metastases. As the current treatment for osteoporosis involves long-term medication therapy and a cure for bone metastasis is not known, ongoing efforts are required for drug development for osteoporosis. Animal experiments, traditionally used for drug development, raise ethical concerns and are expensive and time-consuming. Organ-on-a-chip technology is being developed as a tool to supplement such animal models. In this study, we developed a bone-on-a-chip by co-culturing osteoblasts, osteocytes, and osteoclasts in an extracellular matrix (ECM) environment that can represent normal bone, osteopenia, and osteoporotic conditions. We then simulated bone metastases using breast cancer cells in three different bone conditions and observed that bone metastases were most active in osteoporotic conditions. Furthermore, it was revealed that the promotion of bone metastasis in osteoporotic conditions is due to increased vascular permeability. The bone-on-a-chip developed in this study can serve as a platform to complement animal models for drug development for osteoporosis and bone metastasis.

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Bone-on-a-chip simulating bone metastasis in osteoporosis

Lee,

Kim,

Jung

et al. 2024

Biofabrication

View full text Add to dashboard Cite

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Parathyroid-on-a-chip simulating parathyroid hormone secretion in response to calcium concentration

Abstract: The parathyroid gland is an endocrine organ that plays a crucial role in regulating calcium levels in the blood serum through the secretion of parathyroid hormone (PTH). Hypothyroidism is a...

Cited by 1 publication

References 54 publications

Bone-on-a-chip simulating bone metastasis in osteoporosis

Bone-on-a-chip simulating bone metastasis in osteoporosis

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