Parathyroid Hormone Secretion Is Controlled by Both Ionized Calcium and Phosphate During Exercise and Recovery in Men

Townsend, Rebecca; Elliott‐Sale, Kirsty J.; Pinto, Ana Jéssica; Thomas, C. B.; Scott, Jonathan; Currell, Kevin; Fraser, William D.; Sale, Craig

doi:10.1210/jc.2016-1848

Cited by 36 publications

(25 citation statements)

References 41 publications

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“…For example, in an early series of studies of young men by Ljunghall and colleagues, (17)(18)(19)(20) brief highintensity exercise caused an increase in serum iCa with no change in PTH, prolonged low-intensity exercise caused a decrease in serum iCa and increase in PTH, and less prolonged moderate-intensity exercise tended to increase PTH despite no decrease or an increase in iCa. A more recent series of studies of young men by Scott and colleagues (11) and Townsend and colleagues (21) confirmed that the PTH response to exercise is intensity dependent (ie, higher intensity, higher PTH response). The studies further suggested that the increase in PTH occurred with no decrease in serum tCa; iCa was not measured.…”

Section: Ca and Pth Responses To Exercise: Overviewmentioning

confidence: 91%

Maintenance of Serum Ionized Calcium During Exercise Attenuates Parathyroid Hormone and Bone Resorption Responses

Kohrt

Wherry

Wolfe

et al. 2018

Journal of Bone and Mineral Research

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Exercise can cause a decrease in serum ionized calcium (iCa) and increases in parathyroid hormone (PTH) and bone resorption. We used a novel intravenous iCa clamp technique to determine whether preventing a decline in serum iCa during exercise prevents increases in PTH and carboxy-terminal collagen crosslinks (CTX). Eleven cycling-trained men (aged 18 to 45 years) underwent two identical 60-min cycling bouts with infusion of Ca gluconate or saline. Blood sampling for iCa, total calcium (tCa), PTH, CTX, and procollagen type 1 amino-terminal propeptide (P1NP) occurred before, during, and for 4 hours after exercise; results are presented as unadjusted and adjusted for plasma volume shifts (denoted with subscript ADJ). iCa decreased during exercise with saline infusion (p = 0.01 at 60 min) and this was prevented by Ca infusion (interaction, p < 0.007); there were abrupt decreases in Ca content (iCa and tCa ) in the first 15 min of exercise under both conditions. PTH and CTX were increased at the end of exercise (both p < 0.01) on the saline day, and markedly attenuated (-65% and -71%; both p < 0.001) by Ca. CTX remained elevated for 4 hours after exercise on the saline day (p < 0.001), despite the return of PTH to baseline by 1 hour after exercise. P1NP increased in response to exercise (p < 0.001), with no difference between conditions, but the increase in P1NP was not significant. Results for PTH and CTX were similar to unadjusted results. These findings demonstrate that bone resorption is stimulated early in exercise to defend serum iCa. Vascular Ca content decreased early in exercise, but neither the reason why this occurred, nor the fate of Ca, are known. The results suggest that the exercise-induced increase in PTH had an acute catabolic effect on bone. Future research should determine whether the increase in PTH generates an anabolic response that occurs more than 4 hours after exercise. © 2018 American Society for Bone and Mineral Research.

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Section: Ca and Pth Responses To Exercise: Overviewmentioning

confidence: 91%

Maintenance of Serum Ionized Calcium During Exercise Attenuates Parathyroid Hormone and Bone Resorption Responses

Kohrt

Wherry

Wolfe

et al. 2018

Journal of Bone and Mineral Research

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“…Similarly, Townsend et al found that circulating PTH concentrations decreased with the onset of exercise, then increased in an intensity-dependent manner, with the highest levels recorded at the end of exercise performed at 75% VO 2 max and at 5–7.5 min after exercise. Phosphate levels paralleled the PTH changes, as did ionized calcium, though with an inverse pattern; PTH concentrations negatively correlated with Ca 2+ levels across all intensities [ 176 ].…”

Section: Regulation Of Pth Secretion and Pth-dependent Calcium-phomentioning

confidence: 99%

Physical Activity-Dependent Regulation of Parathyroid Hormone and Calcium-Phosphorous Metabolism

Lombardi

Ziemann²,

Banfi

et al. 2020

IJMS

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Exercise perturbs homeostasis, alters the levels of circulating mediators and hormones, and increases the demand by skeletal muscles and other vital organs for energy substrates. Exercise also affects bone and mineral metabolism, particularly calcium and phosphate, both of which are essential for muscle contraction, neuromuscular signaling, biosynthesis of adenosine triphosphate (ATP), and other energy substrates. Parathyroid hormone (PTH) is involved in the regulation of calcium and phosphate homeostasis. Understanding the effects of exercise on PTH secretion is fundamental for appreciating how the body adapts to exercise. Altered PTH metabolism underlies hyperparathyroidism and hypoparathyroidism, the complications of which affect the organs involved in calcium and phosphorous metabolism (bone and kidney) and other body systems as well. Exercise affects PTH expression and secretion by altering the circulating levels of calcium and phosphate. In turn, PTH responds directly to exercise and exercise-induced myokines. Here, we review the main concepts of the regulation of PTH expression and secretion under physiological conditions, in acute and chronic exercise, and in relation to PTH-related disorders.

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“…The differential regulation of circulating PTH in cold-acclimatized individuals subjected to ice-water swimming and to non-shivering cold exposure could stem from the intensity of the cold stimulus, from the exercise component of ice-water swimming 22 , from the post-swimming shivering thermogenesis and from the difference in the body area exposed to cold (full-body cold water immersion vs. cooling pads). Meanwhile, the difference in cold-induced PTH regulation between cold acclimatized and non-acclimatized individuals is most likely related to the adaptive response to repeated cold water immersion, although we cannot rule out the effect of β 3 AR agonist and the fact that the shivering threshold in cold acclimatized individuals lies at much lower core body temperature 21 .…”

Section: Discussionmentioning

confidence: 99%

Cold exposure distinctively modulates parathyroid and thyroid hormones in cold-acclimatized and non-acclimatized humans

Kovaničová

Kurdiová

Baláž

et al. 2020

Preprint

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AbstractContextCold-induced activation of thermogenesis modulates energy metabolism, but the role of humoral mediators is not completely understood.ObjectiveTo investigate the role of parathyroid and thyroid hormones in acute and adaptive response to cold in humans.DesignCross-sectional study examining acute response to ice-water swimming and to experimental non-shivering thermogenesis (NST) induction in individuals acclimatized and non-acclimatized to cold. Seasonal variation in energy metabolism of ice-water swimmers and associations between circulating PTH and molecular components of thermogenic program in brown adipose tissue (BAT) of neck-surgery patients were evaluated.SettingClinical Research Center.Patients, ParticipantsIce-water swimmers (winter swim n=15, NST-induction n=6), non-acclimatized volunteers (NST-induction, n=11, elective neck surgery n = 36).Main Outcomes and ResultsIn ice-water swimmers, PTH and TSH increased in response to 15min winter swim, while activation of NST failed to regulate PTH and lowered TSH. In non-acclimatized men, NST-induction decreased PTH and TSH. Positive correlation between systemic levels of PTH and whole-body metabolic preference for lipids as well as BAT 18F-FDG uptake was found across the two populations. Moreover, NST-cooling protocol-induced changes in metabolic preference for lipids correlated positively with changes in PTH. Finally, variability in circulating PTH correlated positively with UCP1/UCP1, PPARGC1A and DIO2 in BAT from neck surgery patients.ConclusionsRegulation of PTH and thyroid hormones during cold exposure in humans depends on the cold acclimatization level and/or cold stimulus intensity. Role of PTH in NST is substantiated by its positive relationships with whole-body metabolic preference for lipids, BAT volume and UCP1 content.

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Parathyroid Hormone Secretion Is Controlled by Both Ionized Calcium and Phosphate During Exercise and Recovery in Men

Abstract: PTH secretion during exercise and recovery is controlled by a combination of changes in Ca(2+) and PO4 in men.

Cited by 36 publications

References 41 publications

Maintenance of Serum Ionized Calcium During Exercise Attenuates Parathyroid Hormone and Bone Resorption Responses

Maintenance of Serum Ionized Calcium During Exercise Attenuates Parathyroid Hormone and Bone Resorption Responses

Physical Activity-Dependent Regulation of Parathyroid Hormone and Calcium-Phosphorous Metabolism

Cold exposure distinctively modulates parathyroid and thyroid hormones in cold-acclimatized and non-acclimatized humans

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