Parathyroid gland function after radioiodine (131I) therapy for toxic and non-toxic goitre

Szumowski, Piotr; Abdelrazek, Saeid; Mojsak, Małgorzata; Rogowski, F; Kociura-Sawicka, Agnieszka; Myśliwiec, Janusz

doi:10.5603/ep.2013.0015

Cited by 9 publications

(22 citation statements)

References 12 publications

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“…Szumowski et al. reported that RAI for hyperthyroidism caused transient hyperparathyroidism ( 5 ). They speculated that post-radiation inflammation of the parathyroid gland may cause an excessive release of PTH in the parathyroid cells.…”

Section: Discussionmentioning

confidence: 99%

“…They speculated that post-radiation inflammation of the parathyroid gland may cause an excessive release of PTH in the parathyroid cells. They also found that when the thyroid-absorbed dose was higher, the impact on parathyroid gland function was more significant ( 5 ). It has been reported that the RAI dose rates for hyperthyroid patients were higher than those for thyroid cancer patients ( 12 ).…”

Section: Discussionmentioning

confidence: 99%

“…Szumowski et al. ( 5 ) observed parathyroid gland function changes after RAI treatment for benign thyroid disease. Their results indicated that PTH levels would be elevated for approximately ten months after RAI treatment.…”

Section: Introductionmentioning

confidence: 99%

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Parathyroid Changes After RAI in Patients With Differentiated Thyroid Carcinoma

et al. 2021

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ObjectiveThe purpose of this study was to investigate parathyroid hormone (PTH), serum calcium, phosphorus, and 25-hydroxyvitamin D (25-OH-VD) changes before and after radioactive iodine (RAI) in differentiated thyroid carcinoma (DTC) patients at different time points.MethodsA total of 259 DTC patients who received RAI were prospectively enrolled. We evaluated PTH, serum calcium, phosphorus, and 25-OH-VD levels at baseline pre-RAI, five days, six weeks, and six months post-RAI, respectively. We analyzed the risk factors of hypocalcemia at five days post-RAI.ResultsThe mean PTH, serum calcium and phosphorus values decreased five days post-RAI compared with pre-RAI (PTH 4.18 ± 1.23 pmol/L vs. 3.95 ± 1.41 pmol/L; calcium 2.27 ± 0.09 mmol/L vs. 2.20 ± 0.11 mmol/L; phosphorus 1.25 ± 0.17 vs. 0.98 ± 0.20 mmol/L, P < 0.05), and the differences were statistically significant. The mean 25-OH-VD levels did not significantly decrease at five days post-RAI. 21.2% (55/259) of patients had hypocalcemia at five days post-RAI, and all of them were given oral calcium supplements. At six weeks post-RAI, all of the above parameters were higher than those at five days post-RAI. Multivariate regression analysis showed that baseline pre-RAI serum calcium < 2.27 mmol/L, PTH < 4.18 pmol/L and negative 99mTcO4- thyroid imaging were risk factors for hypocalcemia at five days post-RAI.ConclusionFor DTC patients with normal PTH and serum calcium levels at pre-RAI, their PTH, serum calcium, and phosphorus levels decreased at five days post-RAI. About one-fifth of patients could have hypocalcemia at five days post-RAI. Lower baseline pre-RAI serum calcium and PTH levels and negative 99mTcO4- thyroid imaging were risk factors for hypocalcemia five days post-RAI.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Parathyroid Changes After RAI in Patients With Differentiated Thyroid Carcinoma

et al. 2021

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“…Mortensen LS's study investigated parathyroid function over the long term (8-12 years) after RAI for benign thyroid diseases, and no significant changes in calcium or PTH were found (31). Szumowski P's study (32) found a transient decline in PTH without a significant change in calcium, phosphates and symptoms following high-dose (100 mCi or 150 mCi) RAI therapy for toxic and nontoxic goiters. Similar results were reported in Guven A's studies focusing on thyroid cancer (33).…”

Section: Discussionmentioning

confidence: 99%

Idiopathic Hypoparathyroidism With Papillary Thyroid Carcinoma in a Young Male: A Rare Case Report

Chen

Wei

et al. 2020

Front. Endocrinol.

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BackgroundIdiopathic hypoparathyroidism (IHP) is a rare disorder that is diagnosed by excluding other possible etiologies. Thyroid surgery causes approximately 14–60% of all cases of hypoparathyroidism; of these, surgery for papillary thyroid carcinoma (PTC) is the most common reason. Here, we report an extremely rare case of IHP combined with PTC.Case presentationA 22-year-old man presented with a history of uncontrollable extremity and facial numbness, spasm and twitch lasting for nine years. He had been misdiagnosed with epilepsy and gained no relief from antiepileptic therapy. The laboratory evaluation revealed reduced parathyroid hormone and serum calcium and elevated inorganic phosphorus. After considering IHP, ultrasound detected a solid hypoechoic and irregularly shaped nodule 13×8×9 mm in size in the upper pole of the right thyroid gland, and fine-needle aspiration biopsy indicated PTC. Then, the patient underwent surgical treatment and radioactive iodine ablation. The long-term treatment strategy consisted of oral levothyroxine for thyroid-stimulating hormone inhibition and oral calcium and vitamin D supplements for hypocalcemia control.ConclusionWe report a rare case of IHP combined with PTC in a 22-year-old male. Some experiences and lessons from our treatment procedure merit discussion, and we hope that our report can serve as a reference for the diagnosis and treatment of similar patients in the future.

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“…On the contrary, the younger the age of radiation exposure, the more likely it is to develop thyroid cancer earlier [72]. In the study by Piotr Szumowski [73], they treated benign thyroid diseases with absorbed dose of 140Gy, 180Gy and 240Gy according to different disease category, and found that PTH increased most significantly in patients with absorbed dose 240Gy within 6 months after RAI treatment. However, Hamilton TE [74] unmasked that the higher dose of exposure radiation may not increase the risk of hyperparathyroidism.…”

Section: Effect Of Rai Treatment On Parathyroid Function For Benign Thyroid Diseasementioning

confidence: 99%

Effect of Parathyroid Function After Thyroidectomy and Radioactive-Iodine Therapy for Thyroid Disease

Xiao¹,

Zhang²,

Li³

2019

BJSTR

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Objective: Thyroidectomy and radioactive-iodine (RAI) treatment are two important methods for benign and malignant thyroid diseases. Thyroidectomy and RAI treatment may influence parathyroid gland function. This paper systematically reviewed the literatures on the effect of thyroidectomy and RAI on parathyroid gland function in patients with benign and maligant thyroid disease. Subjective and Methods:We searched PubMed for English literautres by using terms of "thyroidectomy" or "radioactive iodine" and "hyperthyroidism" or "Graves' disease" or "toxic multinodular goiter" or "toxic adenoma" or "differentiated thyroid carcinoma" and "parathyroid gland" or "calcium" or "parathyroid hormone" to review the effect of thyroidectomy and RAI on parathyroid gland function.Result: Thyroidectomy may lead to hypocalcaemia and hypoparathyroidism both for benign thyroid disease and DTC. For benign thyroid disease, RAI treatment may cause increasing PTH in the short term and may induce parathyroid adenoma or hyperplasia in the long term. For DTC patients, parathyroid gland function may transiently decline after RAI treatment. Conclusion:Thyroidectomy and RAI treatment may influence the parathyroid function in both benign and DTC patients. Thus, it is important to monitor PTH and blood calcium regularly in order to detect early abnormal parathyroid function for those patients.

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Parathyroid gland function after radioiodine (131I) therapy for toxic and non-toxic goitre

Abstract: Introduction: The therapeutic effect of radioactive iodine (

Cited by 9 publications

References 12 publications

Parathyroid Changes After RAI in Patients With Differentiated Thyroid Carcinoma

Parathyroid Changes After RAI in Patients With Differentiated Thyroid Carcinoma

Idiopathic Hypoparathyroidism With Papillary Thyroid Carcinoma in a Young Male: A Rare Case Report

Effect of Parathyroid Function After Thyroidectomy and Radioactive-Iodine Therapy for Thyroid Disease

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